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Current Rheumatology Reviews

Editor-in-Chief

ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

Research Article

No Association of MicroRNA-146a rs2910164 Polymorphism and Risk of Primary Gout Development in Chinese Han Populations: A Case-control Study

Author(s): Yu-Feng Qing*, Quan-Bo Zhang, Fei Dai, Yu-Qin Huang, Jian-Xiong Zheng, Yi-Ping Tang, Zeng-Rong Dong and Shun-Bing Wang

Volume 17, Issue 4, 2021

Published on: 26 July, 2021

Page: [373 - 378] Pages: 6

DOI: 10.2174/1573397117666210726125632

Price: $65

Abstract

Background: Previous studies demonstrated that MicroRNA-146a (miR-146a) plays an important role in the regulation of autoinflammatory diseases including primary gout. The G/C polymorphism (rs2910164) in the precursor sequence of miR-146a caused its stem region to change from G: U to C: U,which can contribute to the susceptibility of human diseases. However, no genetic relevance studies of miR-146a gene polymorphisms to gout have been reported by now.

Objective: The purpose of this study was to analyze the association between the miR-146a rs2910164 genetic polymorphism and the susceptibility of the Chinese Han population to primary gout.

Methods: 1130 Chinese Han participants (including 606 primary gout patients and 524 gender and age-matched healthy control subjects) were recruited and the 5'exonuclease TaqMan® technology was used to perform miR-146a rs2910164 genotyping.

Results: After statistical analysis, no significant differences were observed between gout patients and healthy controls in genotype and allele frequency.

Conclusion: Our results indicate that there is no evidence for the involvement of the miR-146a rs2910164 polymorphisms in susceptibility to primary gout in the Chinese Han population.

Keywords: miR-146a, rs2910164, polymorphisms, gout, susceptibility, hyperuricemia.


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