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Review Article

维生素D/VDR在急性肾损伤中的潜在治疗靶点

卷 28, 期 19, 2021

发表于: 18 November, 2020

页: [3865 - 3876] 页: 12

弟呕挨: 10.2174/0929867327666201118155625

价格: $65

摘要

尽管临床实践中使用了许多策略和参数，但急性肾损伤（AKI）的发病率和死亡率仍然很高，预后不良。随着分子生物学的发展，维生素D和维生素D受体(VDR)在AKI中的作用越来越受到重视。许多研究表明，维生素D缺乏是临床和实验性AKI的危险因素，维生素D/VDR可能是AKI的一个有前途的治疗靶点。然而，需要更多的定性临床研究，为维生素D和VDR激动剂的未来临床应用提供更有力的证据。给药途径和剂量等问题也有待更多关注。本文旨在总结维生素D/VDR在AKI中的作用，并对其治疗潜力提供一些新的见解。

关键词: 维生素D，维生素D受体，急性肾损伤，缺乏，治疗靶点，剂量。

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