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Current Drug Discovery Technologies


ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

Review Article

A Review of Pharmacological Properties and Toxicological Effects of Adiantum capillus-veneris L.

Author(s): Ali Kashkooe, Frough Afsari Sardari, Mahkameh Moradi Mehrabadi and Mohammad M. Zarshenas*

Volume 18, Issue 2, 2021

Published on: 16 March, 2020

Article ID: e291221180224 Pages: 8

DOI: 10.2174/1570163817666200316111445

Price: $65


Background: Adiantum capillus-veneris L. (Family: Pteridaceae) is a well-known safe medicinal herb used in traditional and modern medicine due to its beneficial pharmacological properties. The current study aimed to compile a review on phytochemicals, pharmacological properties and toxicological effects of this plant.

Methods: An incisive search was conducted through electronic scientific databases including PubMed, Scopus, ScienceDirect, and Cochrane Library using keyword ‘Adiantum capillusveneris’. All related in vivo, in vitro, human (English papers), were selected from the beginning up to 1st January 2019. All letters, conference papers, papers dealing with genetics, agriculture, and pure phytochemistry of the herb were excluded.

Results: A. capillus veneris revealed various pharmacological activities including the effects on the remodeling of lung alveolar epithelial cells in a hypoxic environment, anti-toxicity properties in liver and testes, anti-hyperglycemic, and wound healing effects in diabetic or non-diabetic patients, protection against damage to fibroblasts via free radicals, activity against testosteroneinduced alopecia, anticonvulsant, depressant, analgesic and anti-nociceptive activities, as well as effects on urinary output, anti-inflammatory, anti-microbial, antilithiatic, hypothyroidism regulatory, anti-cancer, antidiarrheal and antispasmodic, anti-asthmatic and anti-histaminic, and enzyme inhibition (in Alzheimer’s, diabetes and skin disorders) activities.

Conclusion: This plant can be used as a natural potent and safe agent to alleviate numerous medical symptoms and diseases due to its useful pharmacological properties. Thus, further researches are needed in order to compile the clinical effects of this plant via human studies.

Keywords: Adiantum capillus-veneris, maidenhair fern, herbal medicine, medicinal plants, pharmacology, phytochemicals.

Graphical Abstract
Al-Qura’n S. Ethnopharmacological survey of wild medicinal plants in Showbak, Jordan. J Ethnopharmacol 2009; 123(1): 45-50.
[] [PMID: 19429338]
Singh S, Khatoon S, Singh H, Behera S, Khare P, Rawat A. A report on pharmacognostical evaluation of four Adiantum species, Pteridophyta, for their authentication and quality control. Rev Bras Farmacogn 2013; 23: 207-16.
Khodaie L, Esnaashari S, Bamdad Moghaddam S. Essential oil of arial parts of adiantum capillus-veneris: Chemical composition and antioxidant activity. J Nat Pharm Prod 2015; 10: 3-7.
Dehdari S, Hajimehdipoor H. Medicinal properties of Adiantum capillus-veneris linn. in traditional medicine and modern phytotherapy: A review article. Iran J Public Health 2018; 47(2): 188-97.
[PMID: 29445628]
Jankowski C, Aumelas A, Thuery P, et al. X-ray,^ 1H/^ 1^ 3C 2D and 3D NMR studies of the structures of davallene and adipedatol, two triterpenes isolated from American Adiantum capillus-veneris. Pol J Chem 2004; 78: 389-408.
Nakane T, Maeda Y, Ebihara H, et al. Fern constituents: triterpenoids from Adiantum capillus-veneris. Chem Pharm Bull (Tokyo) 2002; 50(9): 1273-5.
[] [PMID: 12237552]
Nakane T, Arai Y, Masuda K, Ishizaki Y, Ageta H, Shiojima K. Fern constituents: Six new triterpenoid alcohols from Adiantum capillus-veneris. Chem Pharm Bull (Tokyo) 1999; 47: 543-7.
Berti G, Bottari F, Marsili A. Structure and stereochemistry of a triterpenoid expoxide from Adiantum capillus-Veneris. Tetrahedron 1969; 25(15): 2939-47.
[] [PMID: 5802374]
Zeb A, Ullah F. Reversed phase HPLC-DAD profiling of carotenoids, chlorophylls and phenolic compounds in Adiantum capillus-veneris leaves. Front Chem 2017; 5: 29.
[] [PMID: 28497036]
Rastogi S, Pandey MM, Rawat AKS. Ethnopharmacological uses, phytochemistry and pharmacology of genus Adiantum: A comprehensive review. J Ethnopharmacol 2018; 215: 101-19.
[] [PMID: 29288826]
Ishaq MS, Hussain MM, Afridi MS, et al. In vitro phytochemical, antibacterial, and antifungal activities of leaf, stem, and root extracts of Adiantum capillus veneris. Sci World J 2014.2014269793
[] [PMID: 24592156]
Kumar S, Samydurai P, Ramakrishnan R, Nagarajan N. Gas chromatography and mass spectrometry analysis of bioactive constituents of Adiantum capillus-veneris L. Int J Pharm Pharm Sci 2014; 6: 60-3.
Imperato F. Sulphate esters of hydroxycinnamic acid-sugar derivatives from Adiantum capillus-veneris. Phytochemistry 1982; 21: 2717-8.
Yadegari M, Riahy S, Mirdar S, Hamidian G. Interactive effects of reducing exercise intensity and Adiantum capillus veneris extract on remodeling and modulation of pulmonary apoptotic indices in the rats exposed to the hypoxia. Majallah-i Ilmi-i Danishgah-i Ulum-i Pizishki-i Kurdistan 2018; 23: 81-91.
Yadegari M, Riahy S, Mirdar S, Hamidian G. Effect of the adiantum capillus veneris extract on Bax and Bcl2 apoptotic markers of lung modulation in trained rats and exposed to hypoxic stress. Faslnamah-i Giyahan-i Daruyi 2018; 4: 162-71.
Al-Hallaq EK, Litescu SC, Kasabri V, Abdul-Razzak KK, Afifi F. Hypocholesterolemic effects of Adiantum capillus veneris L. aqueous extract in high cholesterol diet-fed rats and HPLC-MS determination of its polyphenolics. Rev Roum Chim 2015; 60: 357-65.
Kanwal Q, Qadir A. Amina, Asmatullah, Iqbal HH, Munir B. Healing potential of Adiantum capillus-veneris L. plant extract on bisphenol A-induced hepatic toxicity in male albino rats. Environ Sci Pollut Res Int 2018; 25(12): 11884-92.
[] [PMID: 29446025]
Jiang M-Z, Yan H, Wen Y, Li X-M. In vitro and in vivo studies of antioxidant activities of flavonoids from Adiantum capillus-veneris L. Afr J Pharm Pharmacol 2011; 5: 2079-85.
Yousaf B, Amina , Liu G, et al. Bisphenol A exposure and healing effects of Adiantum capillus-veneris L. plant extract (APE) in bisphenol A-induced reproductive toxicity in albino rats. Environ Sci Pollut Res Int 2016; 23(12): 11645-57.
[] [PMID: 26936479]
Ranjan V, Vats M, Gupta N, Sardana S. Antidiabetic potential of whole plant of Adiantum capillus veneris linn. in streptozotocin induced diabetic rats. Int J Pharm Chem Res 2014; 6: 341-7.
Kasabri V, Al-Hallaq EK, Bustanji YK, Abdul-Razzak KK, Abaza IF, Afifi FU. Antiobesity and antihyperglycaemic effects of Adiantum capillus-veneris extracts: in vitro and in vivo evaluations. Pharm Biol 2017; 55(1): 164-72.
[] [PMID: 27663206]
Negahdari S, Galehdari H, Kesmati M, Rezaie A, Shariati G, Shapouri MS. Analysis of VEGF AND TGFB1 proteins in normal and streptozotocin-induced diabetic rats, during treatment of formulations of Aloe Vera, Henna, Adiantum capillus-veneris, and Myrrha. Wound Medicine 2017; 16: 22-8.
Galehdari H, Negahdari S, Kesmati M, Rezaie A, Shariati G. Effect of the herbal mixture composed of Aloe Vera, Henna, Adiantum capillus-veneris, and Myrrha on wound healing in streptozotocin-induced diabetic rats. BMC Complement Altern Med 2016; 16(1): 386.
[] [PMID: 27716154]
Soliman A, Teoh SL, Ghafar N, Das S. Molecular concept of diabetic wound healing: effective role of herbal remedies. Mini Rev Med Chem 2018.
[PMID: 30360709]
Negahdari S, Galehdari H, Kesmati M, Rezaie A, Shariati G. Wound healing activity of extracts and formulations of Aloe vera, Henna, Adiantum capillus-veneris, and myrrh on mouse dermal fibroblast cells. Int J Prev Med 2017; 8: 18.
[] [PMID: 28382194]
Nilforoushzadeh MA, Javanmard SH, Ghanadian M, et al. The effects of adiantum capillus-veneris on wound healing: An experimental in vitro evaluation. Int J Prev Med 2014; 5(10): 1261-8.
[PMID: 25400884]
Noubarani M, Rostamkhani H, Erfan M, et al. Effect of adiantum capillus veneris linn on an animal model of testosterone-induced hair loss. Iran J Pharm Res 2014; 13(Suppl.): 113-8.
[PMID: 24711836]
Jain S, Singh T, Pande M, Nema N. Neuropharmacological screening of fronds of Adiantum capillus veneris linn. Pharm Lett 2014; 6: 167-75.
Haider S, Nazreen S, Alam MM, Gupta A, Hamid H, Alam MS. Anti-inflammatory and anti-nociceptive activities of ethanolic extract and its various fractions from Adiantum capillus veneris Linn. J Ethnopharmacol 2011; 138(3): 741-7.
[] [PMID: 22020277]
Haider S, Kharbanda C, Alam MS, et al. Anti-inflammatory and anti-nociceptive activities of two new triterpenoids from Adiantum capillus-veneris Linn. Nat Prod Res 2013; 27(24): 2304-10.
[] [PMID: 23972143]
Yuan Q, Ruan J, Cai Y. Effect of water extracts of Adiantum capillus-veneris L. on urinary tract infections. Chung Kuo Yao Hsueh Tsa Chih 2010; 45: 1389-92.
Yuan Q, Zhang X, Liu Z, et al. Ethanol extract of Adiantum capillus-veneris L. suppresses the production of inflammatory mediators by inhibiting NF-κB activation. J Ethnopharmacol 2013; 147(3): 603-11.
[] [PMID: 23542147]
Ibraheim ZZ, Ahmed AS, Gouda YG. Phytochemical and biological studies of Adiantum capillus-veneris L. Saudi Pharm J 2011; 19(2): 65-74.
[] [PMID: 23960744]
Mahmoud MJ, Jawad A-LM, Hussain AM, Al-Omari M, Al-Naib A. In vitro antimicrobial activity of Salsola rosmarinus and Adiantum capillus-veneris. Int J Crude Drug Res 1989; 27: 14-6.
Shirazi M, Amin G, Akhondi Lavasani B, Eshraghi S. Study of antibacterial properties of Adiantum capillus-veneris extract on eight species of gram positive and negative bacteria. Faslnamah-i Giyahan-i Daruyi 2011; 4: 124-32.
Singh M, Singh N, Khare PB, Rawat AK. Antimicrobial activity of some important Adiantum species used traditionally in indigenous systems of medicine. J Ethnopharmacol 2008; 115(2): 327-9.
[] [PMID: 17997240]
Besharat M, Rahimian M, Ghaemi E, Besharat S. Effect of ethanolic extract of Adiantum capillus-veneris in comparison with Gentamicine on 3 pathogenic bacteria in vitro. Pharm Sci 2009; 15: 49-52.
Zhang X, Chen H-L, Hong L, et al. Three new hopane-type triterpenoids from the aerial part of Adiantum capillus-veneris and their antimicrobial activities. Fitoterapia 2019; 133: 146-9.
[] [PMID: 30654129]
Ahmed A, Wadud A, Jahan N, Bilal A, Hajera S. Efficacy of Adiantum capillus veneris Linn in chemically induced urolithiasis in rats. J Ethnopharmacol 2013; 146(1): 411-6.
[] [PMID: 23333749]
Ahmed A, Jahan N, Wadud A, Bilal A, Hajera S. In vitro effect of hydro alcoholic extract of Adiantum capillus-veneris Linn on calcium oxalate crystallization. Int J Green Pharmacy 2013; p. 7.
Vijayalakshmi A, Kumar YK. Evaluation of goitrogenic and antithyroidal effect of the fern Adiantum capillus-veneris. Rev Bras Farmacogn 2013; 23: 802-10.
Rautray S, Panikar S, Amutha T, Rajananthini AU. Anticancer activity of Adiantum capillus veneris and Pteris quadriureta L. in human breast cancer cell lines. Mol Biol Rep 2018; 45(6): 1897-911.
[] [PMID: 30194562]
Janbaz KH, Hassan W, Mehmood H, Gilani AH. Antidiarrheal and antispasmodic activities of Adiantum capillus-veneris are predominantly mediated through ATP-dependent K+ channels activation. Bangladesh J Pharmacol 2015; 10: 222.
Swaroop Kumar K, Anbu J, Anjana A, Sumithra M, Sathish R. Influence of ethanolic leaf extract of Sargassum wightii and Adiantum capillus on histamine induced asthma in animal model. Int J Pharm Pharm Sci 2012; 4: 121-3.
Abdulqadir A, Cakmak YS, Zengin G. Phenolic compounds, antioxidant properties and enzyme inhibition ability of adiantum capillus veneris L. linked to Alzheimer’s Disease, Diabetes Mellitus and Skin Disorders. Curr Org Chem 2018; 22: 1697-703.

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