Review Article

Possible Role of Wnt Signaling Pathway in Diabetic Retinopathy

Author(s): Sheetu Sharma, Tapan Behl*, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harassi, Simona Bungau and Ebrahim Mostafavi*

Volume 23, Issue 15, 2022

Published on: 13 September, 2022

Page: [1372 - 1380] Pages: 9

DOI: 10.2174/1389450123666220301110140

Price: $65

Abstract

The core of impaired vision in working people suffering from insulin-dependent and noninsulin- dependent diabetes mellitus is diabetic retinopathy (DR). The Wnt Protein Ligands family influences various processes; this ensures the cells are able to interact and co-ordinate various mobile functions, including cell growth, division, survival, apoptosis, migration, and cell destiny. The extracellular Wnt signal activates other signals. It is seen that Wnt pathways play an important role in inflammation, oxidative stress, and angiogenesis. It has been illustrated that the canonically preserved Wnt signaling system has a vital role in the homeostasis of adulthood. Developmental disorders in each of these stages will lead to serious eye problems and eventually blindness. There is, therefore, a need to specifically organize and regulate the growth of ocular tissues. In tissue specification and polarities, axonal exhaust, and maintenance of cells, especially in the central nervous system, Wnt/frizzled pathways play an important role. Thus, Wnt route antagonists may act as have been possible therapeutic options in DR by inhibiting aberrant Wnt signals. Elaborative and continued research in this area will help in the advancement of current knowledge in the field of DR, and eventually, this can lead to the development of new therapeutic approaches.

Keywords: Diabetes mellitus, diabetic retinopathy, oxidative stress, angiogenesis, Wnt signaling pathway, canonical pathway, non-canonical pathway.

Graphical Abstract
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