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Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Review Article

Imaging of Spinal Bone Tumors: Principles and Practice

Author(s): Shinji Tsukamoto*, Andreas F. Mavrogenis, Kirsten van Langevelde, Niels van Vucht, Akira Kido and Costantino Errani

Volume 18, Issue 2, 2022

Published on: 01 March, 2021

Article ID: e040122191897 Pages: 20

DOI: 10.2174/1573405617666210301110446

Price: $65

Abstract

Age, location of the tumor, and detailed patient history can narrow the differential diagnosis of spinal bone lesions, including metastasis and primary benign and malignant bone tumors. Computed tomography and magnetic resonance imaging are both crucial in evaluating the characteristics of spinal bone tumors. Growth speed and Lodwick margin description can differentiate malignant from benign tumors to a certain degree. Positron emission tomography has a limited ability to differentiate malignant from benign tumors. A biopsy is often required for a definitive diagnosis. To select the optimal treatment for spinal metastasis, neurological status by epidural spinal cord compression grade (axial T2-weighted magnetic resonance image), radiosensitivity of tumor histology, mechanical instability by Spine Instability Neoplastic Score (sagittal and axial computed tomography image), and systemic disease should be evaluated by a multidisciplinary team. This review article summarizes the role of imaging for diagnosis and treatment of spinal bone tumors.

Keywords: Imaging, spine, vertebra, sarcoma, metastasis, MRI, CT, PET.

Graphical Abstract
[1]
Kelley SP, Ashford RU, Rao AS, Dickson RA. Primary bone tumours of the spine: a 42-year survey from the Leeds Regional Bone Tumour Registry. Eur Spine J 2007; 16(3): 405-9.
[http://dx.doi.org/10.1007/s00586-006-0188-7] [PMID: 16865376]
[2]
Weinstein JN, McLain RF. Primary tumors of the spine. Spine 1987; 12(9): 843-51.
[http://dx.doi.org/10.1097/00007632-198711000-00004] [PMID: 3441830]
[3]
Wang K, Allen L, Fung E, Chan CC, Chan JCS, Griffith JF. Bone scintigraphy in common tumors with osteolytic components. Clin Nucl Med 2005; 30(10): 655-71.
[http://dx.doi.org/10.1097/01.rlu.0000178027.20780.95] [PMID: 16166837]
[4]
Sundaresan N, Rosen G, Boriani S. Primary malignant tumors of the spine. Orthop Clin North Am 2009; 40(1): 21-36, v.
[http://dx.doi.org/10.1016/j.ocl.2008.10.004] [PMID: 19064053]
[5]
Batouli A, Gholamrezanezhad A, Petrov D, Rudkin S, Matcuk G, Jadvar H. Management of primary osseous spinal tumors with PET. PET Clin 2019; 14(1): 91-101.
[http://dx.doi.org/10.1016/j.cpet.2018.08.002] [PMID: 30420225]
[6]
Kim HJ, Ryu KN, Choi WS, Choi BK, Choi JM, Yoon Y. Spinal involvement of hematopoietic malignancies and metastasis: differentiation using MR imaging. Clin Imaging 1999; 23(2): 125-33.
[http://dx.doi.org/10.1016/S0899-7071(99)00105-9] [PMID: 10416091]
[7]
Gasbarrini A, Cappuccio M, Mirabile L, et al. Spinal metastases: treatment evaluation algorithm. Eur Rev Med Pharmacol Sci 2004; 8(6): 265-74.
[PMID: 15745386]
[8]
Choi D, Crockard A, Bunger C, et al. Global Spine Tumor Study Group. Review of metastatic spine tumour classification and indications for surgery: the consensus statement of the Global Spine Tumour Study Group. Eur Spine J 2010; 19(2): 215-22.
[http://dx.doi.org/10.1007/s00586-009-1252-x] [PMID: 20039084]
[9]
Rodallec MH, Feydy A, Larousserie F, et al. Diagnostic imaging of solitary tumors of the spine: what to do and say. Radiographics 2008; 28(4): 1019-41.
[http://dx.doi.org/10.1148/rg.284075156] [PMID: 18635627]
[10]
Kwon JW, Chung HW, Cho EY, et al. MRI findings of giant cell tumors of the spine. AJR Am J Roentgenol 2007; 189(1): 246-50.
[http://dx.doi.org/10.2214/AJR.06.1472] [PMID: 17579178]
[11]
Boriani S, De Iure F, Campanacci L, et al. Aneurysmal bone cyst of the mobile spine: report on 41 cases. Spine 2001; 26(1): 27-35.
[http://dx.doi.org/10.1097/00007632-200101010-00007] [PMID: 11148642]
[12]
Ozaki T, Flege S, Liljenqvist U, et al. Osteosarcoma of the spine: experience of the Cooperative Osteosarcoma Study Group. Cancer 2002; 94(4): 1069-77.
[http://dx.doi.org/10.1002/cncr.10258] [PMID: 11920477]
[13]
Ilaslan H, Sundaram M, Unni KK, Dekutoski MB. Primary Ewing’s sarcoma of the vertebral column. Skeletal Radiol 2004; 33(9): 506-13.
[http://dx.doi.org/10.1007/s00256-004-0810-x] [PMID: 15232658]
[14]
Kroon HM, Schurmans J. Osteoblastoma: clinical and radiologic findings in 98 new cases. Radiology 1990; 175(3): 783-90.
[http://dx.doi.org/10.1148/radiology.175.3.2343130] [PMID: 2343130]
[15]
Beer SJ, Menezes AH. Primary tumors of the spine in children. Natural history, management, and long-term follow-up. Spine 1997; 22(6): 649-58.
[http://dx.doi.org/10.1097/00007632-199703150-00015] [PMID: 9089938]
[16]
Rich JA, Donahue TC, Mick TJ. Symptomatic expansile vertebral hemangioma causing conus medullaris compression. J Manipulative Physiol Ther 2005; 28(3): 194-8.
[http://dx.doi.org/10.1016/j.jmpt.2005.02.017] [PMID: 15855908]
[17]
Davies A, Saifuddin A. Imaging of painful scoliosis. Skeletal Radiol 2009; 38(3): 207-23.
[http://dx.doi.org/10.1007/s00256-008-0517-5] [PMID: 18622610]
[18]
Alyas F, Saifuddin A, Connell D. MR imaging evaluation of the bone marrow and marrow infiltrative disorders of the lumbar spine. Magn Reson Imaging Clin N Am 2007; 15(2): 199-219.
[http://dx.doi.org/10.1016/j.mric.2007.03.002] [PMID: 17599640]
[19]
Parker BR, Marglin S, Castellino RA. Skeletal manifestations of leukemia, Hodgkin disease, and non-Hodgkin lymphoma. Semin Roentgenol 1980; 15(4 Pt 2): 302-15.
[http://dx.doi.org/10.1016/0037-198X(80)90026-7] [PMID: 7001642]
[20]
Chokshi FH, Law M, Gibbs WN. Conventional and Advanced Imaging of Spine Oncologic Disease, Nonoperative Post-treatment Effects, and Unique Spinal Conditions. Neurosurgery 2018; 82(1): 1-23.
[http://dx.doi.org/10.1093/neuros/nyx491] [PMID: 29029304]
[21]
Tsukamoto S, Errani C, Facchini F, Papagelopoulos P, Mavrogenis AF. Fluid-fluid levels in musculoskeletal tumor imaging. Curr Med Imaging 2021. Epub ahead of Print.
[http://dx.doi.org/10.2174/1573405616666200806173258]
[22]
Tomasian A, Wallace AN, Jennings JW. Benign spine lesions: Advances in techniques for minimally invasive percutaneous treatment. AJNR Am J Neuroradiol 2017; 38(5): 852-61.
[http://dx.doi.org/10.3174/ajnr.A5084] [PMID: 28183835]
[23]
Bernard SA, Brian PL, Flemming DJ. Primary osseous tumors of the spine. Semin Musculoskelet Radiol 2013; 17(2): 203-20.
[http://dx.doi.org/10.1055/s-0033-1343097] [PMID: 23673551]
[24]
Khoo MMY, Tyler PA, Saifuddin A, Padhani AR. Diffusion-weighted imaging (DWI) in musculoskeletal MRI: a critical review. Skeletal Radiol 2011; 40(6): 665-81.
[http://dx.doi.org/10.1007/s00256-011-1106-6] [PMID: 21311884]
[25]
van Vucht N, Santiago R, Lottmann B, et al. The Dixon technique for MRI of the bone marrow. Skeletal Radiol 2019; 48(12): 1861-74.
[http://dx.doi.org/10.1007/s00256-019-03271-4] [PMID: 31309243]
[26]
Missenard G, Bouthors C, Fadel E, Court C. Surgical strategies for primary malignant tumors of the thoracic and lumbar spine. Orthop Traumatol Surg Res 2020; 106(1S): S53-62.
[http://dx.doi.org/10.1016/j.otsr.2019.05.028] [PMID: 31843511]
[27]
Fayad LM, Jacobs MA, Wang X, Carrino JA, Bluemke DA. Musculoskeletal tumors: how to use anatomic, functional, and metabolic MR techniques. Radiology 2012; 265(2): 340-56.
[http://dx.doi.org/10.1148/radiol.12111740] [PMID: 23093707]
[28]
Traina F, Errani C, Toscano A, et al. Current concepts in the biopsy of musculoskeletal tumors: AAOS exhibit selection. J Bone Joint Surg Am 2015; 97(2): e7.
[http://dx.doi.org/10.2106/JBJS.N.00661] [PMID: 25609446]
[29]
Errani C, Traina F, Perna F, Calamelli C, Faldini C. Current concepts in the biopsy of musculoskeletal tumors. ScientificWorldJournal 2013; 2013: 538152.
[http://dx.doi.org/10.1155/2013/538152] [PMID: 23844403]
[30]
Schulte M, Brecht-Krauss D, Heymer B, et al. Grading of tumors and tumorlike lesions of bone: evaluation by FDG PET. J Nucl Med 2000; 41(10): 1695-701.
[PMID: 11038000]
[31]
Enneking WF, Spanier SS, Goodman MA. A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res 1980; (153): 106-20.
[http://dx.doi.org/10.1097/00003086-198011000-00013] [PMID: 7449206]
[32]
Enneking WF. A system of staging musculoskeletal neoplasms. Clin Orthop Relat Res 1986; (204): 9-24.
[PMID: 3456859]
[33]
Hart RA, Boriani S, Biagini R, Currier B, Weinstein JN. A system for surgical staging and management of spine tumors. A clinical outcome study of giant cell tumors of the spine. Spine 1997; 22(15): 1773-82.
[http://dx.doi.org/10.1097/00007632-199708010-00018] [PMID: 9259790]
[34]
Boriani S, Weinstein JN, Biagini R. Primary bone tumors of the spine. Terminology and surgical staging. Spine 1997; 22(9): 1036-44.
[http://dx.doi.org/10.1097/00007632-199705010-00020] [PMID: 9152458]
[35]
Chan P, Boriani S, Fourney DR, et al. An assessment of the reliability of the Enneking and Weinstein-Boriani-Biagini classifications for staging of primary spinal tumors by the Spine Oncology Study Group. Spine 2009; 34(4): 384-91.
[http://dx.doi.org/10.1097/BRS.0b013e3181971283] [PMID: 19214098]
[36]
Lodwick GS, Wilson AJ, Farrell C, Virtama P, Dittrich F. Determining growth rates of focal lesions of bone from radiographs. Radiology 1980; 134(3): 577-83.
[http://dx.doi.org/10.1148/radiology.134.3.6928321] [PMID: 6928321]
[37]
Fisher CG, Saravanja DD, Dvorak MF, et al. Surgical management of primary bone tumors of the spine: validation of an approach to enhance cure and reduce local recurrence. Spine 2011; 36(10): 830-6.
[http://dx.doi.org/10.1097/BRS.0b013e3181e502e5] [PMID: 20714276]
[38]
Katonis P, Datsis G, Karantanas A, et al. Spinal osteosarcoma. Clin Med Insights Oncol 2013; 7: 199-208.
[http://dx.doi.org/10.4137/CMO.S10099] [PMID: 24179411]
[39]
Saifuddin A, Twinn P, Emanuel R, Cannon SR. An audit of MRI for bone and soft-tissue tumours performed at referral centres. Clin Radiol 2000; 55(7): 537-41.
[http://dx.doi.org/10.1053/crad.1999.0481] [PMID: 10924378]
[40]
Seeger LL, Widoff BE, Bassett LW, Rosen G, Eckardt JJ. Preoperative evaluation of osteosarcoma: value of gadopentetate dimeglumine-enhanced MR imaging. AJR Am J Roentgenol 1991; 157(2): 347-51.
[http://dx.doi.org/10.2214/ajr.157.2.1853820] [PMID: 1853820]
[41]
Khaw FM, Worthy SA, Gibson MJ, Gholkar A. The appearance on MRI of vertebrae in acute compression of the spinal cord due to metastases. J Bone Joint Surg Br 1999; 81(5): 830-4.
[http://dx.doi.org/10.1302/0301-620X.81B5.0810830] [PMID: 10530845]
[42]
Albano D, Messina C, Gitto S, Papakonstantinou O, Sconfienza LM. Differential diagnosis of spine tumors: My favorite mistake. Semin Musculoskelet Radiol 2019; 23(1): 26-35.
[http://dx.doi.org/10.1055/s-0038-1675551] [PMID: 30699451]
[43]
Dormans JP, Moroz L. Infection and tumors of the spine in children. J Bone Joint Surg Am 2007; 89(Suppl. 1): 79-97.
[PMID: 17272426]
[44]
Errani C, Vanel D, Gambarotti M, Alberghini M, Picci P, Faldini C. Vascular bone tumors: a proposal of a classification based on clinicopathological, radiographic and genetic features. Skeletal Radiol 2012; 41(12): 1495-507.
[http://dx.doi.org/10.1007/s00256-012-1510-6] [PMID: 22993209]
[45]
Liu X-W, Jin P, Wang L-J, Li M, Sun G. Vertebroplasty in the treatment of symptomatic vertebral haemangiomas without neurological deficit. Eur Radiol 2013; 23(9): 2575-81.
[http://dx.doi.org/10.1007/s00330-013-2843-9] [PMID: 23620368]
[46]
Fox MW, Onofrio BM. The natural history and management of symptomatic and asymptomatic vertebral hemangiomas. J Neurosurg 1993; 78(1): 36-45.
[http://dx.doi.org/10.3171/jns.1993.78.1.0036] [PMID: 8416240]
[47]
Doppman JL, Oldfield EH, Heiss JD. Symptomatic vertebral hemangiomas: treatment by means of direct intralesional injection of ethanol. Radiology 2000; 214(2): 341-8.
[http://dx.doi.org/10.1148/radiology.214.2.r00fe46341] [PMID: 10671579]
[48]
Bandiera S, Gasbarrini A, De Iure F, Cappuccio M, Picci P, Boriani S. Symptomatic vertebral hemangioma: the treatment of 23 cases and a review of the literature. Chir Organi Mov 2002; 87(1): 1-15.
[PMID: 12198945]
[49]
Cotten A, Deramond H, Cortet B, et al. Preoperative percutaneous injection of methyl methacrylate and N-butyl cyanoacrylate in vertebral hemangiomas. AJNR Am J Neuroradiol 1996; 17(1): 137-42.
[PMID: 8770265]
[50]
Gold RH, Mirra JM, Remotti F, Pignatti G. Case report 527: Giant bone island of tibia. Skeletal Radiol 1989; 18(2): 129-32.
[http://dx.doi.org/10.1007/BF00350662] [PMID: 2717952]
[51]
Greenspan A. Bone island (enostosis): current concept- a review. Skeletal Radiol 1995; 24(2): 111-5.
[http://dx.doi.org/10.1007/BF00198072] [PMID: 7747175]
[52]
Theodorou DJ, Theodorou SJ, Sartoris DJ. An imaging overview of primary tumors of the spine: Part 1. Benign tumors. Clin Imaging 2008; 32(3): 196-203.
[http://dx.doi.org/10.1016/j.clinimag.2007.09.011] [PMID: 18502347]
[53]
Greenspan A, Steiner G, Knutzon R. Bone island (enostosis): clinical significance and radiologic and pathologic correlations. Skeletal Radiol 1991; 20(2): 85-90.
[http://dx.doi.org/10.1007/BF00193816] [PMID: 1902324]
[54]
Sala F, Dapoto A, Morzenti C, et al. Bone islands incidentally detected on computed tomography: frequency of enostosis and differentiation from untreated osteoblastic metastases based on CT attenuation value. Br J Radiol 2019; 92(1103): 20190249.
[http://dx.doi.org/10.1259/bjr.20190249] [PMID: 31469323]
[55]
Rosenthal DI, Alexander A, Rosenberg AE, Springfield D. Ablation of osteoid osteomas with a percutaneously placed electrode: a new procedure. Radiology 1992; 183(1): 29-33.
[http://dx.doi.org/10.1148/radiology.183.1.1549690] [PMID: 1549690]
[56]
Weber M-A, Sprengel SD, Omlor GW, et al. Clinical long-term outcome, technical success, and cost analysis of radiofrequency ablation for the treatment of osteoblastomas and spinal osteoid osteomas in comparison to open surgical resection. Skeletal Radiol 2015; 44(7): 981-93.
[http://dx.doi.org/10.1007/s00256-015-2139-z] [PMID: 25910709]
[57]
Hempfing A, Hoffend J, Bitsch RG, Bernd L. The indication for gamma probe-guided surgery of spinal osteoid osteomas. Eur Spine J 2007; 16(10): 1668-72.
[http://dx.doi.org/10.1007/s00586-007-0388-9] [PMID: 17479302]
[58]
Rosenthal DI, Hornicek FJ, Torriani M, Gebhardt MC, Mankin HJ. Osteoid osteoma: percutaneous treatment with radiofrequency energy. Radiology 2003; 229(1): 171-5.
[http://dx.doi.org/10.1148/radiol.2291021053] [PMID: 12944597]
[59]
Ghanem I. The management of osteoid osteoma: updates and controversies. Curr Opin Pediatr 2006; 18(1): 36-41.
[http://dx.doi.org/10.1097/01.mop.0000193277.47119.15] [PMID: 16470160]
[60]
Lindner NJ, Ozaki T, Roedl R, Gosheger G, Winkelmann W, Wörtler K. Percutaneous radiofrequency ablation in osteoid osteoma. J Bone Joint Surg Br 2001; 83(3): 391-6.
[http://dx.doi.org/10.1302/0301-620X.83B3.0830391] [PMID: 11341426]
[61]
Rybak LD, Gangi A, Buy X, La Rocca Vieira R, Wittig J. Thermal ablation of spinal osteoid osteomas close to neural elements: technical considerations. AJR Am J Roentgenol 2010; 195(4): W293-8.
[http://dx.doi.org/10.2214/AJR.10.4192] [PMID: 20858792]
[62]
Whitmore MJ, Hawkins CM, Prologo JD, et al. Cryoablation of Osteoid Osteoma in the Pediatric and Adolescent Population. J Vasc Interv Radiol 2016; 27(2): 232-7.
[http://dx.doi.org/10.1016/j.jvir.2015.10.005] [PMID: 26683456]
[63]
Van Royen BJ, Baayen JC, Pijpers R, Noske DP, Schakenraad D, Wuisman PIJM. Osteoid osteoma of the spine: a novel technique using combined computer-assisted and gamma probe-guided high-speed intralesional drill excision. Spine 2005; 30(3): 369-73.
[http://dx.doi.org/10.1097/01.brs.0000152531.49095.34] [PMID: 15682022]
[64]
Rehnitz C, Sprengel SD, Lehner B, et al. CT-guided radiofrequency ablation of osteoid osteoma and osteoblastoma: clinical success and long-term follow up in 77 patients. Eur J Radiol 2012; 81(11): 3426-34.
[http://dx.doi.org/10.1016/j.ejrad.2012.04.037] [PMID: 22770580]
[65]
Tsoumakidou G, Koch G, Caudrelier J, et al. Image-Guided Spinal Ablation: A Review. Cardiovasc Intervent Radiol 2016; 39(9): 1229-38.
[http://dx.doi.org/10.1007/s00270-016-1402-6] [PMID: 27329231]
[66]
Rybak LD. Fire and ice: thermal ablation of musculoskeletal tumors. Radiol Clin North Am 2009; 47(3): 455-69.
[http://dx.doi.org/10.1016/j.rcl.2008.12.006] [PMID: 19361670]
[67]
Mesfin A, Boriani S, Gambarotti M, Bandiera S, Gasbarrini A. Can Osteoblastoma Evolve to Malignancy? A Challenge in the Decision-Making Process of a Benign Spine Tumor. World Neurosurg 2020; 136: 150-6.
[http://dx.doi.org/10.1016/j.wneu.2019.11.148] [PMID: 31809897]
[68]
Fletcher CDM, Bridge JA, Hogendoorn P, Mertens F. WHO Classification of tumours of soft tissue and bone. Lyon: IARC 2020.
[69]
Goldenberg RR, Campbell CJ, Bonfiglio M. Giant-cell tumor of bone. An analysis of two hundred and eighteen cases. J Bone Joint Surg Am 1970; 52(4): 619-64.
[http://dx.doi.org/10.2106/00004623-197052040-00001] [PMID: 5479455]
[70]
Larsson SE, Lorentzon R, Boquist L. Giant-cell tumor of bone. A demographic, clinical, and histopathological study of all cases recorded in the Swedish Cancer Registry for the years 1958 through 1968. J Bone Joint Surg Am 1975; 57(2): 167-73.
[http://dx.doi.org/10.2106/00004623-197557020-00007] [PMID: 1112843]
[71]
Tsukamoto S, Mavrogenis AF, Tanzi P, et al. Curettage as first surgery for bone giant cell tumor : adequate surgery is more important than oncology training or surgical management by high volume specialized teams. Eur J Orthop Surg Traumatol 2020; 30(1): 3-9.
[http://dx.doi.org/10.1007/s00590-019-02535-y] [PMID: 31520122]
[72]
Errani C, Tsukamoto S, Leone G, et al. Higher local recurrence rates after intralesional surgery for giant cell tumor of the proximal femur compared to other sites. Eur J Orthop Surg Traumatol 2017; 27(6): 813-9.
[http://dx.doi.org/10.1007/s00590-017-1983-z] [PMID: 28589498]
[73]
Fidler MW. Surgical treatment of giant cell tumours of the thoracic and lumbar spine: report of nine patients. Eur Spine J 2001; 10(1): 69-77.
[http://dx.doi.org/10.1007/s005860000206] [PMID: 11276839]
[74]
Boriani S, Bandiera S, Casadei R, et al. Giant cell tumor of the mobile spine: a review of 49 cases. Spine 2012; 37(1): E37-45.
[http://dx.doi.org/10.1097/BRS.0b013e3182233ccd] [PMID: 22179322]
[75]
Charest-Morin R, Fisher CG, Varga PP, et al. AOSpine knowledge forum tumor. En Bloc resection versus intralesional surgery in the treatment of giant cell tumor of the spine. Spine 2017; 42(18): 1383-90.
[http://dx.doi.org/10.1097/BRS.0000000000002094] [PMID: 28146024]
[76]
Chawla S, Henshaw R, Seeger L, et al. Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: interim analysis of an open-label, parallel- group, phase 2 study. Lancet Oncol 2013; 14(9): 901-8.
[http://dx.doi.org/10.1016/S1470-2045(13)70277-8] [PMID: 23867211]
[77]
Goldschlager T, Dea N, Boyd M, et al. Giant cell tumors of the spine: has denosumab changed the treatment paradigm? J Neurosurg Spine 2015; 22(5): 526-33.
[http://dx.doi.org/10.3171/2014.10.SPINE13937] [PMID: 25700239]
[78]
Sambri A, Medellin MR, Errani C, et al. Denosumab in giant cell tumour of bone in the pelvis and sacrum: Long-term therapy or bone resection? J Orthop Sci 2020; 25(3): 513-9.
[http://dx.doi.org/10.1016/j.jos.2019.05.003] [PMID: 31155442]
[79]
Hosalkar HS, Jones KJ, King JJ, Lackman RD. Serial arterial embolization for large sacral giant-cell tumors: mid- to long-term results. Spine 2007; 32(10): 1107-15.
[http://dx.doi.org/10.1097/01.brs.0000261558.94247.8d] [PMID: 17471094]
[80]
Tsoumakidou G, Too CW, Garnon J, Steib J-P, Gangi A. Treatment of a spinal aneurysmal bone cyst using combined image-guided cryoablation and cementoplasty. Skeletal Radiol 2015; 44(2): 285-9.
[http://dx.doi.org/10.1007/s00256-014-1967-6] [PMID: 25091121]
[81]
Griauzde J, Gemmete JJ, Farley F. Successful treatment of a Musculoskeletal Tumor Society grade 3 aneurysmal bone cyst with N-butyl cyanoacrylate embolization and percutaneous cryoablation. J Vasc Interv Radiol 2015; 26(6): 905-9.
[http://dx.doi.org/10.1016/j.jvir.2015.01.019] [PMID: 26003456]
[82]
Rossi G, Rimondi E, Bartalena T, et al. Selective arterial embolization of 36 aneurysmal bone cysts of the skeleton with N-2-butyl cyanoacrylate. Skeletal Radiol 2010; 39(2): 161-7.
[http://dx.doi.org/10.1007/s00256-009-0757-z] [PMID: 19669138]
[83]
Amendola L, Simonetti L, Simoes CE, Bandiera S, De Iure F, Boriani S. Aneurysmal bone cyst of the mobile spine: the therapeutic role of embolization. Eur Spine J 2013; 22(3): 533-41.
[http://dx.doi.org/10.1007/s00586-012-2566-7] [PMID: 23135793]
[84]
Rossi G, Mavrogenis AF, Facchini G, et al. How effective is embolization with N-2-butyl-cyanoacrylate for aneurysmal bone cysts? Int Orthop 2017; 41(8): 1685-92.
[http://dx.doi.org/10.1007/s00264-016-3364-3] [PMID: 27933423]
[85]
Peeters SP, Van der Geest ICM, de Rooy JWJ, Veth RPH, Schreuder HWB. Aneurysmal bone cyst: the role of cryosurgery as local adjuvant treatment. J Surg Oncol 2009; 100(8): 719-24.
[http://dx.doi.org/10.1002/jso.21410] [PMID: 19821494]
[86]
Malawer MM, Dunham W. Cryosurgery and acrylic cementation as surgical adjuncts in the treatment of aggressive (benign) bone tumors. Analysis of 25 patients below the age of 21. Clin Orthop Relat Res 1991; (262): 42-57.
[PMID: 1984931]
[87]
Ozaki T, Hillmann A, Lindner N, Winkelmann W. Cementation of primary aneurysmal bone cysts. Clin Orthop Relat Res 1997; (337): 240-8.
[http://dx.doi.org/10.1097/00003086-199704000-00026] [PMID: 9137195]
[88]
Varshney MK, Rastogi S, Khan SA, Trikha V. Is sclerotherapy better than intralesional excision for treating aneurysmal bone cysts? Clin Orthop Relat Res 2010; 468(6): 1649-59.
[http://dx.doi.org/10.1007/s11999-009-1144-8] [PMID: 19851815]
[89]
Rastogi S, Varshney MK, Trikha V, Khan SA, Choudhury B, Safaya R. Treatment of aneurysmal bone cysts with percutaneous sclerotherapy using polidocanol. A review of 72 cases with long-term follow-up. J Bone Joint Surg Br 2006; 88(9): 1212-6.
[http://dx.doi.org/10.1302/0301-620X.88B9.17829] [PMID: 16943475]
[90]
Adamsbaum C, Mascard E, Guinebretière JM, Kalifa G, Dubousset J. Intralesional Ethibloc injections in primary aneurysmal bone cysts: an efficient and safe treatment. Skeletal Radiol 2003; 32(10): 559-66.
[http://dx.doi.org/10.1007/s00256-003-0653-x] [PMID: 12856159]
[91]
Topouchian V, Mazda K, Hamze B, Laredo J-D, Penneçot G-F. Aneurysmal bone cysts in children: complications of fibrosing agent injection. Radiology 2004; 232(2): 522-6.
[http://dx.doi.org/10.1148/radiol.2322031157] [PMID: 15215542]
[92]
Shiels WE II, Mayerson JL. Percutaneous doxycycline treatment of aneurysmal bone cysts with low recurrence rate: a preliminary report. Clin Orthop Relat Res 2013; 471(8): 2675-83.
[http://dx.doi.org/10.1007/s11999-013-3043-2] [PMID: 23670673]
[93]
Guarnieri G, Vassallo P, Muto M, Muto M. Percutaneous treatment of symptomatic aneurysmal bone cyst of L5 by percutaneous injection of osteoconductive material (Cerament). J Neurointerv Surg 2014; 6(8): e43.
[http://dx.doi.org/10.1136/neurintsurg-2013-010912.rep] [PMID: 24211854]
[94]
Cornelis F, Truchetet ME, Amoretti N, et al. Bisphosphonate therapy for unresectable symptomatic benign bone tumors: a long-term prospective study of tolerance and efficacy. Bone 2014; 58: 11-6.
[http://dx.doi.org/10.1016/j.bone.2013.10.004] [PMID: 24120668]
[95]
Palmerini E, Ruggieri P, Angelini A, et al. Denosumab in patients with aneurysmal bone cysts: A case series with preliminary results. Tumori 2018; 104(5): 344-51.
[http://dx.doi.org/10.1177/0300891618784808] [PMID: 30086700]
[96]
Ravindra VM, Eli IM, Schmidt MH, Brockmeyer DL. Primary osseous tumors of the pediatric spinal column: review of pathology and surgical decision making. Neurosurg Focus 2016; 41(2): E3.
[http://dx.doi.org/10.3171/2016.5.FOCUS16155] [PMID: 27476845]
[97]
Albrecht S, Crutchfield JS, SeGall GK. On spinal osteochondromas. J Neurosurg 1992; 77(2): 247-52.
[http://dx.doi.org/10.3171/jns.1992.77.2.0247] [PMID: 1625013]
[98]
Zaijun L, Xinhai Y, Zhipeng W, et al. Outcome and prognosis of myelopathy and radiculopathy from osteochondroma in the mobile spine: a report on 14 patients. J Spinal Disord Tech 2013; 26(4): 194-9.
[http://dx.doi.org/10.1097/BSD.0b013e31823eb239] [PMID: 22124421]
[99]
Sharma MC, Arora R, Deol PS, Mahapatra AK, Mehta VS, Sarkar C. Osteochondroma of the spine: an enigmatic tumor of the spinal cord. A series of 10 cases. J Neurosurg Sci 2002; 46(2): 66-70.
[PMID: 12232551]
[100]
Harris WH, Dudley HR Jr, Barry RJ. The natural history of fibrous dysplasia. An orthopaedic, pathological, and roentgenographic study. J Bone Joint Surg Am 1962; 44-A: 207-33.
[http://dx.doi.org/10.2106/00004623-196244020-00001] [PMID: 14036060]
[101]
Ropper AE, Cahill KS, Hanna JW, McCarthy EF, Gokaslan ZL, Chi JH. Primary vertebral tumors: a review of epidemiologic, histological, and imaging findings, Part I: benign tumors. Neurosurgery 2011; 69(6): 1171-80.
[http://dx.doi.org/10.1227/NEU.0b013e31822b8107] [PMID: 21725252]
[102]
Chanson P, Salenave S, Orcel P. McCune-Albright syndrome in adulthood. Pediatr Endocrinol Rev 2007; 4(Suppl. 4): 453-62.
[PMID: 17982395]
[103]
Medow JE, Agrawal BM, Resnick DK. Polyostotic fibrous dysplasia of the cervical spine: case report and review of the literature. Spine J 2007; 7(6): 712-5.
[http://dx.doi.org/10.1016/j.spinee.2006.10.023] [PMID: 17434805]
[104]
Kanter AS, Jagannathan J, Shaffrey CI, Ouellet JA, Mummaneni PV. Inflammatory and dysplastic lesions involving the spine. Neurosurg Clin N Am 2008; 19(1): 93-109.
[http://dx.doi.org/10.1016/j.nec.2007.08.002] [PMID: 18156052]
[105]
Chapurlat RD. Medical therapy in adults with fibrous dysplasia of bone. J Bone Miner Res 2006; 21(Suppl. 2): 114-9.
[http://dx.doi.org/10.1359/jbmr.06s222] [PMID: 17228999]
[106]
Xin X, Feng J, Yue C, Jin T, Liu X. Monostotic fibrous dysplasia at C7 treated with vertebroplasty: a case report and review of the literature. World J Surg Oncol 2019; 17(1): 186.
[http://dx.doi.org/10.1186/s12957-019-1717-2] [PMID: 31706319]
[107]
Bertram C, Madert J, Eggers C. Eosinophilic granuloma of the cervical spine. Spine 2002; 27(13): 1408-13.
[http://dx.doi.org/10.1097/00007632-200207010-00007] [PMID: 12131737]
[108]
Per H, Koç KR, Gümüş H, Canpolat M, Kumandaş S. Cervical eosinophilic granuloma and torticollis: a case report and review of the literature. J Emerg Med 2008; 35(4): 389-92.
[http://dx.doi.org/10.1016/j.jemermed.2007.10.026] [PMID: 18353598]
[109]
Garg S, Mehta S, Dormans JP. Langerhans cell histiocytosis of the spine in children. Long-term follow-up. J Bone Joint Surg Am 2004; 86(8): 1740-50.
[http://dx.doi.org/10.2106/00004623-200408000-00019] [PMID: 15292423]
[110]
Floman Y, Bar-On E, Mosheiff R, Mirovsky Y, Robin GC, Ramu N. Eosinophilic granuloma of the spine. J Pediatr Orthop B 1997; 6(4): 260-5.
[http://dx.doi.org/10.1097/01202412-199710000-00008] [PMID: 9343786]
[111]
Azouz EM, Saigal G, Rodriguez MM, Podda A. Langerhans’ cell histiocytosis: pathology, imaging and treatment of skeletal involvement. Pediatr Radiol 2005; 35(2): 103-15.
[http://dx.doi.org/10.1007/s00247-004-1262-0] [PMID: 15289942]
[112]
Haupt R, Minkov M, Astigarraga I, et al. Euro Histio Network. Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years. Pediatr Blood Cancer 2013; 60(2): 175-84.
[http://dx.doi.org/10.1002/pbc.24367] [PMID: 23109216]
[113]
A multicentre retrospective survey of Langerhans’ cell histiocytosis: 348 cases observed between 1983 and 1993. The French Langerhans’ Cell Histiocytosis Study Group. Arch Dis Child 1996; 75(1): 17-24.
[http://dx.doi.org/10.1136/adc.75.1.17] [PMID: 8813865]
[114]
Murphey MD, Andrews CL, Flemming DJ, Temple HT, Smith WS, Smirniotopoulos JG. From the archives of the AFIP. Primary tumors of the spine: radiologic pathologic correlation. Radiographics 1996; 16(5): 1131-58.
[http://dx.doi.org/10.1148/radiographics.16.5.8888395] [PMID: 8888395]
[115]
Chugh R, Tawbi H, Lucas DR, Biermann JS, Schuetze SM, Baker LH. Chordoma: the nonsarcoma primary bone tumor. Oncologist 2007; 12(11): 1344-50.
[http://dx.doi.org/10.1634/theoncologist.12-11-1344] [PMID: 18055855]
[116]
Smith J, Ludwig RL, Marcove RC. Sacrococcygeal chordoma. A clinicoradiological study of 60 patients. Skeletal Radiol 1987; 16(1): 37-44.
[http://dx.doi.org/10.1007/BF00349926] [PMID: 3823959]
[117]
Smolders D, Wang X, Drevelengas A, Vanhoenacker F, De Schepper AM. Value of MRI in the diagnosis of non-clival, non-sacral chordoma. Skeletal Radiol 2003; 32(6): 343-50.
[http://dx.doi.org/10.1007/s00256-003-0633-1] [PMID: 12719927]
[118]
de Bruïne FT, Kroon HM. Spinal chordoma: radiologic features in 14 cases. AJR Am J Roentgenol 1988; 150(4): 861-3.
[http://dx.doi.org/10.2214/ajr.150.4.861] [PMID: 3258100]
[119]
Sung MS, Lee GK, Kang HS, et al. Sacrococcygeal chordoma: MR imaging in 30 patients. Skeletal Radiol 2005; 34(2): 87-94.
[http://dx.doi.org/10.1007/s00256-004-0840-4] [PMID: 15480648]
[120]
Boriani S, Bandiera S, Biagini R, et al. Chordoma of the mobile spine: fifty years of experience. Spine 2006; 31(4): 493-503.
[http://dx.doi.org/10.1097/01.brs.0000200038.30869.27] [PMID: 16481964]
[121]
Aibe N, Demizu Y, Sulaiman NS, et al. Outcomes of patients with primary sacral chordoma treated with definitive proton beam therapy. Int J Radiat Oncol Biol Phys 2018; 100(4): 972-9.
[http://dx.doi.org/10.1016/j.ijrobp.2017.12.263] [PMID: 29485077]
[122]
Nishida Y, Kamada T, Imai R, et al. Clinical outcome of sacral chordoma with carbon ion radiotherapy compared with surgery. Int J Radiat Oncol Biol Phys 2011; 79(1): 110-6.
[http://dx.doi.org/10.1016/j.ijrobp.2009.10.051] [PMID: 20400242]
[123]
Shives TC, McLeod RA, Unni KK, Schray MF. Chondrosarcoma of the spine. J Bone Joint Surg Am 1989; 71(8): 1158-65.
[http://dx.doi.org/10.2106/00004623-198971080-00006] [PMID: 2777842]
[124]
York JE, Berk RH, Fuller GN, et al. Chondrosarcoma of the spine: 1954 to 1997. J Neurosurg 1999; 90(Suppl. 1): 73-8.
[PMID: 10413129]
[125]
Strike SA, McCarthy EF. Chondrosarcoma of the spine: a series of 16 cases and a review of the literature. Iowa Orthop J 2011; 31: 154-9.
[PMID: 22096435]
[126]
Lloret I, Server A, Bjerkehagen B. Primary spinal chondrosarcoma: radiologic findings with pathologic correlation. Acta Radiol 2006; 47(1): 77-84.
[http://dx.doi.org/10.1080/02841850500406852] [PMID: 16498937]
[127]
Hirsh LF, Thanki A, Spector HB. Primary spinal chondrosarcoma with eighteen-year follow-up: case report and literature review. Neurosurgery 1984; 14(6): 747-9.
[http://dx.doi.org/10.1227/00006123-198406000-00019] [PMID: 6462413]
[128]
Mattke M, Vogt K, Bougatf N, et al. High control rates of proton- and carbon-ion-beam treatment with intensity-modulated active raster scanning in 101 patients with skull base chondrosarcoma at the Heidelberg Ion Beam Therapy Center. Cancer 2018; 124(9): 2036-44.
[http://dx.doi.org/10.1002/cncr.31298] [PMID: 29469932]
[129]
Leeson MC, Makley JT, Carter JR. Metastatic skeletal disease in the pediatric population. J Pediatr Orthop 1985; 5(3): 261-7.
[http://dx.doi.org/10.1097/01241398-198505000-00001] [PMID: 2987304]
[130]
Venkateswaran L, Rodriguez-Galindo C, Merchant TE, Poquette CA, Rao BN, Pappo AS. Primary Ewing tumor of the vertebrae: clinical characteristics, prognostic factors, and outcome. Med Pediatr Oncol 2001; 37(1): 30-5.
[http://dx.doi.org/10.1002/mpo.1159] [PMID: 11466720]
[131]
Whitehouse GH, Griffiths GJ. Roentgenologic aspects of spinal involvement by primary and metastatic Ewing’s tumor. J Can Assoc Radiol 1976; 27(4): 290-7.
[PMID: 993244]
[132]
Ilaslan H, Sundaram M, Unni KK, Shives TC. Primary vertebral osteosarcoma: imaging findings. Radiology 2004; 230(3): 697-702.
[http://dx.doi.org/10.1148/radiol.2303030226] [PMID: 14749514]
[133]
Barwick KW, Huvos AG, Smith J. Primary osteogenic sarcoma of the vertebral column: a clinicopathologic correlation of ten patients. Cancer 1980; 46(3): 595-604.
[http://dx.doi.org/10.1002/1097-0142(19800801)46:3<595::AID-CNCR2820460328>3.0.CO;2-8] [PMID: 6930985]
[134]
Arndt CA, Crist WM. Common musculoskeletal tumors of childhood and adolescence. N Engl J Med 1999; 341(5): 342-52.
[http://dx.doi.org/10.1056/NEJM199907293410507] [PMID: 10423470]
[135]
Schoenfeld AJ, Hornicek FJ, Pedlow FX, et al. Osteosarcoma of the spine: experience in 26 patients treated at the Massachusetts General Hospital. Spine J 2010; 10(8): 708-14.
[http://dx.doi.org/10.1016/j.spinee.2010.05.017] [PMID: 20650409]
[136]
Mohamad O, Imai R, Kamada T, Nitta Y, Araki N. Working Group for Bone and Soft Tissue Sarcoma. Carbon ion radiotherapy for inoperable pediatric osteosarcoma. Oncotarget 2018; 9(33): 22976-85.
[http://dx.doi.org/10.18632/oncotarget.25165] [PMID: 29796166]
[137]
Mahnken AH, Wildberger JE, Gehbauer G, et al. Multidetector CT of the spine in multiple myeloma: comparison with MR imaging and radiography. AJR Am J Roentgenol 2002; 178(6): 1429-36.
[http://dx.doi.org/10.2214/ajr.178.6.1781429] [PMID: 12034612]
[138]
Wald JT. Imaging of spine neoplasm. Radiol Clin North Am 2012; 50(4): 749-76.
[http://dx.doi.org/10.1016/j.rcl.2012.04.002] [PMID: 22643394]
[139]
Jadvar H, Conti PS. Diagnostic utility of FDG PET in multiple myeloma. Skeletal Radiol 2002; 31(12): 690-4.
[http://dx.doi.org/10.1007/s00256-002-0580-2] [PMID: 12483429]
[140]
Mele A, Offidani M, Visani G, et al. Technetium-99m sestamibi scintigraphy is sensitive and specific for the staging and the follow-up of patients with multiple myeloma: a multicentre study on 397 scans. Br J Haematol 2007; 136(5): 729-35.
[http://dx.doi.org/10.1111/j.1365-2141.2006.06489.x] [PMID: 17233770]
[141]
Layton KF, Thielen KR, Cloft HJ, Kallmes DF. Acute vertebral compression fractures in patients with multiple myeloma: evaluation of vertebral body edema patterns on MR imaging and the implications for vertebroplasty. AJNR Am J Neuroradiol 2006; 27(8): 1732-4.
[PMID: 16971624]
[142]
Lecouvet FE, Vande Berg BC, Maldague BE, et al. Vertebral compression fractures in multiple myeloma. Part I. Distribution and appearance at MR imaging. Radiology 1997; 204(1): 195-9.
[http://dx.doi.org/10.1148/radiology.204.1.9205246] [PMID: 9205246]
[143]
Wallington M, Mendis S, Premawardhana U, Sanders P, Shahsavar-Haghighi K. Local control and survival in spinal cord compression from lymphoma and myeloma. Radiother Oncol 1997; 42(1): 43-7.
[http://dx.doi.org/10.1016/S0167-8140(96)01858-0] [PMID: 9132825]
[144]
Putz C, Wiedenhöfer B, Gerner HJ, Fürstenberg CH. Tokuhashi prognosis score: an important tool in prediction of the neurological outcome in metastatic spinal cord compression: a retrospective clinical study. Spine 2008; 33(24): 2669-74.
[http://dx.doi.org/10.1097/BRS.0b013e318188b98f] [PMID: 18981960]
[145]
Gokaraju K, Butler JS, Benton A, Suarez-Huerta ML, Selvadurai S, Molloy S. Multiple myeloma presenting with acute bony spinal cord compression and mechanical instability successfully managed nonoperatively. Spine J 2016; 16(8): e567-70.
[http://dx.doi.org/10.1016/j.spinee.2016.03.011] [PMID: 26997111]
[146]
Malhotra K, Lui DF, Butler JS, Selvadurai S, Molloy S. Successful nonsurgical treatment for highly unstable fracture subluxation of the spine secondary to myeloma. Spine J 2016; 16(8): e547-51.
[http://dx.doi.org/10.1016/j.spinee.2016.03.008] [PMID: 26970602]
[147]
Cawley DT, Butler JS, Benton A, et al. Managing the cervical spine in multiple myeloma patients. Hematol Oncol 2019; 37(2): 129-35.
[http://dx.doi.org/10.1002/hon.2564] [PMID: 30334279]
[148]
Patnaik S, Jyotsnarani Y, Uppin SG, Susarla R. Imaging features of primary tumors of the spine: A pictorial essay. Indian J Radiol Imaging 2016; 26(2): 279-89.
[http://dx.doi.org/10.4103/0971-3026.184413] [PMID: 27413280]
[149]
Mulligan ME, McRae GA, Murphey MD. Imaging features of primary lymphoma of bone. AJR Am J Roentgenol 1999; 173(6): 1691-7.
[http://dx.doi.org/10.2214/ajr.173.6.10584821] [PMID: 10584821]
[150]
Han S, Yang X, Jiang D, et al. Surgical outcomes and prognostic factors in patients with diffuse large B-cell lymphoma-associated metastatic spinal cord compression. Spine 2016; 41(15): E943-8.
[http://dx.doi.org/10.1097/BRS.0000000000001511] [PMID: 26890958]
[151]
Smith JK, Lury K, Castillo M. Imaging of spinal and spinal cord tumors. Semin Roentgenol 2006; 41(4): 274-93.
[http://dx.doi.org/10.1053/j.ro.2006.07.002] [PMID: 17010691]
[152]
Perrin RG, Laxton AW. Metastatic spine disease: epidemiology, pathophysiology, and evaluation of patients. Neurosurg Clin N Am 2004; 15(4): 365-73.
[http://dx.doi.org/10.1016/j.nec.2004.04.018] [PMID: 15450871]
[153]
Constans JP, de Divitiis E, Donzelli R, Spaziante R, Meder JF, Haye C. Spinal metastases with neurological manifestations. Review of 600 cases. J Neurosurg 1983; 59(1): 111-8.
[http://dx.doi.org/10.3171/jns.1983.59.1.0111] [PMID: 6864265]
[154]
Salvo N, Christakis M, Rubenstein J, et al. The role of plain radiographs in management of bone metastases. J Palliat Med 2009; 12(2): 195-8.
[http://dx.doi.org/10.1089/jpm.2008.0055] [PMID: 19207068]
[155]
Hamaoka T, Madewell JE, Podoloff DA, Hortobagyi GN, Ueno NT. Bone imaging in metastatic breast cancer. J Clin Oncol 2004; 22(14): 2942-53.
[http://dx.doi.org/10.1200/JCO.2004.08.181] [PMID: 15254062]
[156]
Yang H-L, Liu T, Wang X-M, Xu Y, Deng S-M. Diagnosis of bone metastases: a meta-analysis comparing ¹-FDG PET, CT, MRI and bone scintigraphy. Eur Radiol 2011; 21(12): 2604-17.
[http://dx.doi.org/10.1007/s00330-011-2221-4] [PMID: 21887484]
[157]
Heindel W, Gübitz R, Vieth V, Weckesser M, Schober O, Schäfers M. The diagnostic imaging of bone metastases. Dtsch Arztebl Int 2014; 111(44): 741-7.
[PMID: 25412631]
[158]
Jehn CF, Diel IJ, Overkamp F, et al. Management of metastatic bone disease algorithms for diagnostics and treatment. Anticancer Res 2016; 36(6): 2631-7.
[PMID: 27272771]
[159]
Duo J, Han X, Zhang L, Wang G, Ma Y, Yang Y. Comparison of FDG PET/CT and gadolinium-enhanced MRI for the detection of bone metastases in patients with cancer: a meta-analysis. Clin Nucl Med 2013; 38(5): 343-8.
[http://dx.doi.org/10.1097/RLU.0b013e3182817af3] [PMID: 23531774]
[160]
Beheshti M, Vali R, Waldenberger P, et al. The use of F-18 choline PET in the assessment of bone metastases in prostate cancer: correlation with morphological changes on CT. Mol Imaging Biol 2010; 12(1): 98-107.
[http://dx.doi.org/10.1007/s11307-009-0239-7] [PMID: 19588206]
[161]
Peterson JJ, Kransdorf MJ, O’Connor MI. Diagnosis of occult bone metastases: positron emission tomography. Clin Orthop Relat Res 2003; (415): S120-8.
[http://dx.doi.org/10.1097/01.blo.0000093051.96273.7c] [PMID: 14600601]
[162]
Shen G, Deng H, Hu S, Jia Z. Comparison of choline-PET/CT, MRI, SPECT, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a meta-analysis. Skeletal Radiol 2014; 43(11): 1503-13.
[http://dx.doi.org/10.1007/s00256-014-1903-9] [PMID: 24841276]
[163]
Chakraborty D, Bhattacharya A, Mete UK, Mittal BR. Comparison of 18F fluoride PET/CT and 99mTc-MDP bone scan in the detection of skeletal metastases in urinary bladder carcinoma. Clin Nucl Med 2013; 38(8): 616-21.
[http://dx.doi.org/10.1097/RLU.0b013e31828da5cc] [PMID: 23603596]
[164]
Han LJ, Au-Yong TK, Tong WC, Chu KS, Szeto LT, Wong CP. Comparison of bone single-photon emission tomography and planar imaging in the detection of vertebral metastases in patients with back pain. Eur J Nucl Med 1998; 25(6): 635-8.
[http://dx.doi.org/10.1007/s002590050266] [PMID: 9618579]
[165]
Kitajima K, Suenaga Y, Ueno Y, et al. Value of fusion of PET and MRI in the detection of intra-pelvic recurrence of gynecological tumor: comparison with 18F-FDG contrast-enhanced PET/CT and pelvic MRI. Ann Nucl Med 2014; 28(1): 25-32.
[http://dx.doi.org/10.1007/s12149-013-0777-6] [PMID: 24129541]
[166]
Catalano OA, Rosen BR, Sahani DV, et al. Clinical impact of PET/MR imaging in patients with cancer undergoing same-day PET/CT: initial experience in 134 patients- a hypothesis-generating exploratory study. Radiology 2013; 269(3): 857-69.
[http://dx.doi.org/10.1148/radiol.13131306] [PMID: 24009348]
[167]
Fisher CG, DiPaola CP, Ryken TC, et al. A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group. Spine 2010; 35(22): E1221-9.
[http://dx.doi.org/10.1097/BRS.0b013e3181e16ae2] [PMID: 20562730]
[168]
Bollen L, Dijkstra SPD, Bartels RHMA, et al. Clinical management of spinal metastases-The Dutch national guideline. Eur J Cancer 2018; 104: 81-90.
[http://dx.doi.org/10.1016/j.ejca.2018.08.028] [PMID: 30336360]
[169]
Avrahami E, Tadmor R, Dally O, Hadar H. Early MR demonstration of spinal metastases in patients with normal radiographs and CT and radionuclide bone scans. J Comput Assist Tomogr 1989; 13(4): 598-602.
[http://dx.doi.org/10.1097/00004728-198907000-00008] [PMID: 2745777]
[170]
Algra PR, Bloem JL, Tissing H, Falke TH, Arndt JW, Verboom LJ. Detection of vertebral metastases: comparison between MR imaging and bone scintigraphy. Radiographics 1991; 11(2): 219-32.
[http://dx.doi.org/10.1148/radiographics.11.2.2028061] [PMID: 2028061]
[171]
Smoker WR, Godersky JC, Knutzon RK, Keyes WD, Norman D, Bergman W. The role of MR imaging in evaluating metastatic spinal disease. AJR Am J Roentgenol 1987; 149(6): 1241-8.
[http://dx.doi.org/10.2214/ajr.149.6.1241] [PMID: 3500616]
[172]
Algra PR, Heimans JJ, Valk J, Nauta JJ, Lachniet M, Van Kooten B. Do metastases in vertebrae begin in the body or the pedicles? Imaging study in 45 patients. AJR Am J Roentgenol 1992; 158(6): 1275-9.
[http://dx.doi.org/10.2214/ajr.158.6.1590123] [PMID: 1590123]
[173]
Schmidt GP, Schoenberg SO, Reiser MF, Baur-Melnyk A. Whole-body MR imaging of bone marrow. Eur J Radiol 2005; 55(1): 33-40.
[http://dx.doi.org/10.1016/j.ejrad.2005.01.019] [PMID: 15950099]
[174]
Ciray I, Lindman H, Aström GKO, Wanders A, Bergh J, Ahlström HK. Effect of granulocyte colony-stimulating factor (G-CSF)-supported chemotherapy on MR imaging of normal red bone marrow in breast cancer patients with focal bone metastases. Acta Radiol 2003; 44(5): 472-84.
[http://dx.doi.org/10.1080/j.1600-0455.2003.00123.x] [PMID: 14510752]
[175]
Kim JK, Learch TJ, Colletti PM, Lee JW, Tran SD, Terk MR. Diagnosis of vertebral metastasis, epidural metastasis, and malignant spinal cord compression: are T(1)-weighted sagittal images sufficient? Magn Reson Imaging 2000; 18(7): 819-24.
[http://dx.doi.org/10.1016/S0730-725X(00)00181-8] [PMID: 11027875]
[176]
Bilsky MH, Laufer I, Fourney DR, et al. Reliability analysis of the epidural spinal cord compression scale. J Neurosurg Spine 2010; 13(3): 324-8.
[http://dx.doi.org/10.3171/2010.3.SPINE09459] [PMID: 20809724]
[177]
Rades D, Rudat V, Veninga T, et al. A score predicting posttreatment ambulatory status in patients irradiated for metastatic spinal cord compression. Int J Radiat Oncol Biol Phys 2008; 72(3): 905-8.
[http://dx.doi.org/10.1016/j.ijrobp.2008.02.018] [PMID: 18436390]
[178]
Rades D, Douglas S, Huttenlocher S, et al. Validation of a score predicting post-treatment ambulatory status after radiotherapy for metastatic spinal cord compression. Int J Radiat Oncol Biol Phys 2011; 79(5): 1503-6.
[http://dx.doi.org/10.1016/j.ijrobp.2010.01.024] [PMID: 20605351]
[179]
Takagi T, Katagiri H, Kim Y, et al. Skeletal metastasis of unknown primary origin at the initial visit: A retrospective analysis of 286 cases. PLoS One 2015; 10(6): e0129428.
[http://dx.doi.org/10.1371/journal.pone.0129428] [PMID: 26115010]
[180]
Mauch JT, Carr CM, Cloft H, Diehn FE. Review of the imaging features of benign osteoporotic and malignant vertebral compression fractures. AJNR Am J Neuroradiol 2018; 39(9): 1584-92.
[http://dx.doi.org/10.3174/ajnr.A5528] [PMID: 29348133]
[181]
Schwaiger BJ, Gersing AS, Baum T, Krestan CR, Kirschke JS. Distinguishing benign and malignant vertebral fractures using CT and MRI. Semin Musculoskelet Radiol 2016; 20(4): 345-52.
[http://dx.doi.org/10.1055/s-0036-1592433] [PMID: 27842427]
[182]
Kim DH, Yoo HJ, Hong SH, Choi J-Y, Chae HD, Chung BM. Differentiation of Acute Osteoporotic and Malignant Vertebral Fractures by Quantification of Fat Fraction With a Dixon MRI Sequence. AJR Am J Roentgenol 2017; 209(6): 1331-9.
[http://dx.doi.org/10.2214/AJR.17.18168] [PMID: 28858543]
[183]
Pearce T, Philip S, Brown J, Koh DM, Burn PR. Bone metastases from prostate, breast and multiple myeloma: differences in lesion conspicuity at short-tau inversion recovery and diffusion-weighted MRI. Br J Radiol 2012; 85(1016): 1102-6.
[http://dx.doi.org/10.1259/bjr/30649204] [PMID: 22457319]
[184]
Cuénod CA, Laredo JD, Chevret S, et al. Acute vertebral collapse due to osteoporosis or malignancy: appearance on unenhanced and gadolinium-enhanced MR images. Radiology 1996; 199(2): 541-9.
[http://dx.doi.org/10.1148/radiology.199.2.8668809] [PMID: 8668809]
[185]
Kubota T, Yamada K, Ito H, Kizu O, Nishimura T. High-resolution imaging of the spine using multidetector-row computed tomography: differentiation between benign and malignant vertebral compression fractures. J Comput Assist Tomogr 2005; 29(5): 712-9.
[http://dx.doi.org/10.1097/01.rct.0000175500.41836.24] [PMID: 16163049]
[186]
Laredo JD, Lakhdari K, Bellaïche L, Hamze B, Janklewicz P, Tubiana JM. Acute vertebral collapse: CT findings in benign and malignant nontraumatic cases. Radiology 1995; 194(1): 41-8.
[http://dx.doi.org/10.1148/radiology.194.1.7997579] [PMID: 7997579]
[187]
Baur-Melnyk A. Malignant versus benign vertebral collapse: are new imaging techniques useful? Cancer Imaging 2009 Oct; 9(Spec No A): S49-S51..
[http://dx.doi.org/10.1102/1470-7330.2009.9013]
[188]
Cho W-I, Chang U-K. Comparison of MR imaging and FDG-PET/CT in the differential diagnosis of benign and malignant vertebral compression fractures. J Neurosurg Spine 2011; 14(2): 177-83.
[http://dx.doi.org/10.3171/2010.10.SPINE10175] [PMID: 21214309]
[189]
Laufer I, Rubin DG, Lis E, et al. The NOMS framework: approach to the treatment of spinal metastatic tumors. Oncologist 2013; 18(6): 744-51.
[http://dx.doi.org/10.1634/theoncologist.2012-0293] [PMID: 23709750]
[190]
Matamalas A, Valverde C, Benavente S, et al. Team approach: Metastatic disease of the spine. JBJS Rev 2018; 6(5): e6.
[http://dx.doi.org/10.2106/JBJS.RVW.17.00118] [PMID: 29762343]
[191]
Quraishi NA, Arealis G, Salem KMI, Purushothamdas S, Edwards KL, Boszczyk BM. The surgical management of metastatic spinal tumors based on an Epidural Spinal Cord Compression (ESCC) scale. Spine J 2015; 15(8): 1738-43.
[http://dx.doi.org/10.1016/j.spinee.2015.03.040] [PMID: 25817737]
[192]
Spratt DE, Beeler WH, de Moraes FY, et al. An integrated multidisciplinary algorithm for the management of spinal metastases: an International Spine Oncology Consortium report. Lancet Oncol 2017; 18(12): e720-30.
[http://dx.doi.org/10.1016/S1470-2045(17)30612-5] [PMID: 29208438]
[193]
Thibault I, Al-Omair A, Masucci GL, et al. Spine stereotactic body radiotherapy for renal cell cancer spinal metastases: analysis of outcomes and risk of vertebral compression fracture. J Neurosurg Spine 2014; 21(5): 711-8.
[http://dx.doi.org/10.3171/2014.7.SPINE13895] [PMID: 25170656]
[194]
Sohn S, Chung CK, Sohn MJ, et al. Stereotactic radiosurgery compared with external radiation therapy as a primary treatment in spine metastasis from renal cell carcinoma: a multicenter, matched-pair study. J Neurooncol 2014; 119(1): 121-8.
[http://dx.doi.org/10.1007/s11060-014-1455-9] [PMID: 24792488]
[195]
Folkert MR, Bilsky MH, Tom AK, et al. Outcomes and toxicity for hypofractionated and single-fraction image-guided stereotactic radiosurgery for sarcomas metastasizing to the spine. Int J Radiat Oncol Biol Phys 2014; 88(5): 1085-91.
[http://dx.doi.org/10.1016/j.ijrobp.2013.12.042] [PMID: 24661662]
[196]
Weber MH, Burch S, Buckley J, et al. Instability and impending instability of the thoracolumbar spine in patients with spinal metastases: a systematic review. Int J Oncol 2011; 38(1): 5-12.
[PMID: 21109920]
[197]
Fourney DR, Frangou EM, Ryken TC, et al. Spinal instability neoplastic score: an analysis of reliability and validity from the spine oncology study group. J Clin Oncol 2011; 29(22): 3072-7.
[http://dx.doi.org/10.1200/JCO.2010.34.3897] [PMID: 21709187]
[198]
Fox S, Spiess M, Hnenny L, Fourney DR. Spinal instability neoplastic score (sins): reliability among spine fellows and resident physicians in orthopedic surgery and neurosurgery. Global Spine J 2017; 7(8): 744-8.
[http://dx.doi.org/10.1177/2192568217697691] [PMID: 29238637]
[199]
Campos M, Urrutia J, Zamora T, et al. The spine instability neoplastic score: an independent reliability and reproducibility analysis. Spine J 2014; 14(8): 1466-9.
[http://dx.doi.org/10.1016/j.spinee.2013.08.044] [PMID: 24275615]
[200]
Fisher CG, Schouten R, Versteeg AL, et al. Reliability of the Spinal Instability Neoplastic Score (SINS) among radiation oncologists: an assessment of instability secondary to spinal metastases. Radiat Oncol 2014; 9: 69.
[http://dx.doi.org/10.1186/1748-717X-9-69] [PMID: 24594004]
[201]
Fisher CG, Versteeg AL, Schouten R, et al. Reliability of the spinal instability neoplastic scale among radiologists: an assessment of instability secondary to spinal metastases. AJR Am J Roentgenol 2014; 203(4): 869-74.
[http://dx.doi.org/10.2214/AJR.13.12269] [PMID: 25247954]
[202]
Versteeg AL, Verlaan J-J, Sahgal A, et al. The spinal instability neoplastic score: impact on oncologic decision-making. Spine 2016; 41(Suppl. 20): S231-7.
[http://dx.doi.org/10.1097/BRS.0000000000001822] [PMID: 27488297]
[203]
Arana E, Kovacs FM, Royuela A, Asenjo B, Pérez-Ramírez Ú, Zamora J. Spanish Back Pain Research Network Task Force for the Improvement of Inter-Disciplinary Management of Spinal Metastasis. Spine Instability Neoplastic Score: agreement across different medical and surgical specialties. Spine J 2016; 16(5): 591-9.
[http://dx.doi.org/10.1016/j.spinee.2015.10.006] [PMID: 26471708]
[204]
Leone A, Cianfoni A, Zecchi V, Cortese MC, Rumi N, Colosimo C. Instability and impending instability in patients with vertebral metastatic disease. Skeletal Radiol 2019; 48(2): 195-207.
[http://dx.doi.org/10.1007/s00256-018-3032-3] [PMID: 30069584]
[205]
Fourney DR, Schomer DF, Nader R, et al. Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients. J Neurosurg 2003; 98(Suppl. 1): 21-30.
[PMID: 12546384]
[206]
Dickman CA, Fehlings MG, Gokaslan ZL. Spinal cord and spinal column tumors: Principles and practice. AJNR Am J Neuroradiol 2007; 28(2): 394-5.
[207]
Ishida Y, Shigematsu H, Tsukamoto S, et al. Impairment-driven cancer rehabilitation in patients with neoplastic spinal cord compression using minimally invasive spine stabilization. World J Surg Oncol 2020; 18(1): 187.
[http://dx.doi.org/10.1186/s12957-020-01964-y] [PMID: 32711537]
[208]
Thibault I, Chang EL, Sheehan J, et al. Response assessment after stereotactic body radiotherapy for spinal metastasis: a report from the SPIne response assessment in Neuro-Oncology (SPINO) group. Lancet Oncol 2015; 16(16): e595-603.
[http://dx.doi.org/10.1016/S1470-2045(15)00166-7] [PMID: 26678212]
[209]
Gwak H-S, Youn S-M, Chang U, et al. Usefulness of (18)F-fluorodeoxyglucose PET for radiosurgery planning and response monitoring in patients with recurrent spinal metastasis. Minim Invasive Neurosurg 2006; 49(3): 127-34.
[http://dx.doi.org/10.1055/s-2006-932181] [PMID: 16921451]
[210]
Al-Omair A, Smith R, Kiehl T-R, et al. Radiation-induced vertebral compression fracture following spine stereotactic radiosurgery: clinicopathological correlation. J Neurosurg Spine 2013; 18(5): 430-5.
[http://dx.doi.org/10.3171/2013.2.SPINE12739] [PMID: 23495889]
[211]
Taylor DR, Weaver JA. Tumor pseudoprogression of spinal metastasis after radiosurgery: a novel concept and case reports. J Neurosurg Spine 2015; 22(5): 534-9.
[http://dx.doi.org/10.3171/2014.10.SPINE14444] [PMID: 25658469]
[212]
Sahgal A, Atenafu EG, Chao S, et al. Vertebral compression fracture after spine stereotactic body radiotherapy: a multi-institutional analysis with a focus on radiation dose and the spinal instability neoplastic score. J Clin Oncol 2013; 31(27): 3426-31.
[http://dx.doi.org/10.1200/JCO.2013.50.1411] [PMID: 23960179]
[213]
Behzadi AH, Raza SI, Carrino JA, et al. Applications of PET/CT and PET/MR imaging in primary bone malignancies. PET Clin 2018; 13(4): 623-34.
[http://dx.doi.org/10.1016/j.cpet.2018.05.012] [PMID: 30219192]
[214]
Shiga NT, Del Grande F, Lardo O, Fayad LM. Imaging of primary bone tumors: determination of tumor extent by non-contrast sequences. Pediatr Radiol 2013; 43(8): 1017-23.
[http://dx.doi.org/10.1007/s00247-012-2605-x] [PMID: 23341088]
[215]
Kenneally BE, Gutowski CJ, Reynolds AW, Morrison WB, Abraham JA. Utility of opposed-phase magnetic resonance imaging in differentiating sarcoma from benign bone lesions. J Bone Oncol 2015; 4(4): 110-4.
[http://dx.doi.org/10.1016/j.jbo.2015.10.001] [PMID: 26730359]

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