Abstract
HMGB1/Amphoterin is a ubiquitous, highly conserved DNA-binding protein that can be also released to the extracellular space by various cell types. Extracellular HMGB1 regulates migratory responses of several cell types through binding to RAGE that communicates with the cytoskeleton to regulate cell motility. HMGB1- induced cell signalling has been associated with mechanisms of several diseases, including cancer, sepsis, rheumatoid arthritis, stroke and atherosclerosis. This article reviews the evidence linking the functional roles of HMGB1 to RAGE signalling. Furthermore, we discuss the molecular and cellular mechanisms that may explain the roles of HMGB1/RAGE in diverse disease processes.
Keywords: RAGE-binding region, HMGB1 expression, MAPK kinases, inflammation, plasticity
Current Molecular Medicine
Title: RAGE as a Receptor of HMGB1 (Amphoterin): Roles in Health and Disease
Volume: 7 Issue: 8
Author(s): Heikki Rauvala and Ari Rouhiainen
Affiliation:
Keywords: RAGE-binding region, HMGB1 expression, MAPK kinases, inflammation, plasticity
Abstract: HMGB1/Amphoterin is a ubiquitous, highly conserved DNA-binding protein that can be also released to the extracellular space by various cell types. Extracellular HMGB1 regulates migratory responses of several cell types through binding to RAGE that communicates with the cytoskeleton to regulate cell motility. HMGB1- induced cell signalling has been associated with mechanisms of several diseases, including cancer, sepsis, rheumatoid arthritis, stroke and atherosclerosis. This article reviews the evidence linking the functional roles of HMGB1 to RAGE signalling. Furthermore, we discuss the molecular and cellular mechanisms that may explain the roles of HMGB1/RAGE in diverse disease processes.
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Cite this article as:
Rauvala Heikki and Rouhiainen Ari, RAGE as a Receptor of HMGB1 (Amphoterin): Roles in Health and Disease, Current Molecular Medicine 2007; 7 (8) . https://dx.doi.org/10.2174/156652407783220750
DOI https://dx.doi.org/10.2174/156652407783220750 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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