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Current Pediatric Reviews


ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

Review Article

COVID-19 and Comorbidities: Is Inflammation the Underlying Condition in Children? A Narrative Review

Author(s): Giulia Pinna, Lavinia Sanfilippo, Pier Paolo Bassareo*, Vassilios Fanos and Maria Antonietta Marcialis

Volume 17, Issue 1, 2021

Published on: 12 November, 2020

Page: [38 - 44] Pages: 7

DOI: 10.2174/1573396316666201112093920

Price: $65


This paper examines the potential link between COVID-19 and the presence of comorbidities and assesses the role of inflammation in this correlation. In COVID-19 patients, the most frequently associated diseases share a pathogenic inflammatory basis and apparently act as a risk factor in the onset of a more severe form of the disease, particularly in adulthood. However, in children, the understanding of the underlying pathogenic mechanisms is often complicated by the milder symptoms presented. A series of theories have, therefore, been put forward with a view of providing a better understanding of the role played by inflammation in this dramatic setting. All evidence available to date on this topic is discussed in this review.

Keywords: COVID-19, coronavirus, inflammation, risk factors, children, pathogenic.

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