Generic placeholder image

Current Drug Safety


ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

Highly Active Antiretroviral Therapy-Induced Liver Injury

Author(s): Maurizio Bonacini and Ira Inductivo-Yu

Volume 3, Issue 1, 2008

Page: [4 - 13] Pages: 10

DOI: 10.2174/157488608783333916

Price: $65


With the advent of highly active antiretroviral therapy (HAART), the reduction in overall mortality and morbidity in HIV patients has been accompanied by the emergence of liver disease as a leading cause of death. Elevated liver enzymes may be due to HAART or to other risk factors, including hepatitis co-infection and alcohol use. The different components of HAART are each associated with different risks of liver toxicity. Most drugs are metabolized by cytochrome P450 enzymes in the liver, and this may be affected by liver disease. The mechanisms for drug-induced liver injury include dose-dependent toxicity, hypersensitivity reactions, idiosyncratic reactions, mitochondrial toxicity, and immune reconstitution. The diagnosis of drug-induced liver injury is exclusionary. Once diagnosed, management generally involves discontinuation of the offending drug(s). A number of studies in progress are investigating whether treatment of hepatitis co-infection can improve the tolerability of HAART.

Keywords: Highly active antiretroviral therapy, liver injury, hepatitis co-infection

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy