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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Research Article

UCP2 and CFH Gene Variants with Genetic Susceptibility to Schizophrenia in Turkish Population

Author(s): Ayse Feyda Nursal*, Pinar Cetinay Aydin, Mustafa Pehlivan, Ulgen Sever and Sacide Pehlivan

Volume 21, Issue 11, 2021

Published on: 12 November, 2020

Page: [2084 - 2089] Pages: 6

DOI: 10.2174/1871530320999201113103730

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Abstract

Objective: Schizophrenia (Sch) is a complex, multifactorial psychiatric disorder. Growing evidence shows that oxidative damage and immunological dysfunction exist in the Sch physiopathology. In the present study, we aimed to evaluate whether the Uncoupling protein 2 and Complement factor H gene variants play any role in susceptibility to Sch.

Methods: This study was carried out on 200 individuals (100 Sch patients and 100 healthy controls). Genomic DNA was extracted from blood samples. UCP2-866G /A (rs659366) and CFHY402H variants were analyzed by PCR-RFLP analysis.

Results: The UCP2 -866G/A variant G/G genotype and G allele were associated significantly with increased risk of Sch (p=0.001, p=0.001, respectively). The subjects were carrying UCP2 -866G/A variant G/G genotype had 4.377-fold increased risk for Sch. There was no significant difference between the groups for the genotype and allele frequencies of the CFH Y402H variant (p>0.05). The observed genotype counts deviated significantly from those expected in Sch patients according to the HWE for UCP2 -866G/A variant (p=0.001).

Conclusion: We present the first results investigating UCP2 -866G/A/ and CFH Y402H variants for susceptibility to Sch in a Turkish population. These results indicate that the UCP2 -866G/A, but not CFH Y402H variant, might play an important role in the development of Sch.

Keywords: Schizophrenia, uncoupling protein 2, complement factor H, variant, Turkish population, genome-wide association studies.Schizophrenia, genome-wide association studies.

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