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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Mini-Review Article

Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships

Author(s): Kong Zhang, Tianze Li, Xijie Shan, Rongfei Lu, Shaoyong Zhang and Hui Xu*

Volume 21, Issue 14, 2021

Published on: 05 January, 2021

Page: [1830 - 1848] Pages: 19

DOI: 10.2174/1389557521666210105123320

Price: $65


Cholesterol, steroid alcohol, was discovered by M.E. Chevreul in 1815. Cholesterol and its derivatives showed a large variety of biological properties such as anticancer activity, anticardiac activity, anti-inflammatory activity, antimicrobial activity, anti-psychotic activity, antioxidant activity, drug-loaded activity, etc. In this mini-review, the advances of structural modification of cholesterol from 2014 to 2020 are summarized. In addition, the bioactivities, mechanisms of action and structureactivity relationships of cholesterol and its related derivatives are also discussed.

Keywords: Cholesterol derivatives, biological activities, structural modification, mechanisms of action, structure-activity relationships.

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