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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

General Review Article

Essential Oils as Alternative Promising Anti-Candidal Agents: Progress and Prospects

Author(s): Awad Shala, Shweta Singh, Saif Hameed* and S.M. Paul Khurana

Volume 28, Issue 1, 2022

Published on: 30 November, 2021

Page: [58 - 70] Pages: 13

DOI: 10.2174/1381612827666210914124344

Price: $65


Candida albicans is one of the main agents responsible for opportunistic pathogenic infections. The progressive emergence of fungal resistance to conventional antibiotics and its side effects, as well as treatment costs, are considered major limitations for antifungal drugs. It has drawn scientists' attention to the search for potential substitution and reliable therapeutic alternatives for the antifungal compounds from sources like medicinal plants, which contain numerous bioactive compounds such as essential oils. Essential oils (EO), apart from having lower toxicity and better biodegradability, are eco-friendly in nature as compared with conventional antibiotics. Furthermore, extracted essential oils have been reported to possess potent antimicrobial, antiinflammatory, and antioxidant properties that nominate them as promising natural candidates to combat numerous fungal ailments. Thus, the determination of antifungal efficacy of essential oil-bearing plants on Candida spp. will provide miscellaneous knowledge for future clinical studies that are required for the development of new formulations as alternative therapeutic agents to control the growth of Candida species. Therefore, this review summarizes the gist of major essential oils that have been investigated for their anti- Candida potential with some recommendations for further study.

Keywords: Antifungal activity, essential oils, antiCandida, biofilm, cell membrane, cell wall, mass spectrometry, cytotoxicity.

Karpiński TM. Essential oils of lamiaceae family plants as antifungals. Biomolecules 2020; 10(1): 103.
[] [PMID: 31936168]
Elewski BE. Onychomycosis: pathogenesis, diagnosis, and management. Clin Microbiol Rev 1998; 11(3): 415-29.
[] [PMID: 9665975]
Hamad M, Kazandji N, Awadallah S, Allam H. Prevalence and epidemiological characteristics of vaginal candidiasis in the UAE. Mycoses 2014; 57(3): 184-90.
[] [PMID: 24102778]
Schulze J, Sonnenborn U. Yeasts in the gut: from commensals to infectious agents. Dtsch Arztebl Int 2009; 106(51-52): 837-42.
[PMID: 20062581]
Martins N, Barros L, Santos-Buelga C, Henriques M, Silva S, Ferreira ICFR. Evaluation of bioactive properties and phenolic compounds in different extracts prepared from Salvia officinalis L. Food Chem 2015; 170: 378-85.
[] [PMID: 25306360]
Kathuria S, Singh PK, Sharma C, et al. Multidrug-resistant Candida auris misidentified as Candida haemulonii: characterization by matrix-assisted laser desorption ionization--time of flight mass spectrometry and DNA sequencing and its antifungal susceptibility profile variability by Vitek 2. J Clin Microbiol 2015; 53(6): 1823-30.
[] [PMID: 25809970]
Geffers C, Gastmeier P. Nosocomial infections and multidrug-resistant organisms in Germany: epidemiological data from KISS (the Hospital Infection Surveillance System). Dtsch Arztebl Int 2011; 108(6): 87-93.
[PMID: 21373275]
Sanglard D, Coste A, Ferrari S. Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation. FEMS Yeast Res 2009; 9(7): 1029-50.
[] [PMID: 19799636]
Vandeputte P, Ferrari S, Coste AT. Antifungal resistance and new strategies to control fungal infections. Int J Microbiol 2012.2012713687
[] [PMID: 22187560]
Lóránd T, Kocsis B. Recent advances in antifungal agents. Mini Rev Med Chem 2007; 7(9): 900-11.
[] [PMID: 17897080]
Sobel JD. Vulvovaginal candidosis. Lancet 2007; 369(9577): 1961-71.
[] [PMID: 17560449]
Beardsley J, Halliday CL, Chen SC, Sorrell TC. Responding to the emergence of antifungal drug resistance: perspectives from the bench and the bedside. Future Microbiol 2018; 13: 1175-91.
[] [PMID: 30113223]
Hurdle JG, O’Neill AJ, Chopra I, Lee RE. Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections. Nat Rev Microbiol 2011; 9(1): 62-75.
[] [PMID: 21164535]
Burt SA, Reinders RD. Antibacterial activity of selected plant essential oils against Escherichia coli O157:H7. Lett Appl Microbiol 2003; 36(3): 162-7.
[] [PMID: 12581376]
Khan A, Ahmad A, Akhtar F, et al. Ocimum sanctum essential oil and its active principles exert their antifungal activity by disrupting ergosterol biosynthesis and membrane integrity. Res Microbiol 2010; 161(10): 816-23.
[] [PMID: 20868749]
Naeini A, Naderi NJ, Shokri H. Analysis and in vitro anti-Candida antifungal activity of Cuminum cyminum and Salvadora persica herbs extracts against pathogenic Candida strains. J Mycol Med 2014; 24(1): 13-8.
[] [PMID: 24210587]
Silva F, Ferreira S, Duarte A, Mendonça DI, Domingues FC. Antifungal activity of Coriandrum sativum essential oil, its mode of action against Candida species and potential synergism with amphotericin B. Phytomedicine 2011; 19(1): 42-7.
[] [PMID: 21788125]
De Macêdo DG, Souza MMA, Morais-Braga MFB. Effect of seasonality on chemical profile and antifungal activity of essential oil isolated from leaves Psidium salutare (Kunth) O. Berg. Peer J 6: e5476..
Essid R, Hammami M, Gharbi D, et al. Antifungal mechanism of the combination of Cinnamomum verum and Pelargonium graveolens essential oils with fluconazole against pathogenic Candida strains. Appl Microbiol Biotechnol 2017; 101(18): 6993-7006.
[] [PMID: 28766033]
Gullo FP, Fusco-almeida AM, Mendes-giannini MJS. Essential oils and major compounds of Hedychium coronarium Koenig (Zingiberaceae) against pathogenic yeast of Candida and Cryptococcus genus. Rev Cienc Farm Basica Apl 2016; 37: 1-6.
Rathod T, Padalia H, Chanda S. Chemical constituents of Mentha piperita and Pongamia pinnata essential oils and their synergistic anticandidal activity with some antibiotics against multidrug resistant clinical isolates of Candida. J Pharmacogn Phytochem 2017; 6: 579-89.
Zore GB, Thakre AD, Rathod V, Karuppayil SM. Evaluation of anti-Candida potential of geranium oil constituents against clinical isolates of Candida albicans differentially sensitive to fluconazole: inhibition of growth, dimorphism and sensitization. Mycoses 2011; 54(4): e99-e109.
[] [PMID: 20337938]
Taweechaisupapong S, Aieamsaard J, Chitropas P, Khunkitti W. Inhibitory effect of lemongrass oil and its major constituents on Candida biofilm and germ tube formation. S Afr J Bot 2012; 81: 95-102.
Khan MSA, Ahmad I. Antibiofilm activity of certain phytocompounds and their synergy with fluconazole against Candida albicans biofilms. J Antimicrob Chemother 2012; 67(3): 618-21.
[] [PMID: 22167241]
Raut JS, Shinde RB, Chauhan NM, Karuppayil SM. Phenylpropanoids of plant origin as inhibitors of biofilm formation by Candida albicans. J Microbiol Biotechnol 2014; 24(9): 1216-25.
[] [PMID: 24851813]
Giongo JL, de Almeida Vaucher R, Fausto VP, et al. Anti-Candida activity assessment of Pelargonium graveolens oil free and nanoemulsion in biofilm formation in hospital medical supplies. Microb Pathog 2016; 100: 170-8.
[] [PMID: 27544324]
Souza CMC, Pereira Junior SA, Moraes Tda S, et al. Antifungal activity of plant-derived essential oils on Candida tropicalis planktonic and biofilms cells. Med Mycol 2016; 54(5): 515-23.
[] [PMID: 26868902]
Serra E, Hidalgo-Bastida LA, Verran J, Williams D, Malic S. Antifungal activity of commercial essential oils and biocides against Candida albicans. Pathogens 2018; 7(1): 15.
[] [PMID: 29370147]
Peixoto LR, Rosalen PL, Ferreira GLS, et al. Antifungal activity, mode of action and anti-biofilm effects of Laurus nobilis Linnaeus essential oil against Candida spp. Arch Oral Biol 2017; 73: 179-85.
[] [PMID: 27771586]
de Macêdo DG, Souza MMA, Morais-Braga MFB, et al. Effect of seasonality on chemical profile and antifungal activity of essential oil isolated from leaves Psidium salutare (Kunth) O Berg PeerJ 2018; 6e5476
[] [PMID: 30402343]
Farisa Banu S, Rubini D, Shanmugavelan P, et al. Effects of patchouli and cinnamon essential oils on biofilm and hyphae formation by Candida species. J Mycol Med 2018; 28(2): 332-9.
[] [PMID: 29571979]
Rajkowska K, Nowicka-Krawczyk P, Kunicka-Styczyńska A. Effect of clove and thyme essential oils on Candida biofilm formation and the oil distribution in yeast cells. Molecules 2019; 24(10): 1954.
[] [PMID: 31117281]
Dolatabadi S, Salari Z, Mahboubi M. Antifungal effects of Ziziphora tenuior, Lavandula angustifolia, Cuminum cyminum essential oils against clinical isolates of Candida albicans from women suffering from vulvovaginal candidiasis. Infectio 2019; 23: 222-6.
Venkata S, Zeeshan F, Kamal A, Luqman AK, Saif H. Efficiency of vanillin in impeding metabolic adaptability and virulence of Candida albicans by inhibiting glyoxylate cycle, morphogenesis, and biofilm formation. Curr Med Mycol 2020; 6(1): 1-8.
[PMID: 32420501]
Saville SP, Lazzell AL, Bryant AP, et al. Inhibition of filamentation can be used to treat disseminated candidiasis. Antimicrob Agents Chemother 2006; 50(10): 3312-6.
[] [PMID: 17005810]
Pina-Vaz C, Gonçalves Rodrigues A, Pinto E, et al. Antifungal activity of Thymus oils and their major compounds. J Eur Acad Dermatol Venereol 2004; 18(1): 73-8.
[] [PMID: 14678536]
Alviano WS, Mendonça-Filho RR, Alviano DS, et al. Antimicrobial activity of Croton cajucara Benth linalool-rich essential oil on artificial biofilms and planktonic microorganisms. Oral Microbiol Immunol 2005; 20(2): 101-5.
[] [PMID: 15720570]
Vale-Silva L, Silva MJ, Oliveira D, et al. Correlation of the chemical composition of essential oils from Origanum vulgare subsp. virens with their in vitro activity against pathogenic yeasts and filamentous fungi. J Med Microbiol 2012; 61(Pt 2): 252-60.
[] [PMID: 22016556]
Budzyńska A, Różalska S, Sadowska B, Różalska B. Candida albicans/Staphylococcus aureus Dual-Species biofilm as a target for the Combination of essential oils and fluconazole or mupirocin. Mycopathologia 2017; 182(11-12): 989-95.
[] [PMID: 28823093]
Hammer KA, Carson CF, Riley TV. Antifungal effects of Melaleuca alternifolia (tea tree) oil and its components on Candida albicans, Candida glabrata and Saccharomyces cerevisiae. J Antimicrob Chemother 2004; 53(6): 1081-5.
[] [PMID: 15140856]
Chen Y, Zeng H, Tian J, Ban X, Ma B, Wang Y. Antifungal mechanism of essential oil from Anethum graveolens seeds against Candida albicans. J Med Microbiol 2013; 62(Pt 8): 1175-83.
[] [PMID: 23657528]
Sánchez ME, Turina AV, García DA, Nolan MV, Perillo MA. Surface activity of thymol: implications for an eventual pharmacological activity. Colloids Surf B Biointerfaces 2004; 34(2): 77-86.
[] [PMID: 15261077]
Bona E, Cantamessa S, Pavan M, et al. Sensitivity of Candida albicans to essential oils: are they an alternative to antifungal agents? J Appl Microbiol 2016; 121(6): 1530-45.
[] [PMID: 27568869]
Rajkowska K, Nowak A, Kunicka-Styczyńska A, Siadura A. Biological effects of various chemically characterized essential oils: Investigation of the mode of action against: Candida albicans and HeLa cells. RSC Advances 2016; 6: 97199-207.
Saibabu V, Fatima Z, Ahmad K, Khan LA, Hameed S. Octyl gallate triggers dysfunctional mitochondria leading to ROS driven membrane damage and metabolic inflexibility along with attenuated virulence in Candida albicans. Med Mycol 2020; 58(3): 380-92.
[] [PMID: 31135913]
Benson JM, Nahata MC. Clinical use of systemic antifungal agents. Clin Pharm 1988; 7(6): 424-38.
[PMID: 3042267]
da Silva Dantas A, Patterson MJ, Smith DA, et al. Thioredoxin regulates multiple hydrogen peroxide-induced signaling pathways in Candida albicans. Mol Cell Biol 2010; 30(19): 4550-63.
[] [PMID: 20679492]
Miao H, Zhao L, Li C, et al. Inhibitory effect of Shikonin on Candida albicans growth. Biol Pharm Bull 2012; 35(11): 1956-63.
[] [PMID: 23123467]
Singh S, Fatima Z, Hameed S. Insights into the mode of action of anticandidal herbal monoterpenoid geraniol reveal disruption of multiple MDR mechanisms and virulence attributes in Candida albicans. Arch Microbiol 2016; 198(5): 459-72.
[] [PMID: 26935560]
Ansari MA, Fatima Z, Hameed S. Anticandidal effect and mechanisms of monoterpenoid, perillyl alcohol against Candida albicans. PLoS One 2016; 11(9)e0162465
[] [PMID: 27627759]
Cavalcanti YW, De Fátima D, De Almeida L, Padilha WWN. Anti-adherent activity of Rosmarinus officinalis essential oil on Candida albicans: An SEM analysis. Rev Odonto Ciênc 2011; 26: 139-44.
Soliman SSM, Alsaadi AI, Youssef EG, et al. Calli essential oils synergize with lawsone against multidrug resistant pathogens. Molecules 2017; 22(12): 2223.
[] [PMID: 29261103]
Satthanakul P, Taweechaisupapong S, Luengpailin S, Khunkitti W. The antifungal efficacy of essential oils in combination with chlorhexidine against Candida spp. Songklanakarin J Sci Technol 2019; 41: 144-50.
Freire JCP, Júnior JKDO, Silva DDF, et al. Antifungal activity of essential oils against Candida albicans strains isolated from users of dental prostheses. Evidence-based Complement Altern Med 2017.
Campbell BC, Chan KL, Kim JH. Chemosensitization as a means to augment commercial antifungal agents. Front Microbiol 2012; 3: 79.
[] [PMID: 22393330]
Pinto E, Pina-Vaz C, Salgueiro L, et al. Antifungal activity of the essential oil of Thymus pulegioides on Candida, Aspergillus and dermatophyte species. J Med Microbiol 2006; 55(Pt 10): 1367-73.
[] [PMID: 17005785]
Vieira JN, Gonçalves CL, Villarreal JPV, et al. Chemical composition of essential oils from the apiaceae family, cytotoxicity, and their antifungal activity in vitro against candida species from oral cavity. Braz J Biol 2019; 79(3): 432-7.
[] [PMID: 30328892]
Carbone C, Teixeira MDC, Sousa MDC, et al. Clotrimazole-loaded mediterranean essential oils NLC: a synergic treatment of Candida skin infections. Pharmaceutics 2019; 11(5): 231.
[] [PMID: 31085997]
Baj T, Biernasiuk A, Wróbel R, Malm A. Chemical composition and in vitro activity of Origanum vulgare L., Satureja hortensis L., Thymus serpyllum L. and Thymus vulgaris L. essential oils towards oral isolates of Candida albicans and Candida glabrata. Open Chem 2020; 18: 108-18.
Sharifzadeh A, Shokri H. Antifungal activity of essential oils from Iranian plants against fluconazole-resistant and fluconazole-susceptible Candida albicans. Avicenna J Phytomed 2016; 6(2): 215-22.
[PMID: 27222835]
Mahboubi M, Mahdizadeh E, Tabar HR. The anti-candidal activity of Pelargonium graveolens essential oils against clinical isolates of Candida albicans. Infectio 2018; 22: 9-12.
Powers CN, Satyal P, Mayo JA, McFeeters H, McFeeters RL. Bigger data approach to analysis of essential oils and their antifungal activity against Aspergillus niger, Candida albicans, and Cryptococcus neoformans. Molecules 2019; 24(16): 2868.
[] [PMID: 31394798]
Linhares Neto MV, da Silva RO, de Oliveira FF, Costa LCB, Conceição AO, de Oliveira RA. Avaliation anti-Candida of essential oils from three medicinal plants species (Astereaceae). S Afr J Bot 2018; 115: 132-7.
Gevú KV, Lima HRP, Neves IA. Chemical composition and anti-candida and anti-trypanosoma cruzi activities of essential oils from the rhizomes and leaves of Brazilian species of renealmia L. fil. Rec Nat Prod 2019; 13: 268-80.
Bouslimani A, Sanchez LM, Garg N, Dorrestein PC. Mass spectrometry of natural products: current, emerging and future technologies. Nat Prod Rep 2014; 31(6): 718-29.
[] [PMID: 24801551]
Hashmi LS, Hossain MA, Weli AM, Al-Riyami Q, Al-Sabahi JN. Gas chromatography-mass spectrometry analysis of different organic crude extracts from the local medicinal plant of Thymus vulgaris L. Asian Pac J Trop Biomed 2013; 3(1): 69-73.
[] [PMID: 23570020]
Cutillas AB, Carrasco A, Martinez-Gutierrez R, Tomas V, Tudela J. Thymus mastichina L. essential oils from Murcia (Spain): Composition and antioxidant, antienzymatic and antimicrobial bioactivities. PLoS One 2018; 13(1)e0190790
[] [PMID: 29304179]
Azevedo MM, Chaves FC, Almeida CA, et al. Antioxidant and antimicrobial activities of 7-hydroxy-calamenene-rich essential oils from Croton cajucara Benth. Molecules 2013; 18(1): 1128-37.
[] [PMID: 23325101]
Hossein M, Hamed MS, Amin Z, Rahman D. Chemical composition of essential oil of Stachysbyzantina from north-west Iran. J Ess O B Plant 2013; 16: 334-7.
Santana LC. Mikaniaglomerata: Phytochemical, pharmacological, and neurochemical study. Evidence-based complementary and alternative medicine :eCAM 2014; 2014: 710410..
Yildiz H. Chemical composition, antimicrobial, and antioxidant activities of essential oil and ethanol extract of Coriandrum sativum L. leaves from Turkey. Int J Food Prop 2016; 19: 1593-603.
Iqbal Z, Akhtar M, Sabri MU, Altaf A. Chemical composition of ocimum sanctum essential oil by GC-MS analysis. Nat Prod Chem Res 2020; 8: 6.
Tawfeeq A, Faisal A, Abaas M, Ali IA. Isolation, quantification, and identification of rosmarinic acid, gas chromatography-mass spectrometry analysis of essential oil, cytotoxic effect, and antimicrobial investigation of rosmarinusofficinalis leaves. A J of Pharma and Clin Res 2018; 11: 126..
Hanaa M, Sallam YI, El-Leithy AS, Aly SE. Lemongrass (Cymbopogoncitratus) essential oil as affectedby drying methods A.R. Ann Agric Sci 2012; 57: 113-6.
Mamoun SM. Abd El-Kareem, Mohamed A. Rabbih, Hosam O. Elansary, and Fahed A. Al-Mana. M. Mass Spectral Fragmentation of Pelargonium graveolens essential oil using GC-MS Semi-Empirical Calculations and Biological Potential. Processes (Basel) 2020; 8: 128.
Munda S, Pandey SM, Dutta S, Baruah J, Lal M. Antioxidant activity, antibacterial activity and chemical composition of essential oil of Artemisia vulgaris L. leaves from northeast India. J of Ess O B Plants 2019; 22: 368.
Malik S, de Mesquita LSS, Silva CR, et al. Chemical profile and biological activities of essential oil from Artemisia vulgaris L. cultivated in Brazil. Pharmaceuticals (Basel) 2019; 12(2): 49.
[] [PMID: 30939762]
Duarte MCT, Figueira GM, Sartoratto A, Rehder VLG, Delarmelina C. Anti-Candida activity of Brazilian medicinal plants. J Ethnopharmacol 2005; 97(2): 305-11.
[] [PMID: 15707770]
Ashour HM. Antibacterial, antifungal, and anticancer activities of volatile oils and extracts from stems, leaves, and flowers of Eucalyptus sideroxylon and Eucalyptus torquata. Cancer Biol Ther 2008; 7(3): 399-403.
[] [PMID: 18075306]
Begnami AF, Duarte MCT, Furletti V, Rehder VLG. Antimicrobial potential of Coriandrum sativum L. against different Candida species in vitro. Food Chem 2010; 118: 74-7.
Unlu M, Ergene E, Unlu GV, Zeytinoglu HS, Vural N. Composition, antimicrobial activity and in vitro cytotoxicity of essential oil from Cinnamomum zeylanicum Blume (Lauraceae). Food Chem Toxicol 2010; 48(11): 3274-80.
[] [PMID: 20828600]
Khosravi AR, Shokri H, Kermani S, Dakhili M, Madani M, Parsa S. Antifungal properties of Artemisia sieberi and Origanum vulgare essential oils against Candida glabrata isolates obtained from patients with vulvovaginal candidiasis. J Mycol Med 2011; 21: 93-9.
Wang Y, Zeng H, Tian J. In vitro and in vivo activities of essential oil from the seed of Anethum graveolens L against Candida spp. Evidence-based Complement Altern Med 2011.
De Castro RD, Lima EO. Anti-candida activity and chemical composition of cinnamomum zeylanicum blume essential oil. Braz Arch Biol Technol 2103(56): 749-55.
Lakhrissi B, Boukhraz A, Barrahi ME, Hartiti H, Ouhssine M. Antifungal activity of essential oil of oregano (Origanum vulgare), marjoram (Origanum majorana) and synergy of two essential oils against Candida albicans. IntJ Res Stud Sci Eng Technol 2016; 3: 14-7.
Mobin M. MDGC-MS analysis of essential oils from Protium heptaphyllum (Aubl.) and their antifungal activity against Candidaspecies. Rev Bras Plantas Med 2016; 18: 531-8.
Nikolić M, Smiljković M, Marković T, et al. Sensitivity of clinical isolates of Candida to essential oils from Burseraceae family. EXCLI J 2016; 15: 280-9.
[PMID: 27330531]
Costa M. Essential oils from leaves of medicinal plants of brazilian flora: chemical composition and activity against Candida species. Medicines (Basel) 2017; 4: 27.
Fontenelle RO. Effect of essential oils from Mangifera indica L. cultivars on the antifungal susceptibility of Candida spp. strains isolated from dogs. Rev Bras Saúde Prod Anim 2017; 18: 337-46.
Hamdi A, Majouli K, Flamini G, Marzouk B, Marzouk Z, Heyden YV. Antioxidant and anticandidal activities of the Tunisian Haplophyllum tuberculatum (Forssk.) A. Juss essential oils. S Afr J Bot 2017; 112: 210-4.
Katiraee F, Ahmadi Afshar S, Rahimi Pirmahalleh SF, Shokri H. In vitro antifungal activity of essential oils extracted from plants against fluconazole-susceptible and -resistant Candida albicans. Curr Med Mycol 2017; 3(2): 1-6.
[] [PMID: 29354774]
Ksouri S, Djebir S, Bentorki AA, Gouri A, Hadef Y, Benakhla A. Antifungal activity of essential oils extract from Origanum floribundum Munby, Rosmarinus officinalis L. and Thymus ciliatus Desf. against Candida albicans isolated from bovine clinical mastitis. J Mycol Med 2017; 27(2): 245-9.
[] [PMID: 28454927]
Minooeianhaghighi MH, Sepehrian L, Shokri H. Antifungal effects of Lavandula binaludensis and Cuminum cyminum essential oils against Candida albicans strains isolated from patients with recurrent vulvovaginal candidiasis. J Mycol Med 2017; 27(1): 65-71.
[] [PMID: 27751723]
Duran N, Kaya DA. Antifungal activity of Origanum syriacum L. essential oils against Candida spp. 7th International Conference on Advanced Materials and Systems. 81-5.
Ludwig A, de Jesus FPK, Dutra V, Cândido SL, Alves SH, Santurio JM. Susceptibility profile of Candida rugosa (Diutina rugosa) against antifungals and compounds of essential oils. J Mycol Med 2019; 29(2): 154-7.
[] [PMID: 30956064]
Azeez DA. Antifungal activity of mixture Eugenia aromaticum and Thymus vulgaris essential oils against Candida albicans clinical strains in Al-Muthanna province. Indian J Public Health Res Dev 2020; 11: 1184-7.

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