Abstract
The recent success of the human genome project and the continued accomplishment in obtaining DNA sequences for a vast array of organisms is providing an unprecedented wealth of information. Nevertheless, an abundance of the proteome contains hypothetical proteins or proteins of unknown function, where high throughput approaches for genome- wide functional annotation (functional genomics) has evolved as the necessary next step. Nuclear magnetic resonance spectroscopy is playing an important role in functional genomics by providing information on the structure of protein and protein-ligand complexes, from metabolite fingerprinting and profiling, from the analysis of the metabolome, and from ligand affinity screens to identify chemical probes.
Keywords: NMR, functional genomics, NMR high throughput screens, protein-ligand binding, protein-ligand co-structures, structural biology, structural genomics, NMR metabolomics, chemical proteomics, protein structure initiative
Combinatorial Chemistry & High Throughput Screening
Title: Functional Genomics and NMR Spectroscopy
Volume: 10 Issue: 8
Author(s): Robert Powers
Affiliation:
Keywords: NMR, functional genomics, NMR high throughput screens, protein-ligand binding, protein-ligand co-structures, structural biology, structural genomics, NMR metabolomics, chemical proteomics, protein structure initiative
Abstract: The recent success of the human genome project and the continued accomplishment in obtaining DNA sequences for a vast array of organisms is providing an unprecedented wealth of information. Nevertheless, an abundance of the proteome contains hypothetical proteins or proteins of unknown function, where high throughput approaches for genome- wide functional annotation (functional genomics) has evolved as the necessary next step. Nuclear magnetic resonance spectroscopy is playing an important role in functional genomics by providing information on the structure of protein and protein-ligand complexes, from metabolite fingerprinting and profiling, from the analysis of the metabolome, and from ligand affinity screens to identify chemical probes.
Export Options
About this article
Cite this article as:
Powers Robert, Functional Genomics and NMR Spectroscopy, Combinatorial Chemistry & High Throughput Screening 2007; 10 (8) . https://dx.doi.org/10.2174/138620707782507331
DOI https://dx.doi.org/10.2174/138620707782507331 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Biological Applications of ZnO Nanoparticles
Current Molecular Imaging (Discontinued) A Closer Look to Polyesters: Properties, Synthesis, Characterization, and Particle Drug Delivery Applications
Nanoscience & Nanotechnology-Asia How to Fluorescently Label the Potassium Channel: A Case in hERG
Current Medicinal Chemistry The Effect of Polyphenol Consumption on Blood Pressure
Mini-Reviews in Medicinal Chemistry The Ligand Binding Region of the Sigma-1 Receptor: Studies Utilizing Photoaffinity Probes, Sphingosine and N-Alkylamines
Current Pharmaceutical Design Animal Galectins and Plant Lectins as Tools for Studies in Neurosciences
Current Neuropharmacology 4-Oxa-1-azabicyclo[3.2.0]heptan-7-one Derivatives as Anti-Tumor Agents
Current Medicinal Chemistry - Anti-Cancer Agents The Multifaceted Roles of Molecular Dynamics Simulations in Drug Discovery
Current Pharmaceutical Design Activity Based Probes for Proteases: Applications to Biomarker Discovery,Molecular Imaging and Drug Screening
Current Pharmaceutical Design Application of Microdialysis in Clinical Pharmacology
Current Clinical Pharmacology Towards Understanding the Structure-Function Relationship of Human Amyloid Disease
Current Drug Targets The Use of Conformational Restriction in Medicinal Chemistry
Current Topics in Medicinal Chemistry Immune Modulation of Asian Folk Herbal Medicines and Related Chemical Components for Cancer Management
Current Medicinal Chemistry Toxicity and Relative Biological Effectiveness of Alpha Emitting Radioimmunoconjugates
Current Radiopharmaceuticals Stereochemistry as a Determinant of the Anti-Leukemic Potency of Halopyridyl and Thiazolyl Thiourea Compounds
Letters in Drug Design & Discovery Oxycodone/Naloxone in the Management of Patients with Pain and Opioid–Induced Bowel Dysfunction
Current Drug Targets Aberrant DNA Methylation and Prostate Cancer
Current Genomics Increased Production of Recombinant O-Phospho-L-Serine Sulfhydrylase from the Hyperthermophilic Archaeon Aeropyrum pernix K1 Using Escherichia coli
Current Biotechnology An Efficient Protocol for the Synthesis of new Camphor Pyrimidine and Camphor Thiazole Derivatives using Conventional and Microwave Irradiation Techniques and <i>In vitro</i> Evaluation as Potential Antimicrobial Agents
Current Organic Synthesis Innovative Stride to Zero Hunger Beyond 2015 in Nigeria
Recent Patents on Food, Nutrition & Agriculture