摘要
多形性胶质母细胞瘤 (GBM) 是一种难以治愈的脑肿瘤,因为它具有极强的侵袭性。 姜黄素作为从姜黄中提取的潜在植物化学物质,已被证明具有针对多种恶性肿瘤的化学预防和抗肿瘤活性。 这些化合物通过在肿瘤进展、增殖和转移的不同阶段调节多个信号通路和分子靶点来发挥这些作用。 在实验研究中,姜黄素已显示出克服 GBM 的有希望的治疗益处。 姜黄素已被证明通过调节血管生成、细胞凋亡、自噬、转移、侵袭以及潜在的分子靶标(包括受体酪氨酸激酶、Sonic Hedgehog 和 NF-κB)发挥其抗 GBM 作用。 本研究回顾了关于姜黄素及其衍生物对 GBM 的影响以及将研究结果转化为临床的潜力的观察结果。
关键词: 多形性胶质母细胞瘤,姜黄素,抗肿瘤活性,信号通路,植物化学物质,自噬,转移,侵袭。
Current Medicinal Chemistry
Title:Anti-tumor Effects of Curcuminoids in Glioblastoma Multiforme: An Updated Literature Review
Volume: 28 Issue: 39
关键词: 多形性胶质母细胞瘤,姜黄素,抗肿瘤活性,信号通路,植物化学物质,自噬,转移,侵袭。
摘要: Glioblastoma Multiforme (GBM) is a poorly curable brain tumor because of its extremely invasive nature. Curcuminoids, as potential phytochemicals extracted from Curcuma Longa L., have been documented for their chemopreventive and antitumor activities against several types of malignancies. These compounds exert these effects via modulation of multiple signaling pathways and molecular targets at different stages of tumor progression, proliferation, and metastasis. In experimental studies, curcuminoids have demonstrated promising therapeutic benefits to overcome GBM. Curcuminoids have been shown to exert their anti-GBM effects through regulation of angiogenesis, apoptosis, autophagy, metastasis, invasion, as well as potential molecular targets, including receptor tyrosine kinases, Sonic Hedgehog, and NF-κB. This study reviews the observations regarding the impact of curcumin and its derivatives on GBM and the potential of translating the research findings into the clinic.
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Anti-tumor Effects of Curcuminoids in Glioblastoma Multiforme: An Updated Literature Review, Current Medicinal Chemistry 2021; 28 (39) . https://dx.doi.org/10.2174/0929867327666201111145212
DOI https://dx.doi.org/10.2174/0929867327666201111145212 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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