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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Recent Advances in Small-Molecule HIV-1 Integrase Inhibitors

Author(s): Chao Zhang, Qian Xie, Chi Cheong Wan, Zhe Jin* and Chun Hu*

Volume 28, Issue 24, 2021

Published on: 14 January, 2021

Page: [4910 - 4934] Pages: 25

DOI: 10.2174/0929867328666210114124744

Price: $65


HIV-1 integrase catalyzed the insertion of viral DNA into the genome of human cells in the process of retrotranscription. Integrase is an attractive target for HIV-1 treatment due to the lack of its homologue in human cells and its vital role in HIV-1 replication. Although major progress in the development of HIV-1 integrase inhibitors has been made, some thorny problems, such as drug resistance, led to the further study of HIV-1 integrase inhibitors. This review briefly discussed the structure, function, and mechanism of catalysis of HIV-1 integrase and made a different conclusion for recent advances in small-molecule inhibitors of HIV-1 integrase.

Keywords: AIDS, integrase, HIV-1 integrase inhibitors, anti-AIDS drugs, dual inhibitors, allosteric integrase inhibitors.

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