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Medicinal Chemistry

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ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Review Article

Anti-infective Potential of Manzamine Alkaloids - A Review

Author(s): Penta Ashok, Faheem, Banoth K. Kumar, Subhash Chander, Kondapalli Venkata Gowri Chandra Sekhar and Murugesan Sankaranarayanan*

Volume 18, Issue 6, 2022

Published on: 05 January, 2022

Page: [629 - 654] Pages: 26

DOI: 10.2174/1573406417666210803101740

Price: $65

Abstract

Background: From time immemorial, natural products have been used for the treatment of various diseases. Various natural products, their semisynthetic derivatives, and synthetic analogs have been explored for their anti-infective properties. One such group of natural compounds that has been widely explored is manzamine alkaloids. Manzamine alkaloids are complex natural compounds consisting of a β-carboline nucleus attached to a pentacyclic ring system; they were first isolated from a marine sponge during the 1980s.

Objective: This review aims to provide a critical overview on the anti-infective potential of manzamine alkaloids.

Methods: A comprehensive and exhaustive review of the literature on manzamine alkaloids, and their isolation, anti-infective properties, and mechanism of action, is presented.

Results: Various manzamine alkaloids have been isolated and have been found to exhibit potent antiinfective activities like antibacterial, antimalarial, antiviral, antifungal, antileishmanial, among others. These manzamine alkaloids exhibit their anti-infective activity by inhibiting targets like GSK-3β, MtSK.

Conclusion: This present review along with structure-activity relationship study of manzamine alkaloids for their anti-infective activity will be useful for further development of semisynthetic manzamine analogs as potent anti-infective agents with better therapeutic potential and reduced toxicity.

Keywords: Manzamine, carboline, malaria, leishmaniasis, tuberculosis, human immunodeficiency virus, bacteria, fungi.

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Graphical Abstract
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