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Current Diabetes Reviews

Editor-in-Chief

ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Mini-Review Article

Treating to Target Glycaemia in Type 2 Diabetes Pregnancy

Author(s): Jennifer M. Yamamoto* and Helen R. Murphy

Volume 19, Issue 2, 2023

Published on: 12 April, 2022

Article ID: e010222200742 Pages: 11

DOI: 10.2174/1573399818666220201111200

Price: $65

Abstract

There is an increasing awareness that in those who develop early-onset (18-39 years) adult type 2 diabetes, an increase in insulin resistance, deterioration in beta-cell, and clustering of cardiovascular risk factors are particularly pronounced. Pregnant women with type 2 diabetes have additional risk factors for serious adverse pregnancy outcomes as well as added barriers regarding healthcare access before, during, and after pregnancy. Compared to pregnant women with type 1 diabetes, those with type 2 diabetes are older, have higher body mass index (BMI), with more metabolic comorbidities and concomitant medications, are more likely to belong to minority ethnic groups, and live in the highest areas of socio-economic deprivation. Approximately, one in seven pregnant women with type 2 diabetes (median age 34 years) are taking ACE-inhibitors, statins (13%), and/or other potentially harmful diabetes therapies (7%). Fewer than one in four are taking a high dose of folic acid before pregnancy, which may suggest that planning for pregnancy is not a priority for women themselves, their healthcare professionals, or the healthcare system. Knowledge of the epidemiology, pathophysiology, and unique management considerations of early-onset type 2 diabetes is essential to providing evidence-based care to pregnant women with type 2 diabetes. This narrative review will discuss contemporary data regarding type 2 diabetes pregnancy outcomes and the increasing recognition that different types of diabetes may require different treatment strategies before, during, and after pregnancy.

Keywords: Diabetes, type 2 diabetes, pregnancy, pre-pregnancy care, continuous glucose monitoring, glycaemia.

[1]
Lin X, Xu Y, Pan X, et al. Global, regional, and national burden and trend of diabetes in 195 countries and territories: An analysis from 1990 to 2025. Sci Rep 2020; 10(1): 14790.
[http://dx.doi.org/10.1038/s41598-020-71908-9] [PMID: 32901098]
[2]
International Diabetes Federation. IDF Diabetes Atlas. 9th ed. Brussels, Belgium 2019. Available from: https://www.diabetesatlas.org
[3]
Guariguata L, Linnenkamp U, Beagley J, Whiting DR, Cho NH. Global estimates of the prevalence of hyperglycaemia in pregnancy. Diabetes Res Clin Pract 2014; 103(2): 176-85.
[http://dx.doi.org/10.1016/j.diabres.2013.11.003] [PMID: 24300020]
[4]
Mackin ST, Nelson SM, Kerssens JJ, et al. SDRN Epidemiology Group. Diabetes and pregnancy: National trends over a 15 year period. Diabetologia 2018; 61(5): 1081-8.
[http://dx.doi.org/10.1007/s00125-017-4529-3] [PMID: 29322220]
[5]
Murphy HR, Bell R, Cartwright C, et al. Improved pregnancy outcomes in women with type 1 and type 2 diabetes but substantial clinic-to-clinic variations: A prospective nationwide study. Diabetologia 2017; 60(9): 1668-77.
[http://dx.doi.org/10.1007/s00125-017-4314-3] [PMID: 28597075]
[6]
Vounzoulaki E, Khunti K, Abner SC, Tan BK, Davies MJ, Gillies CL. Progression to type 2 diabetes in women with a known history of gestational diabetes: Systematic review and meta-analysis. BMJ 2020; 369: m1361.
[http://dx.doi.org/10.1136/bmj.m1361] [PMID: 32404325]
[7]
Bjornstad P, Drews KL, Caprio S, et al. TODAY Study Group. Long-term complications in youth-onset type 2 diabetes. N Engl J Med 2021; 385(5): 416-26.
[http://dx.doi.org/10.1056/NEJMoa2100165] [PMID: 34320286]
[8]
Murphy HR, Howgate C, O’Keefe J, et al. National Pregnancy in Diabetes (NPID) advisory group. Characteristics and outcomes of pregnant women with type 1 or type 2 diabetes: A 5-year national population-based cohort study. Lancet Diabetes Endocrinol 2021; 9(3): 153-64.
[http://dx.doi.org/10.1016/S2213-8587(20)30406-X] [PMID: 33516295]
[9]
Mackin ST, Nelson SM, Wild SH, Colhoun HM, Wood R, Lindsay RS. SDRN Epidemiology Group and Scottish Diabetes Group Pregnancy subgroup. Factors associated with stillbirth in women with diabetes. Diabetologia 2019; 62(10): 1938-47.
[http://dx.doi.org/10.1007/s00125-019-4943-9] [PMID: 31353418]
[10]
Roland JM, Murphy HR, Ball V, Northcote-Wright J, Temple RC. The pregnancies of women with Type 2 diabetes: Poor outcomes but opportunities for improvement. Diabet Med 2005; 22(12): 1774-7.
[http://dx.doi.org/10.1111/j.1464-5491.2005.01784.x] [PMID: 16401329]
[11]
Clausen TD, Mathiesen E, Ekbom P, Hellmuth E, Mandrup-Poulsen T, Damm P. Poor pregnancy outcome in women with type 2 diabetes. Diabetes Care 2005; 28(2): 323-8.
[http://dx.doi.org/10.2337/diacare.28.2.323] [PMID: 15677787]
[12]
Dunne F, Brydon P, Smith K, Gee H. Pregnancy in women with type 2 diabetes: 12 years outcome data 1990-2002. Diabet Med 2003; 20(9): 734-8.
[http://dx.doi.org/10.1046/j.1464-5491.2003.01017.x] [PMID: 12925053]
[13]
Cundy T, Gamble G, Neale L, et al. Differing causes of pregnancy loss in type 1 and type 2 diabetes. Diabetes Care 2007; 30(10): 2603-7.
[http://dx.doi.org/10.2337/dc07-0555] [PMID: 17586739]
[14]
Balsells M, García-Patterson A, Gich I, Corcoy R. Maternal and fetal outcome in women with type 2 versus type 1 diabetes mellitus: A systematic review and metaanalysis. J Clin Endocrinol Metab 2009; 94(11): 4284-91.
[http://dx.doi.org/10.1210/jc.2009-1231] [PMID: 19808847]
[15]
Macintosh MC, Fleming KM, Bailey JA, et al. Perinatal mortality and congenital anomalies in babies of women with type 1 or type 2 diabetes in England, Wales, and Northern Ireland: Population based study. BMJ 2006; 333(7560): 177.
[http://dx.doi.org/10.1136/bmj.38856.692986.AE] [PMID: 16782722]
[16]
Murphy HR, Steel SA, Roland JM, et al. East Anglia Study Group for Improving Pregnancy Outcomes in Women with Diabetes (EASIPOD). Obstetric and perinatal outcomes in pregnancies complicated by Type 1 and Type 2 diabetes: Influences of glycaemic control, obesity and social disadvantage. Diabet Med 2011; 28(9): 1060-7.
[http://dx.doi.org/10.1111/j.1464-5491.2011.03333.x] [PMID: 21843303]
[17]
Sacks DA, Feig DS. Caring for pregnant women whose diabetes antedates pregnancy: Is there room for improvement? Diabetologia 2018; 61(5): 1022-6.
[http://dx.doi.org/10.1007/s00125-018-4565-7] [PMID: 29411042]
[18]
García-Patterson A, Gich I, Amini SB, Catalano PM, de Leiva A, Corcoy R. Insulin requirements throughout pregnancy in women with type 1 diabetes mellitus: Three changes of direction. Diabetologia 2010; 53(3): 446-51.
[http://dx.doi.org/10.1007/s00125-009-1633-z] [PMID: 20013109]
[19]
García-Patterson A, Ovejero D, Miñambres I, et al. Both glycaemic control and insulin dose during pregnancy in women with type 1 diabetes are associated with neonatal anthropometric measures and placental weight. Diabetes Metab Res Rev 2020; 36(5)e3300
[http://dx.doi.org/10.1002/dmrr.3300] [PMID: 32048800]
[20]
Murphy HR, Elleri D, Allen JM, et al. Pathophysiology of postprandial hyperglycaemia in women with type 1 diabetes during pregnancy. Diabetologia 2012; 55(2): 282-93.
[http://dx.doi.org/10.1007/s00125-011-2363-6] [PMID: 22080230]
[21]
Catalano PM, Drago NM, Amini SB. Longitudinal changes in pancreatic beta-cell function and metabolic clearance rate of insulin in pregnant women with normal and abnormal glucose tolerance. Diabetes Care 1998; 21(3): 403-8.
[http://dx.doi.org/10.2337/diacare.21.3.403] [PMID: 9540023]
[22]
Gagnon-Auger M, du Souich P, Baillargeon JP, et al. Dose-dependent delay of the hypoglycemic effect of short-acting insulin analogs in obese subjects with type 2 diabetes: A pharmacokinetic and pharmacodynamic study. Diabetes Care 2010; 33(12): 2502-7.
[http://dx.doi.org/10.2337/dc10-1126] [PMID: 20841613]
[23]
Sandqvist M, Strindberg L, Schmelz M, Lönnroth P, Jansson PA. Impaired delivery of insulin to adipose tissue and skeletal muscle in obese women with postprandial hyperglycemia. J Clin Endocrinol Metab 2011; 96(8): E1320-4.
[http://dx.doi.org/10.1210/jc.2011-0233] [PMID: 21677042]
[24]
Murphy HR, Roland JM, Skinner TC, et al. Effectiveness of a regional prepregnancy care program in women with type 1 and type 2 diabetes: Benefits beyond glycemic control. Diabetes Care 2010; 33(12): 2514-20.
[http://dx.doi.org/10.2337/dc10-1113] [PMID: 21115765]
[25]
Egan AM, Danyliv A, Carmody L, Kirwan B, Dunne FP. A prepregnancy care program for women with diabetes: Effective and cost saving. J Clin Endocrinol Metab 2016; 101(4): 1807-15.
[http://dx.doi.org/10.1210/jc.2015-4046] [PMID: 26918293]
[26]
Wahabi HA, Fayed A, Esmaeil S, et al. Systematic review and meta-analysis of the effectiveness of pre-pregnancy care for women with diabetes for improving maternal and perinatal outcomes. PLoS One 2020; 15(8)e0237571
[http://dx.doi.org/10.1371/journal.pone.0237571] [PMID: 32810195]
[27]
Sargeant JA, Brady EM, Zaccardi F, et al. Adults with early-onset type 2 diabetes (aged 18-39 years) are severely underrepresented in diabetes clinical research trials. Diabetologia 2020; 63(8): 1516-20.
[http://dx.doi.org/10.1007/s00125-020-05174-9] [PMID: 32483683]
[28]
Makda SI, Davies MJ, Wilmot E, et al. Prescribing in pregnancy for women with diabetes: Use of potential teratogenic drugs and contraception. Diabet Med 2013; 30(4): 457-63.
[http://dx.doi.org/10.1111/dme.12051] [PMID: 23110381]
[29]
Hendrieckx C, Morrison M, Audehm R, et al. Women with type 1 diabetes and women with type 2 diabetes differ in knowledge and beliefs about contraception and pregnancy. Diabet Med 2021; 38(4)e14521
[http://dx.doi.org/10.1111/dme.14521] [PMID: 33434298]
[30]
Forde R, Patelarou EE, Forbes A. The experiences of prepregnancy care for women with type 2 diabetes mellitus: A meta-synthesis. Int J Womens Health 2016; 8: 691-703.
[http://dx.doi.org/10.2147/IJWH.S115955] [PMID: 27994487]
[31]
Murphy HR, Temple RC, Ball VE, et al. East Anglia Study group for Improving Pregnancy Outcomes in women with Diabetes (EASIPOD). Personal experiences of women with diabetes who do not attend pre-pregnancy care. Diabet Med 2010; 27(1): 92-100.
[http://dx.doi.org/10.1111/j.1464-5491.2009.02890.x] [PMID: 20121895]
[32]
Murphy HR, Bell R, Dornhorst A, Forde R, Lewis-Barned N. Pregnancy in Diabetes: Challenges and opportunities for improving pregnancy outcomes. Diabet Med 2018; 35(3): 292-9.
[http://dx.doi.org/10.1111/dme.13579] [PMID: 29337383]
[33]
Malacova E, Regan A, Nassar N, et al. Risk of stillbirth, preterm delivery, and fetal growth restriction following exposure in a previous birth: Systematic review and meta-analysis. BJOG 2018; 125(2): 183-92.
[http://dx.doi.org/10.1111/1471-0528.14906] [PMID: 28856792]
[34]
Tennant PW, Bilous RW, Prathapan S, Bell R. Risk and recurrence of serious adverse outcomes in the first and second pregnancies of women with preexisting diabetes. Diabetes Care 2015; 38(4): 610-9.
[http://dx.doi.org/10.2337/dc14-1888] [PMID: 25573880]
[35]
Yamamoto JM, Hughes DJF, Evans ML, et al. Community-based pre-pregnancy care programme improves pregnancy preparation in women with pregestational diabetes. Diabetologia 2018; 61(7): 1528-37.
[http://dx.doi.org/10.1007/s00125-018-4613-3] [PMID: 29744539]
[36]
National Institute for Health and Care Excellence. Diabetes in pregnancy: management from preconception to the postnatal period. 2015. Available from: https://www.nice.org.uk/guidance/ng3/resources/diabetes-in-pregnancy-management-from-preconception-to-the-postnatal-period-51038446021
[37]
Feig DS, Berger H, Donovan L, et al. Diabetes canada clinical practice guidelines expert committee. Diabetes and pregnancy. Can J Diabetes 2018; 42 (Suppl. 1): S255-82.
[http://dx.doi.org/10.1016/j.jcjd.2017.10.038] [PMID: 29650105]
[38]
Lean MEJ. Low-calorie diets in the management of type 2 diabetes mellitus. Nat Rev Endocrinol 2019; 15(5): 251-2.
[http://dx.doi.org/10.1038/s41574-019-0186-6] [PMID: 30833703]
[39]
Mahajan A, Donovan LE, Vallee R, Yamamoto JM. Evidenced-based nutrition for gestational diabetes mellitus. Curr Diab Rep 2019; 19(10): 94.
[http://dx.doi.org/10.1007/s11892-019-1208-4] [PMID: 31473839]
[40]
Institute of Medicine. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. Washington, DC: The National Academies Press 2005; p. 358.
[41]
Ásbjörnsdóttir B, Ronneby H, Vestgaard M, et al. Lower daily carbohydrate consumption than recommended by the Institute of Medicine is common among women with type 2 diabetes in early pregnancy in Denmark. Diabetes Res Clin Pract 2019; 152: 88-95.
[http://dx.doi.org/10.1016/j.diabres.2019.05.012] [PMID: 31121274]
[42]
Neoh SL, Yamamoto JM, Feig DS, Murphy HR, Group CC. CONCEPTT Collaborative Group. Dietary patterns of insulin pump and multiple daily injection users during type 1 diabetes pregnancy. Diabetes Care 2020; 43(1): e5-7.
[http://dx.doi.org/10.2337/dc19-1908] [PMID: 31694860]
[43]
Yamamoto JM, Kellett JE, Balsells M, et al. Gestational diabetes mellitus and diet: A systematic review and meta-analysis of randomized controlled trials examining the impact of modified dietary interventions on maternal glucose control and neonatal birth weight. Diabetes Care 2018; 41(7): 1346-61.
[http://dx.doi.org/10.2337/dc18-0102] [PMID: 29934478]
[44]
Yong HY, Mohd Shariff Z, Mohd Yusof BN, et al. Higher Parity, pre-pregnancy BMI and rate of gestational weight gain are associated with gestational diabetes mellitus in food insecure women. Int J Environ Res Public Health 2021; 18(5): 2694.
[http://dx.doi.org/10.3390/ijerph18052694] [PMID: 33800084]
[45]
Thomas MK, Lammert LJ, Beverly EA. Food insecurity and its impact on body weight, type 2 diabetes, cardiovascular disease, and mental health. Curr Cardiovasc Risk Rep 2021; 15(9): 15.
[http://dx.doi.org/10.1007/s12170-021-00679-3] [PMID: 34249217]
[46]
Maitland R, Patel N, Barr S, et al. A slow-digesting, low-glycemic load nutritional beverage improves glucose tolerance in obese pregnant women without gestational diabetes. Diabetes Technol Ther 2018; 20(10): 672-80.
[http://dx.doi.org/10.1089/dia.2018.0102] [PMID: 30204483]
[47]
Hodson K, Dalla Man C, Smith FE, et al. Liver triacylglycerol content and gestational diabetes: Effects of moderate energy restriction. Diabetologia 2017; 60(2): 306-13.
[http://dx.doi.org/10.1007/s00125-016-4143-9] [PMID: 27817155]
[48]
Brosnahan N, Leslie W, McCombie L, et al. Brief formula low-energy-diet for relapse management during weight loss maintenance in the Diabetes Remission Clinical Trial (DiRECT). J Hum Nutr Diet 2021; 34(3): 472-9.
[http://dx.doi.org/10.1111/jhn.12839] [PMID: 33406285]
[49]
Olbers T, Beamish AJ, Gronowitz E, et al. Laparoscopic Roux-en-Y gastric bypass in adolescents with severe obesity (AMOS): A prospective, 5-year, Swedish nationwide study. Lancet Diabetes Endocrinol 2017; 5(3): 174-83.
[http://dx.doi.org/10.1016/S2213-8587(16)30424-7] [PMID: 28065734]
[50]
Inge TH, Laffel LM, Jenkins TM, et al. Teen–longitudinal assessment of bariatric surgery (teen-labs) and treatment options of type 2 diabetes in adolescents and youth (today) consortia. Comparison of surgical and medical therapy for type 2 diabetes in severely obese adolescents. JAMA Pediatr 2018; 172(5): 452-60.
[http://dx.doi.org/10.1001/jamapediatrics.2017.5763] [PMID: 29532078]
[51]
Gardosi J, Frances A, Williams M, Hugh O, Ford C, Qasam M. Customised weight centile calculator grow v804. UK: Gestation Network 2019.
[52]
Feig DS, Donovan LE, Corcoy R, et al. CONCEPTT Collaborative Group. Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): A multicentre international randomised controlled trial. Lancet 2017; 390(10110): 2347-59.
[http://dx.doi.org/10.1016/S0140-6736(17)32400-5] [PMID: 28923465]
[53]
Yamamoto JM, Murphy HR. Benefits of real-time continuous glucose monitoring in pregnancy. Diabetes Technol Ther 2021; 23(S1): S8-S14.
[http://dx.doi.org/10.1089/dia.2020.0667] [PMID: 33512267]
[54]
Murphy HR, Rayman G, Lewis K, et al. Effectiveness of continuous glucose monitoring in pregnant women with diabetes: Randomised clinical trial. BMJ 2008; 337: a1680.
[http://dx.doi.org/10.1136/bmj.a1680] [PMID: 18818254]
[55]
Voormolen DN, DeVries JH, Sanson RME, et al. Continuous glucose monitoring during diabetic pregnancy (GlucoMOMS): A multicentre randomized controlled trial. Diabetes Obes Metab 2018; 20(8): 1894-902.
[http://dx.doi.org/10.1111/dom.13310] [PMID: 29603547]
[56]
Secher AL, Ringholm L, Andersen HU, Damm P, Mathiesen ER. The effect of real-time continuous glucose monitoring in pregnant women with diabetes: A randomized controlled trial. Diabetes Care 2013; 36(7): 1877-83.
[http://dx.doi.org/10.2337/dc12-2360] [PMID: 23349548]
[57]
Murphy HR, Rayman G, Duffield K, et al. Changes in the glycemic profiles of women with type 1 and type 2 diabetes during pregnancy. Diabetes Care 2007; 30(11): 2785-91.
[http://dx.doi.org/10.2337/dc07-0500] [PMID: 17666464]
[58]
Battelino T, Danne T, Bergenstal RM, et al. Clinical targets for continuous glucose monitoring data interpretation: Recommendations from the international consensus on time in range. Diabetes Care 2019; 42(8): 1593-603.
[http://dx.doi.org/10.2337/dci19-0028] [PMID: 31177185]
[59]
Lee D, Booth GL, Ray JG, Ling V, Feig DS. Undiagnosed type 2 diabetes during pregnancy is associated with increased perinatal mortality: A large population-based cohort study in Ontario, Canada. Diabet Med 2020; 37(10): 1696-704.
[http://dx.doi.org/10.1111/dme.14250] [PMID: 31994233]
[60]
Tennant PW, Glinianaia SV, Bilous RW, Rankin J, Bell R. Pre-existing diabetes, maternal glycated haemoglobin, and the risks of fetal and infant death: A population-based study. Diabetologia 2014; 57(2): 285-94.
[http://dx.doi.org/10.1007/s00125-013-3108-5] [PMID: 24292565]
[61]
Viollet B, Guigas B, Sanz Garcia N, Leclerc J, Foretz M, Andreelli F. Cellular and molecular mechanisms of metformin: An overview. Clin Sci (Lond) 2012; 122(6): 253-70.
[http://dx.doi.org/10.1042/CS20110386] [PMID: 22117616]
[62]
Hyer S, Balani J, Shehata H. Metformin in pregnancy: Mechanisms and clinical applications. Int J Mol Sci 2018; 19(7)E1954
[http://dx.doi.org/10.3390/ijms19071954] [PMID: 29973490]
[63]
Feig DS, Donovan LE, Zinman B, et al. MiTy Collaborative Group. Metformin in women with type 2 diabetes in pregnancy (MiTy): A multicentre, international, randomised, placebo-controlled trial. Lancet Diabetes Endocrinol 2020; 8(10): 834-44.
[http://dx.doi.org/10.1016/S2213-8587(20)30310-7] [PMID: 32946820]
[64]
Yamamoto JM, Donovan LE, Mohammad K, Wood SL. Severe neonatal hypoglycaemia and intrapartum glycaemic control in pregnancies complicated by type 1, type 2 and gestational diabetes. Diabet Med 2020; 37(1): 138-46.
[http://dx.doi.org/10.1111/dme.14137] [PMID: 31529717]
[65]
Ruth C, Sellers E, Chartrand C, McLeod L, Prior H, Sirski M, et al. Type 2 diabetes in manitoba autum. Winnipeg: Manitoba Manitoba Centre for Health Policy 2020.
[66]
Meek CL, Corcoy R, Asztalos E, et al. CONCEPTT collaborative group. Which growth standards should be used to identify large- and small-for-gestational age infants of mothers with type 1 diabetes? A pre-specified analysis of the CONCEPTT trial. BMC Pregnancy Childbirth 2021; 21(1): 96.
[http://dx.doi.org/10.1186/s12884-021-03554-6] [PMID: 33514342]
[67]
Villegas R, Gao YT, Yang G, et al. Duration of breast-feeding and the incidence of type 2 diabetes mellitus in the Shanghai Women’s Health Study. Diabetologia 2008; 51(2): 258-66.
[http://dx.doi.org/10.1007/s00125-007-0885-8] [PMID: 18040660]
[68]
Kjos SL, Henry O, Lee RM, Buchanan TA, Mishell DR Jr. The effect of lactation on glucose and lipid metabolism in women with recent gestational diabetes. Obstet Gynecol 1993; 82(3): 451-5.
[PMID: 8355952]
[69]
Martens PJ, Shafer LA, Dean HJ, et al. Breastfeeding initiation associated with reduced incidence of diabetes in mothers and offspring. Obstet Gynecol 2016; 128(5): 1095-104.
[http://dx.doi.org/10.1097/AOG.0000000000001689] [PMID: 27741196]
[70]
Schaefer-Graf UM, Hartmann R, Pawliczak J, et al. Association of breast-feeding and early childhood overweight in children from mothers with gestational diabetes mellitus. Diabetes Care 2006; 29(5): 1105-7.
[http://dx.doi.org/10.2337/dc05-2413] [PMID: 16644645]
[71]
Finkelstein SA, Keely E, Feig DS, Tu X, Yasseen AS III, Walker M. Breastfeeding in women with diabetes: Lower rates despite greater rewards. A population-based study. Diabet Med 2013; 30(9): 1094-101.
[http://dx.doi.org/10.1111/dme.12238] [PMID: 23692476]
[72]
Chamberlain CR, Wilson AN, Amir LH, et al. Low rates of predominant breastfeeding in hospital after gestational diabetes, particularly among Indigenous women in Australia. Aust N Z J Public Health 2017; 41(2): 144-50.
[http://dx.doi.org/10.1111/1753-6405.12629] [PMID: 28110518]
[73]
Nommsen-Rivers LA, Chantry CJ, Peerson JM, Cohen RJ, Dewey KG. Delayed onset of lactogenesis among first-time mothers is related to maternal obesity and factors associated with ineffective breastfeeding. Am J Clin Nutr 2010; 92(3): 574-84.
[http://dx.doi.org/10.3945/ajcn.2010.29192] [PMID: 20573792]
[74]
De Bortoli J, Amir LH. Is onset of lactation delayed in women with diabetes in pregnancy? A systematic review. Diabet Med 2016; 33(1): 17-24.
[http://dx.doi.org/10.1111/dme.12846] [PMID: 26113051]
[75]
Hale TW, Kristensen JH, Hackett LP, Kohan R, Ilett KF. Transfer of metformin into human milk. Diabetologia 2002; 45(11): 1509-14.
[http://dx.doi.org/10.1007/s00125-002-0939-x] [PMID: 12436333]
[76]
Gardiner SJ, Kirkpatrick CM, Begg EJ, Zhang M, Moore MP, Saville DJ. Transfer of metformin into human milk. Clin Pharmacol Ther 2003; 73(1): 71-7.
[http://dx.doi.org/10.1067/mcp.2003.9] [PMID: 12545145]
[77]
Nommsen-Rivers L, Thompson A, Riddle S, Ward L, Wagner E, King E. Feasibility and acceptability of metformin to augment low milk supply: A pilot randomized controlled trial. J Hum Lact 2019; 35(2): 261-71.
[http://dx.doi.org/10.1177/0890334418819465] [PMID: 30629889]
[78]
Feig DS, Briggs GG, Kraemer JM, et al. Transfer of glyburide and glipizide into breast milk. Diabetes Care 2005; 28(8): 1851-5.
[http://dx.doi.org/10.2337/diacare.28.8.1851] [PMID: 16043722]
[79]
Kulski JK, Hartmann PE. Milk insulin, GH and TSH: relationship to changes in milk lactose, glucose and protein during lactogenesis in women. Endocrinol Exp 1983; 17(3-4): 317-26.
[PMID: 6360660]
[80]
Whitmore TJ, Trengove NJ, Graham DF, Hartmann PE. Analysis of insulin in human breast milk in mothers with type 1 and type 2 diabetes mellitus. Int J Endocrinol 2012; 2012296368
[http://dx.doi.org/10.1155/2012/296368] [PMID: 22500167]
[81]
Grandi SM, Filion KB, Yoon S, et al. Cardiovascular disease-related morbidity and mortality in women with a history of pregnancy complications. Circulation 2019; 139(8): 1069-79.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036748] [PMID: 30779636]
[82]
Guillemette L, Wicklow B, Sellers EAC, et al. Intrauterine exposure to diabetes and risk of cardiovascular disease in adolescence and early adulthood: A population-based birth cohort study. CMAJ 2020; 192(39): E1104-13.
[http://dx.doi.org/10.1503/cmaj.190797] [PMID: 32989023]
[83]
Wicklow BA, Sellers EAC, Sharma AK, et al. Association of gestational diabetes and type 2 diabetes exposure in utero with the development of type 2 diabetes in first nations and non-first nations offspring. JAMA Pediatr 2018; 172(8): 724-31.
[http://dx.doi.org/10.1001/jamapediatrics.2018.1201] [PMID: 29889938]
[84]
Elliott HR, Sharp GC, Relton CL, Lawlor DA. Epigenetics and gestational diabetes: A review of epigenetic epidemiology studies and their use to explore epigenetic mediation and improve prediction. Diabetologia 2019; 62(12): 2171-8.
[http://dx.doi.org/10.1007/s00125-019-05011-8] [PMID: 31624900]
[85]
Yamamoto JM, Benham JL, Dewey D, et al. Neurocognitive and behavioural outcomes in offspring exposed to maternal pre-existing diabetes: A systematic review and meta-analysis. Diabetologia 2019; 62(9): 1561-74.
[http://dx.doi.org/10.1007/s00125-019-4923-0] [PMID: 31278412]

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