Abstract
Mesenchymal Stem Cells (MSCs) possess unique properties that make them potential carriers for cancer therapy. MSCs have been documented to have low immunogenicity, positive safety in clinical trials, and the ability to selectively perform homing to inflammation and tumor sites. This review aims to introduce tumor tropism mechanism and effects of MSCs on tumor cells, and give an overview of MSCs in delivering gene therapeutic agents, oncolytic viruses and chemotherapeutics, as well as the application of MSCs-derived exosomes in tumor-targeted therapy.
Keywords: Mesenchymal stem cells, tumor-targeted therapy, cell-mediated drug delivery, exosomes, nanoparticles, gene therapy.
Current Drug Delivery
Title:Mesenchymal Stem Cells Mediated Drug Delivery in Tumor-Targeted Therapy
Volume: 18 Issue: 7
Author(s): Mengying Xie, Lei Tao, Ziqi Zhang and Wei Wang*
Affiliation:
- Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198,China
Keywords: Mesenchymal stem cells, tumor-targeted therapy, cell-mediated drug delivery, exosomes, nanoparticles, gene therapy.
Abstract: Mesenchymal Stem Cells (MSCs) possess unique properties that make them potential carriers for cancer therapy. MSCs have been documented to have low immunogenicity, positive safety in clinical trials, and the ability to selectively perform homing to inflammation and tumor sites. This review aims to introduce tumor tropism mechanism and effects of MSCs on tumor cells, and give an overview of MSCs in delivering gene therapeutic agents, oncolytic viruses and chemotherapeutics, as well as the application of MSCs-derived exosomes in tumor-targeted therapy.
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Cite this article as:
Xie Mengying, Tao Lei , Zhang Ziqi and Wang Wei*, Mesenchymal Stem Cells Mediated Drug Delivery in Tumor-Targeted Therapy, Current Drug Delivery 2021; 18 (7) . https://dx.doi.org/10.2174/1567201817999200819140912
DOI https://dx.doi.org/10.2174/1567201817999200819140912 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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