Abstract
The generation of an allergic immune response requires at least two signals for complete activation of T cells. Costimulatory molecules are integral to the second signal. In this review, we analyze the costimulatory molecule signaling lymphocytic activation molecule (SLAM) and other recently described SLAM family members. We highlight recent findings that position SLAM as critical for allergic inflammation and its role in modulation of cytokine secretion. Furthermore, a possible role of SLAM as a link between the adaptive and innate immune response is also discussed. Understanding the role of costimulatory molecules, including SLAM and SLAM family members, may elucidate mechanisms involved in the allergic immune response, and suggest potential therapeutic opportunities.
Keywords: Allergy, SLAM, SAP, XLP, costimulatory molecules
Current Molecular Medicine
Title: New Costimulatory Families: Signaling Lymphocytic Activation Molecule in Adaptive Allergic Responses
Volume: 8 Issue: 5
Author(s): Samir S. Makani, Kai Y. Jen and Patricia W. Finn
Affiliation:
Keywords: Allergy, SLAM, SAP, XLP, costimulatory molecules
Abstract: The generation of an allergic immune response requires at least two signals for complete activation of T cells. Costimulatory molecules are integral to the second signal. In this review, we analyze the costimulatory molecule signaling lymphocytic activation molecule (SLAM) and other recently described SLAM family members. We highlight recent findings that position SLAM as critical for allergic inflammation and its role in modulation of cytokine secretion. Furthermore, a possible role of SLAM as a link between the adaptive and innate immune response is also discussed. Understanding the role of costimulatory molecules, including SLAM and SLAM family members, may elucidate mechanisms involved in the allergic immune response, and suggest potential therapeutic opportunities.
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Cite this article as:
Makani S. Samir, Jen Y. Kai and Finn W. Patricia, New Costimulatory Families: Signaling Lymphocytic Activation Molecule in Adaptive Allergic Responses, Current Molecular Medicine 2008; 8 (5) . https://dx.doi.org/10.2174/156652408785161005
DOI https://dx.doi.org/10.2174/156652408785161005 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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