Abstract
H5N1 avian influenza virus (AIV) has caused widespread infections in poultry and wild birds, and has the potential to emerge as a pandemic threat to human. Nucleic acid-based drugs are promising classes of therapeutic agents that have important clinical applications for the prevention and treatment of viral diseases.In this review, a breif overview is made in the use of antisense technology in gene suppression. The main focus is on the features of a modified short RNA oligonucleotide (nanoRNAs) and its use in suppression of H5N1 influenza viral replication, including the design, efficacy of nanoRNAs and the evaluation of these agents from in vitro activity to efficacy in animal protection studies.
Keywords: RNA oligonucleotides, nanoRNA, CEF cells, H5N1 virus infection, influenza
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Inhibition of Highly Pathogenic Avian H5N1 Influenza Virus Replication by NanoRNA Oligonucleotides
Volume: 7 Issue: 2
Author(s): Rod Dale, Ming Wang and Lun-Quan Sun
Affiliation:
Keywords: RNA oligonucleotides, nanoRNA, CEF cells, H5N1 virus infection, influenza
Abstract: H5N1 avian influenza virus (AIV) has caused widespread infections in poultry and wild birds, and has the potential to emerge as a pandemic threat to human. Nucleic acid-based drugs are promising classes of therapeutic agents that have important clinical applications for the prevention and treatment of viral diseases.In this review, a breif overview is made in the use of antisense technology in gene suppression. The main focus is on the features of a modified short RNA oligonucleotide (nanoRNAs) and its use in suppression of H5N1 influenza viral replication, including the design, efficacy of nanoRNAs and the evaluation of these agents from in vitro activity to efficacy in animal protection studies.
Export Options
About this article
Cite this article as:
Dale Rod, Wang Ming and Sun Lun-Quan, Inhibition of Highly Pathogenic Avian H5N1 Influenza Virus Replication by NanoRNA Oligonucleotides, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2008; 7 (2) . https://dx.doi.org/10.2174/187152308784533140
DOI https://dx.doi.org/10.2174/187152308784533140 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
New Molecules and Strategies in the Field of Anticancer Agents
Current Medicinal Chemistry - Anti-Cancer Agents Targeting Prenylated RAS Modifying Enzymes in Cancer Cells
Current Signal Transduction Therapy Pharmacological Intervention at CCR1 and CCR5 as an Approach for Cancer: Help or Hindrance
Current Topics in Medicinal Chemistry Neurotrophic Factors for Retinal Ganglion Cell Neuropathy - With a Special Reference to Diabetic Neuropathy in the Retina
Current Diabetes Reviews The Involvement of Heat Shock Proteins and Related Molecules in the Resistance to Therapies in Breast and Gynecologic Cancer
Current Cancer Therapy Reviews BUB1B Promotes Proliferation of Prostate Cancer via Transcriptional Regulation of MELK
Anti-Cancer Agents in Medicinal Chemistry Recent Advances in Semisynthesis, Biosynthesis, Biological Activities,Mode of Action, and Structure-Activity Relationship of Podophyllotoxins:An Update (2008-2010)
Mini-Reviews in Medicinal Chemistry VEGF Inhibitors in Cancer Therapy
Current Pharmaceutical Design Development of Prodrugs for Enzyme-Mediated, Tumor-Selective Therapy
Current Medicinal Chemistry - Anti-Cancer Agents The Therapeutic Potential of ADAM15
Current Pharmaceutical Design Antibody Gene Therapy: Getting Closer to Clinical Application?
Current Gene Therapy Subject Index to Volume 3
Current Drug Targets - Infectious Disorders FTD and ALS: A Tale of Two Diseases
Current Alzheimer Research Cellular Functions of Vaults and their Involvement in Multidrug Resistance
Current Drug Targets CXCL12-CXCR4 Axis in Angiogenesis, Metastasis and Stem Cell Mobilization
Current Pharmaceutical Design Molecular Biomarkers for Lung Adenocarcinoma: A Short Review
Current Cancer Therapy Reviews Commercial Opportunities and Ethical Pitfalls in Personalized Medicine: A Myriad of Reasons to Revisit the Myriad Genetics Saga
Current Pharmacogenomics and Personalized Medicine Silencing of Disease-related Genes by Small Interfering RNAs
Current Molecular Medicine Current Biological Therapies for Inflammatory Bowel Disease
Current Pharmaceutical Design Cardiovascular Complications of HIV Infection and Treatment
Cardiovascular & Hematological Agents in Medicinal Chemistry