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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Molecular Targets in Cancer Drug Discovery: Cell-Based Profiling

Author(s): John N. Weinstein and John K. Buolamwini

Volume 6, Issue 4, 2000

Page: [473 - 483] Pages: 11

DOI: 10.2174/1381612003400894

Price: $65

Abstract

The phrase molecular target-based drug discovery usually implies an in vitro biochemical assay or battery of assays. One portion of the U.S. National Cancer Institutes drug discovery program, to the contrary, examines molecular targets for cancer therapy in a cell-based format. That approach has a number of sig-nificant limitations, but it has produced databases of significant utility on the activities and structures of tested compounds, as well as on molecular characteristics of the cell types used for testing.

Keywords: cel based profiling, molecular target, cacer genome, NCI cell screen, anticancer agents, protein expression


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