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Current Protein & Peptide Science


ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

Genetic and Epigenetic Diversity of Protein Molecules Related to SARSCoV- 2 Entry: Where We Are and Where We Should Go?

Author(s): Shiheng Zhu, Fei Chen*, Xiaoyun Li, Yankun Zhang, Xinqing Wang and Chun Luan

Volume 23, Issue 2, 2022

Published on: 07 March, 2022

Page: [70 - 76] Pages: 7

DOI: 10.2174/1389203723666220201160820

Price: $65


The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), has swept the whole world and brought about public health crisis of unprecedented proportions. In the process of SARS-CoV-2 entry, angiotensin-converting enzyme 2 plays a key role. In addition, other protein molecules, such as transmembrane protease/serine 2, FURIN, Cathepsin L, and a disintegrin and metalloproteinase 17 will also affect the interaction between virus and host cells. Since the variations in the virus and human populations could determine the transmissibility of the virus and influence an individual’s susceptibility to SARS-CoV-2 infection and disease outcome, research on the variations of the above protein molecules and their role in COVID-19 is in full swing. In this review, we systematically reviewed viral and host genetic variations related to SARSCoV- 2 entry, as well as the relationship between the diversity of these variations and the COVID-19 pandemic. We aim to provide better insights into the transmission and pathogenesis of COVID-19 from the perspective of genetic variants and epigenetic factors so as to prevent, control, and treat COVID-19, especially among high-risk populations with genetic risk variants.

Keywords: S protein, ACE2, variants, epigenetics, TMPRSS2, COVID-19, gene polymorphism.

Graphical Abstract
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