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Current Pharmaceutical Biotechnology


ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Review Article

Phytochemistry, Traditional Uses and Pharmacological Properties of Enhydra fluctuans Lour: a Comprehensive Review

Author(s): Antica Barua, Muhammad S. Alam, Md. Junaid, Yeasmin Akter, Syeda S. Afrose, Tania Sharmin*, Rasheda Akter and S.M. Zahid Hosen

Volume 22, Issue 8, 2021

Published on: 22 September, 2020

Page: [1061 - 1068] Pages: 8

DOI: 10.2174/1389201021666200922161529

Price: $65


Background: Enhydra fluctuans Lour, a tropical herb, commonly known as helencha or harkuch, belongs to the family Asteraceae. It is an edible semi-aquatic herbaceous vegetable plant with serrate leaves and grows commonly in different parts of the world. Enhydra fluctuans possesses potential pharmacological role against inflammation, cancer, diarrhea, microbial infection, diabetes, etc.

Aim: This review aims to provide the most current information on the botanical characterization, distribution, traditional uses, chemical constituents, as well as the pharmacological activities of Enhydra fluctuans Lour.

Materials and Methods: The recently updated information on Enhydra fluctuans was gathered from scientific journals, books, and worldwide accepted scientific databases via a library and electronic search PubMed, Elsevier, Google Scholar, Springer, Scopus, Web of Science, Wiley online library. All of the full-text articles and abstracts related to Enhydra were screened. The most important and relevant articles were carefully chosen for study in this review.

Results: Crude extracts and isolated compounds of Enhydra fluctuans Lour have been reported to be pharmacologically active against cytoprotective, analgesic and anti-inflammatory, antimicrobial, anticancer, antidiarrheal, antihelmintic, CNS depressant, hepatoprotective, thrombolytic, antidiabetic, antioxidant, phagocytic and cytotoxic, and neuroprotective potential activities.

Discussion: Phytochemical analysis from different studies has reported Germacranolide, Sesquiterpene lactone, Flavonoid, Essential oil, Steroid, Diterpenoid, Melampolide, Sesquiterpene lactone, and Isoflavone glycoside as major compounds of Enhydra fluctuans Lour.

Conclusion: However, more research is needed to explore the mode of action of bioactive components of the plant and its therapeutic capabilities.

Keywords: Enhydra fluctuans Lour, asteraceae, botanical characterization, ethnobotanical uses, chemical constituents, pharmacological activities.

Graphical Abstract
Veeresham, C. Natural products derived from plants as a source of drugs. J. Adv. Pharm. Technol. Res., 2012, 3(4), 200-201.
[] [PMID: 23378939]
Ali, M.R.; Billah, M.M.; Hassan, M.M.; Dewan, S.M.R.; Al-Emran, M. Enhydra fluctuans Lour: A review. Asian J. Res. Chem, 2013, 6(9), 927-729.
Achika, J.I.; Arthur, D.E.; Gerald, I.; Adedayo, A. A review on the phytoconstituents and related medicinal properties of plants in the Asteraceae family. J. Appl. Chem., 2014, 7(8), 1-8.
Ghani, A. Medicinal plants of Bangladesh: chemical constituents and uses, 1st ed.; Asiatic society of Bangladesh: Dhaka, Bangladesh,; , 1998.
Sarma, U.; Borah, V.V.; Saikia, K.K.; Hazarika, N. Enhydra fluctuans: A review on its pharmacological importance as a medicinal plant and prevalence and use in Northeast India. Int. J. Pharm. Pharm. Sci., 2014, 6(2), 48-50.
Kumar, N.K.M.; Shamra, B. Leafy drugs from Tehsil Joginder Nagar, District Mandi; India Res; Pharm: Himachal Pradesh, 2014, p. 4.
Khare, C.P. Indian Medicinal Plants: An Illustrated Dictionary. Khare, C.P. ., Ed; Springer New York: New York, NY; , 2007.
Bora, Y.; Kumar, P. Floristic diversity of Assam: Study of Pabitora Wildlife Sanctuary; Daya Publishing House, 2002, pp. 183-184.
Chakraborty, R.; De, B.; Devanna, N.; Sen, S. North-East India an ethnic storehouse of unexplored medicinal plants. J. Nat. Prod. Plant. Resour., 2012, 2(1), 143-152.
Barbhuiya, A.; Sharma, G.; Arunachalam, A.; Deb, S. Diversity and conservation of medicinal plants in Barak valley. Northeast India. Indian J. Tradit. Knowl., 2009, 8, 169-175.
Das, A.K.; Dutta, B.; Sharma, G. Medicinal plants used by different tribes of Cachar district, Assam. Indian J. Tradit. Knowl., 2008, 7, 446-454.
Patil, K.S.; Majumder, P.; Wadekar, R. Effect of Enhydra fluctuans Lour. leaf extract on phagocytosis by human neutrophils. J. Nat. Rem., 2008, 8(1), 76-81.
Jaiswal, V. Culture and ethnobotany of Jaintia tribal community of Meghalaya, Northeast India-A mini review. Indian J. Tradit. Knowl., 2010, 9, 38-44.
Dolui, A.; Sharma, H.; Marein, T.B. Folk herbal remedies from Meghalaya. Indian J. Tradit. Knowl., 2004, 3, 358-364.
Khan, M.H.; Yadava, P. Antidiabetic plants used in Thoubal district of Manipur, Northeast India. Indian J. Tradit. Knowl., 2010, 9, 510-514.
Kona, S.; Rahman, A. Inventory of medicinal plants at Mahadebpur upazila of Naogaon district, Bangladesh. Appl. Ecol. Environ. Sci., 2016, 4(3), 75-83.
Chakravorty, J.; Ghosh, S.; Meyer-Rochow, V.B. Comparative survey of entomophagy and entomotherapeutic practices in six tribes of eastern Arunachal Pradesh (India). J. Ethnobiol. Ethnomed., 2013, 9(1), 50.
[] [PMID: 23866996]
Joshi, B.; Kamat, V. Structure of enhydrin, a germacranolide from Enhydra fluctuans Lour. Indian J. Chem., 1972, 8, 771-776.
Ali, E.; Dastidar, P.G.; Pakrashi, S.; Durham, L.; Duffield, A. Studies on Indian medicinal plants=XXVIII: Sesquiterpene lactones of Enhydra fluctuans Lour. Structures of enhydrin, fluctuanin and fluctuadin. Tetrahedron, 1972, 28(8), 2285-2298.
Krishnaswamy, N.; Ramji, N. Sesquiterpene lactones from Enhydra fluctuans. Phytochemistry, 1995, 38(2), 433-435.
Muselli, A.; Bighelli, A.; Minh Hoi, T.; Phuong Thao, N.T.; Huy Thai, T.; Casanova, J. Dihydroperillaldehydes from Enhydra fluctuans Lour. essential oil. Flavour Fragrance J., 2000, 15(5), 299-302.
Uddin, S.; Ferdous, M.; Rouf, R.; Alam, M.; Sarkar, M.; Shilpi, J. Evaluation of anti-diarrhoeal activity of Enhydra fluctuans. J. Med. Sci., 2005, 5(4), 324-327.
Bohlmann, F.; Ahmed, M.; Robinson, H.; King, R.M. Melampolides from Enhydra fluctuans var. Fluctuans. Phytochemistry, 1982, 21(7), 1675-1678.
Chen, L-J.; Games, D.E.; Jones, J. Isolation and identification of four flavonoid constituents from the seeds of Oroxylum indicum by high-speed counter-current chromatography. J. Chromatogr. A, 2003, 988(1), 95-105.
[] [PMID: 12647824]
Pakrashi, S.; Dastidar, P.G.; Gupta, S. Diterpenoids from Enhydra fluctuans. Phytochemistry, 1970, 9, 459.
Yadava, R.N.; Singh, S.K. Novel bioactive constituents from Enhydra fluctuans Lour. Nat. Prod. Res., 2007, 21(6), 481-486.
[] [PMID: 17497419]
Dua, T.K.; Dewanjee, S.; Khanra, R.; Joardar, S.; Barma, S.; Das, S.; Zia-Ul-Haq, M.; De Feo, V. Cytoprotective and antioxidant effects of an edible herb, Enhydra fluctuans Lour.(Asteraceae), against experimentally induced lead acetate intoxication. PLoS One, 2016, 11(2)e0148757
[] [PMID: 26859407]
Dua, T.K.; Dewanjee, S.; Khanra, R. Prophylactic role of Enhydra fluctuans against arsenic-induced hepatotoxicity via anti-apoptotic and antioxidant mechanisms. Redox Rep., 2016, 21(4), 147-154.
[] [PMID: 26066906]
Dua, T.K.; Dewanjee, S.; Khanra, R.; Bhattacharya, N.; Bhaskar, B.; Zia-Ul-Haq, M.; De Feo, V. The effects of two common edible herbs, Ipomoea aquatica and Enhydra fluctuans, on cadmium-induced pathophysiology: A focus on oxidative defence and anti-apoptotic mechanism. J. Transl. Med., 2015, 13(1), 245.
[] [PMID: 26215156]
Saha, S.; Paul, S. A review on phytochemical constituents and pharmacological properties of Enhydra fluctuans Lour. J. Pharmacogn. Phytochem., 2019, 8(2), 887-893.
Rahman, M.T.; Begum, N.; Alimuzzaman, M.; Khan, M.O. Analgesic activity of Enhydra fluctuans. Fitoterapia, 2002, 73(7-8), 707-709.
[] [PMID: 12490236]
Sannigrahi, S.; Mazumder, U.K.; Pal, D.; Mishra, M.L.; Maity, S. Flavonoids of Enhydra fluctuans exhibits analgesic and anti-inflammatory activity in different animal models. Pak. J. Pharm. Sci., 2011, 24(3), 369-375.
[PMID: 21715271]
Sannigrahi, S.; Mazumder, U.K.; Mondal, A.; Pal, D.; Mishra, S.L.; Roy, S. Flavonoids of Enhydra fluctuans exhibit anticancer activity against Ehrlich’s ascites carcinoma in mice. Nat. Prod. Commun., 2010, 5(8), 1239-1242.
[] [PMID: 20839626]
Kuri, S.; Billah, M.M.; Rana, S.M.; Naim, Z.; Islam, M.M.; Hasanuzzaman, M.; Ali, M.R.; Banik, R. Phytochemical and in vivo biological investigations of methanolic extracts of Enhydra fluctuans Lour. Asian Pac. J. Trop. Biomed., 2014, 4(4), 299-305.
[] [PMID: 25182555]
Ullah, M.O.; Haque, M.; Urmi, K.F.; Zulfiker, A.H.M.; Anita, E.S.; Begum, M.; Hamid, K. Anti-bacterial activity and brine shrimp lethality bioassay of methanolic extracts of fourteen different edible vegetables from Bangladesh. Asian Pac. J. Trop. Biomed., 2013, 3(1), 1-7.
[] [PMID: 23570009]
Amin, M.R.; Mondol, R.; Habib, M.R.; Hossain, M.T. Antimicrobial and cytotoxic activity of three bitter plants enhydra fluctuans, andrographis peniculata and clerodendrum viscosum. Adv. Pharm. Bull., 2012, 2(2), 207-211.
[PMID: 24312795]
Roy, S.K.; Mazumder, U.K.; Islam, A. Pharmacological evaluation of Enhydra fluctuans aerial parts for central nervous system depressant activity. Pharmacologyonline, 2011, 1, 632-643.
Dasgupta, N.; De, B. Antioxidant activity of some leafy vegetables of India: A comparative study. Food Chem., 2007, 101(2), 471-474.
Sannigrahi, S.; Mazumder, U.K.; Pal, D.K.; Mondal, A.; Roy, S. Hepatoprotective potential of flavonoid rich fraction of Enhydra fluctuans against CCl4-induced oxidative damage in rats. Pharmacologyonline, 2009, 2009(2), 575-586.
Kumar, G.P.; Khanum, F. Neuroprotective potential of phytochemicals. Pharmacogn. Rev., 2012, 6(12), 81-90.
[] [PMID: 23055633]
Dewanji, A.; Matai, S.; Si, L.; Barik, S.; Nag, A. Chemical composition of two semi-aquatic plants for food use. Plant Foods Hum. Nutr., 1993, 44(1), 11-16.
[] [PMID: 8332583]
Ganguly, S.; Ganguly, T.; Sircar, S. Gibberellins of Enhydra fluctuans. Phytochemistry, 1972, 11(12), 3433-3434.

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