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Current Drug Therapy


ISSN (Print): 1574-8855
ISSN (Online): 2212-3903

Research Article

The Effect of Treatment and Bone Metabolic Factors on Fracture Incidence in Patients with Thalassemia-Induced Osteoporosis: An Observational Study

Author(s): Athanasios N. Tsartsalis*, George I. Lambrou, Eugenia Vlachou, Athanasia Samartzi, George P. Chrousos, Christina Kanaka-Gantenbein and Antonis Kattamis

Volume 15, Issue 4, 2020

Page: [381 - 388] Pages: 8

DOI: 10.2174/1574885515666200106110602


Background: Thalassemia Major (TM) is a hereditary disease caused by defective globin synthesis. Because of the significant increase in life expectancy, these patients suffer from various health conditions, including endocrinopathies and low bone mineral density.

Aim: The aim of the present study was to evaluate the fracture incidence regarding the markers of bone metabolism, bone mineral density and treatment of osteoporosis as well as the treatment of comorbidities.

Methods: Sixty-four patients with TM (32 men and 32 women) participated in a cross-sectional study design. The patients were recruited from “Aghia Sofia” Children’s Hospital and evaluated using Dual-energy X-ray Absorptiometry (DXA) of the lumbar spine and femoral neck and with markers of bone remodeling including Receptor Activator of Nuclear factor Kappa-Β Ligand (RANKL), Osteoprotegerin (OPG), C-Terminal Telopeptide (CTX), and sclerostin.

Results: The statistical analysis of markers of bone metabolism in relation to fractures revealed no statistical significance. However, statistical analysis of bone mineral density and markers of bone metabolism in relation to fractures was also not significant.

Conclusions: In TM patients, fractures are not related to bone mineral density. Maybe some other conditions are the cause, haemosidirosis, drugs, comorbid conditions.

Keywords: Osteoporosis, thalassemia major, fracture, sclerostin, RANKL, OPG.

Graphical Abstract
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