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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Potential Indicators of Mitochondrial Structure and Function

Author(s): Xu-Dong He, Fan Zhang, Ying Huang, Jun-Jie Hao, Mei Zhang, Jin-Biao He, Xue-Mei Pu, Yan-Juan Li, Lei Zi, Jie Yu* and Xing-Xin Yang*

Volume 28, Issue 21, 2022

Published on: 24 June, 2022

Page: [1738 - 1744] Pages: 7

DOI: 10.2174/1381612828666220520161200

Price: $65

Abstract

Mitochondria regulate a range of important physiological and biochemical cellular processes including apoptotic cell death, energy production, calcium homeostasis, oxidative stress, and lipid metabolism. Given their role as the ‘engines’ of cells, their dysfunction is associated with a variety of disease states. Exploring the relationship between mitochondrial function and disease can reveal the mechanism(s) of drug activity and disease pathology. In this review, we summarized the methods of evaluating the structure and function of mitochondria, including the morphology, membrane fluidity, membrane potential, opening of the membrane permeability transition pore, inner membrane permeabilization, mitochondrial dynamics, mitophagy, oxidative stress, energy metabolism-related enzymes, apoptotic pathway related proteins, calcium concentration, DNA copy number, oxygen consumption, β-oxidation-related genes and proteins, cardiolipin content, and adenosine triphosphate content. We believe that the information presented in this review will help explore the pathological processes of mitochondria in the occurrence and development of diseases, as well as the activity and mechanism of drugs, and the discovery of new drugs.

Keywords: Disease, mechanism, drug, evaluation, method, mitochondria.

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