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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Transdermal Delivery of Macromolecules Using Nano Lipid Carriers

Author(s): Sana Kalave, Bappaditya Chatterjee*, Parth Shah and Ambikanandan Misra

Volume 27, Issue 42, 2021

Published on: 20 August, 2021

Page: [4330 - 4340] Pages: 11

DOI: 10.2174/1381612827666210820095330

Price: $65

Abstract

Skin being the largest external organ, offers an appealing procedure for transdermal drug delivery, so the drug needs to reach above the outermost layer of the skin, i.e., stratum corneum. Small molecular drug entities obeying the Lipinski rule, i.e., drugs having a molecular weight less than 500 Da, high lipophilicity, and optimum polarity, are favored enough to be used on the skin as therapeutics. Skin's barrier properties prevent the transport of macromolecules at pre-determined therapeutic rates. Notable advancements in macromolecules' transdermal delivery have occurred in recent years. Scientists have opted for liposomes, the use of electroporation, low-frequency ultrasound techniques, etc. Some of these have shown better delivery of macromolecules at clinically beneficial rates. These physical technologies involve complex mechanisms, which may irreversibly incur skin damage. Majorly, two types of lipid-based formulations, including Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs), are widely investigated as transdermal delivery systems. In this review, the concepts, mechanisms, and applications of nanostructured lipid carriers used to transport macromolecules via transdermal routes are thoroughly reviewed and presented along with their clinical perspective.

Keywords: Nanostructured Lipid Carriers (NLCs), penetration enhancers, microfabricated needles, follicular delivery, laser ablation, cutaneous delivery, macromolecule.


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