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Current Bioactive Compounds

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ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Research Article

Inhibitory Effects of Linum usitatissimum Alkaloid on Inflammatory and Nociceptive Responses in Mice

Author(s): Mohamed Sofiane Merakeb, Noureddine Bribi*, Riad Ferhat and Betitera Yanat

Volume 19, Issue 2, 2023

Published on: 03 September, 2022

Article ID: e270422204128 Pages: 7

DOI: 10.2174/1573407218666220427114432

Price: $65

Abstract

Background: Linum usitatissimum is widely used in traditional medicine for the treatment of inflammation, and cardiovascular and respiratory diseases.

Methods: Acute oral toxicity and anti-inflammatory and analgesic effects of total alkaloid extract from Linum usitatissimum seeds (ALU) were investigated in vivo. Xylene-induced ear edema was used to determine the anti-inflammatory effect, and acetic acid-induced writhing, formalin-induced paw licking, and tail-immersion tests were used to investigate the analgesic activity.

Results: Oral administration of ALU (50, 100, and 200 mg/kg) produced anti-inflammatory and analgesic effects. ALU significantly diminished the edema induced by xylene. ALU also significantly reduced the abdominal construction induced by acetic acid. Furthermore, ALU also inhibited responses in both phases of formalin-induced paw licking and increased the reaction time of mice in the tail-immersion test.

Conclusion: These findings suggest the total alkaloid extract from Linum usitatissimum seeds presents significant anti-inflammatory and analgesic effects on chemical, behavioral models of inflammation and nociception in mice.

Keywords: Inflammation, anti-inflammatory, analgesic, Linum usitatissimum, alkaloid, seeds.

Graphical Abstract
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