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Endocrine, Metabolic & Immune Disorders - Drug Targets


ISSN (Print): 1871-5303
ISSN (Online): 2212-3873


Searching for a Link between Bone Decay and Diabetes Type 2

Author(s): Ciro G. Isacco, Kieu C.D. Nguyen, Van H. Pham, Gianna Di Palma, Sergey K. Aityan, Diego Tomassone*, Pietro Distratis, Rita Lazzaro, Mario G. Balzanelli and Francesco Inchingolo

Volume 22, Issue 9, 2022

Published on: 24 March, 2022

Page: [904 - 910] Pages: 7

DOI: 10.2174/1871530322666220324150327


The current commentary describes the possible existing link between metabolic diseases such as diabetes type 2 and the degenerative patterns of bones via the molecular mechanism that inhibits the mesenchymal stem cells’ differentiation into osteoblasts and osteocytes.

Keywords: Diabetes type 1-2, regenerative medicine, enteric nervous system (ENS), central nervous system (CNS), mesenchymal stem cells (MSCs), bone marrow (BM), osteoblasts, ageing, bone decay.

Graphical Abstract
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