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Current Gene Therapy


ISSN (Print): 1566-5232
ISSN (Online): 1875-5631

RNA Interference: New Therapeutics in Allergic Diseases

Author(s): Chen-Chen Lee and Bor-Luen Chiang

Volume 8, Issue 4, 2008

Page: [236 - 246] Pages: 11

DOI: 10.2174/156652308785160692

Price: $65


Since the RNAi mechanisms were established in 1990, the rapid progression of RNAi application from animal to clinical trails in human diseases has shown its enormous therapeutic potential. In this review, RNAi therapeutics in allergic diseases is discussed, from RNAi mechanisms and design to challenges and potential targets in allergic diseases. Current reported studies on investigating RNAi therapy in vitro and in vivo are also reviewed. Although there are promising studies in RNAi-based therapy, understanding further the detailed mechanisms of RNAi-based therapy and investigating more effective delivery methods are required for future development.

Keywords: Allergy, RNAi, siRNA, shRNA, gene therapy, transcription factor, cytokine, susceptibility genes

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