摘要
香豆素是一种杂环苯并-α-吡喃酮和天然存在的环结构,具有显着的药理特性,吸引了研究人员和药物化学家的注意,以揭示天然和合成香豆素作为药物的适用性。已经利用基本香豆素结构合成了许多化合物。多样化的合成方法导致合成重要的香豆素衍生物,这些衍生物具有广泛的生物学特性,如抗菌、抗癌、抗炎、抗氧化、抗糖尿病和抗抑郁,使它们成为潜在的候选药物。香豆素对溃疡特别感兴趣,已显示出对脲酶的潜在抑制作用。近年来,科学家们强调香豆素的抗脲酶活性,因为它们的毒性很低。本综述的目的是收集最近关于香豆素抗脲酶活性的研究数据和香豆素环结构的构效关系研究。香豆素环中不同结构取代的研究可能有助于研究人员设计出具有强大而有效的抗脲酶能力的新化合物。
关键词: 合成香豆素、天然香豆素、药物发现、杰克豆脲酶、幽门螺杆菌、SAR。
Current Drug Targets
Title:A Review on Anti-urease Potential of Coumarins
Volume: 22 Issue: 17
关键词: 合成香豆素、天然香豆素、药物发现、杰克豆脲酶、幽门螺杆菌、SAR。
摘要: Coumarins, a heterocyclic benzo-α-pyrones and naturally occurring ring structure that possess significant pharmacological properties, have attracted the attention of researchers and medicinal chemists to reveal the suitability of both natural and synthetic coumarins as drugs. Many compounds have been synthesized utilizing the basic coumarin structure. The diverse synthetic methods resulted in the synthesis of important coumarin derivatives that offer a wide range of biological properties as antimicrobial, anticancer, anti-inflammatory, antioxidant, antidiabetic and antidepressant that make them potential drug candidates. With a particular interest in ulcers, coumarins have shown potential inhibition against urease enzyme. In recent years, scientists have emphasized the anti-urease activity of coumarins due to their low toxicity. The aim of this review is to compile data from recent research about anti-urease activities of coumarins and structure-activity relationship studies of the coumarin ring structure. Investigation of different structural substitutions in coumarin rings may help researchers to design new compounds with strong and effective anti- urease abilities.
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Cite this article as:
A Review on Anti-urease Potential of Coumarins, Current Drug Targets 2021; 22 (17) . https://dx.doi.org/10.2174/1389450122666210222091412
DOI https://dx.doi.org/10.2174/1389450122666210222091412 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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