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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Selective Estrogen Receptor Modulators (SERMs): Effects on Multiple Organ Systems

Author(s): D. Agnusdei and N. Iori

Volume 7, Issue 5, 2000

Page: [577 - 584] Pages: 8

DOI: 10.2174/0929867003375056

Price: $65

Abstract

SERMs represent a structurally diverse group of compounds which interact with the estrogen receptor but which elicit agonist or antagonist activity depending on the organ system and physiological context. Evaluation of the actions of these compounds has led researchers to a fuller understanding not only of the antiestrogens but also of steroid signaling in general. Based on their evolving clinical profiles, SERMs have the potential to address long-term health maintenance needs of women in their non-reproductive years.

Keywords: selective estrogen receptor modulators SERMs, antiestrogens, tamoxifen, raloxifene


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