Abstract
The paper deals with the most important items regarding the improvement of quality of experimental procedures when testing drug effects on behaviour and development of commonly-used rodent species. Current-used test procedures for immature and adult rodents exposed early developmentally are briefly described and recent advances and difficulties in their hands-on interpretation are highlighted. Comparability of measures in human and animals for drug-effect assess-ment is also shortly discussed. It is then stressed that studies on rodents carried out in seminaturalistic and naturalistic settings may offer a highly profitable direction for future research in behavioural teratology and toxicology. A final paragraph is dedicated to the bioethical aspects arisen from the use of large number of rodents subjects in behavioural testing.
Keywords: Behaviovioural Treratology, rodents, fostering procedure, un fostering, in fostering, cross fostering, standard fostering, Crouching behaviour, straight jackets, statistical analysis, ANOVAs, pup reactivity, developmental studies, Drug challenge, psychoactive drugs, ultrasonic vocalisations, neonates, mental behaviour, locomotor, adult behaviour, rearing, avoidance task, sniffing, neophobia level, hot plate testing, naturalsitic
Current Pharmaceutical Design
Title: Important Hints in Behavioural Teratology of Rodents
Volume: 6 Issue: 1
Author(s): Enrico Alleva and Alberto Sorace
Affiliation:
Keywords: Behaviovioural Treratology, rodents, fostering procedure, un fostering, in fostering, cross fostering, standard fostering, Crouching behaviour, straight jackets, statistical analysis, ANOVAs, pup reactivity, developmental studies, Drug challenge, psychoactive drugs, ultrasonic vocalisations, neonates, mental behaviour, locomotor, adult behaviour, rearing, avoidance task, sniffing, neophobia level, hot plate testing, naturalsitic
Abstract: The paper deals with the most important items regarding the improvement of quality of experimental procedures when testing drug effects on behaviour and development of commonly-used rodent species. Current-used test procedures for immature and adult rodents exposed early developmentally are briefly described and recent advances and difficulties in their hands-on interpretation are highlighted. Comparability of measures in human and animals for drug-effect assess-ment is also shortly discussed. It is then stressed that studies on rodents carried out in seminaturalistic and naturalistic settings may offer a highly profitable direction for future research in behavioural teratology and toxicology. A final paragraph is dedicated to the bioethical aspects arisen from the use of large number of rodents subjects in behavioural testing.
Export Options
About this article
Cite this article as:
Alleva Enrico and Sorace Alberto, Important Hints in Behavioural Teratology of Rodents, Current Pharmaceutical Design 2000; 6 (1) . https://dx.doi.org/10.2174/1381612003401389
DOI https://dx.doi.org/10.2174/1381612003401389 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Congenital Duodenal Obstruction: The Impact of Downs Syndrome in Neonatal Morbidity. A Two-Center Survey
Current Pediatric Reviews Preterm Labour: An Overview of Current and Emerging Therapeutics
Current Medicinal Chemistry Ovulation, Implantation and Placentation in Females with Obesity and Metabolic Disorders: Life in the Balance
Endocrine, Metabolic & Immune Disorders - Drug Targets A Scientometrics Analysis and Visualization of Depressive Disorder
Current Neuropharmacology Polypharmacy in Chronic Neurological Diseases: Multiple Sclerosis, Dementia and Parkinson’s Disease
Current Pharmaceutical Design Fospropofol, A New Sedative Anesthetic, and Its Utility in the Perioperative Period
Current Pharmaceutical Design Intrauterine Intervention for the Treatment of Fetal Growth Restriction
Current Pediatric Reviews Renoprotection by Direct Renin Inhibition: A Review Article and Meta-Analysis
Current Vascular Pharmacology Renin-Angiotensin-Aldosterone System: A Current Drug Target for the Management of Neuropathic Pain
Current Drug Targets Impact of COVID-19 Infection on Maternal and Neonatal Outcomes: A Review of 11078 Pregnancies Reported in the Literature
Current Women`s Health Reviews Hutchinson-Gilford Progeria Syndrome (Hgps) and Application of Gene Therapy Based Crispr/Cas Technology as A Promising Innovative Treatment Approach
Recent Patents on Biotechnology Interaction Between Platelets and Cytokines - A Possible Role in the Pathogenesis of Preeclampsia
Vascular Disease Prevention (Discontinued) Lipoprotein (a) and Cardiovascular Risk: The Show Must go on
Current Medicinal Chemistry Drug Repurposing: An Emerging Tool for Drug Reuse, Recycling and Discovery
Current Drug Research Reviews Pharmacogenetics and Anaesthesiology
Current Pharmacogenomics Atheroma Burden and Morphology in Women
Current Pharmaceutical Design Relaxin, Insulin and Diabetes: An Intriguing Connection
Current Diabetes Reviews Chemotherapy for Prostate Cancer
Current Pharmaceutical Design The Heat Stress Response and Diabetes: More Room for Mitochondrial Implication
Current Pharmaceutical Design Beta-Blockers: Current State of Knowledge and Perspectives
Mini-Reviews in Medicinal Chemistry