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Current Genomics


ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Review Article

Etiopathogenesis of Psoriasis from Genetic Perspective: An updated Review

Author(s): Farhad Babaie, Melodi Omraninava, Armita Mahdavi Gorabi, Arezou Khosrojerdi, Saeed Aslani, Arsalan Yazdchi, Shahram Torkamandi*, Haleh Mikaeili*, Thozhukat Sathyapalan and Amirhossein Sahebkar*

Volume 23, Issue 3, 2022

Published on: 09 June, 2022

Page: [163 - 174] Pages: 12

DOI: 10.2174/1389202923666220527111037

Price: $65


Psoriasis is an organ-specific autoimmune disease characterized by the aberrant proliferation and differentiation of keratinocytes, leading to skin lesions. Abnormal immune responses mediated by T cells and dendritic cells and increased production of inflammatory cytokines have been suggested as underlying mechanisms in the pathogenesis of psoriasis. Emerging evidence suggests that there is a heritable basis for psoriatic disorders. Moreover, numerous gene variations have been associated with the disease risk, particularly those in innate and adaptive immune responses and antigen presentation pathways. Herein, this article discusses the genetic implications of psoriatic diseases' etiopathogenesis to develop novel investigative and management options.

Keywords: Genetics, immune response, autoimmunity, psoriasis, etiopathogenesis, keratinocytes.

Graphical Abstract
Chandran, V.; Raychaudhuri, S.P. Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis. J. Autoimmun., 2010, 34(3), J314-J321.
[] [PMID: 20034760]
Lowes, M.A.; Russell, C.B.; Martin, D.A.; Towne, J.E.; Krueger, J.G. The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses. Trends Immunol., 2013, 34(4), 174-181.
[] [PMID: 23291100]
Mak, R.; Hundhausen, C.; Nestle, F. Progress in understanding the immunopathogenesis of psoriasis. Actas Dermo-Sifiliograficas., 2009, 100, 2-13.
Nickoloff, B.J.; Nestle, F.O. Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities. J. Clin. Invest., 2004, 113(12), 1664-1675.
[] [PMID: 15199399]
Zhou, X.; Chen, Y.; Cui, L.; Shi, Y.; Guo, C. Advances in the pathogenesis of psoriasis: From keratinocyte perspective. Cell Death Dis., 2022, 13(1), 81.
[] [PMID: 35075118]
Mahil, S.K.; Capon, F.; Barker, J.N. Genetics of psoriasis. Dermatol. Clin., 2015, 33(1), 1-11.
[] [PMID: 25412779]
Gao, J.; Shen, X.; Ko, R.; Huang, C.; Shen, C. Cognitive process of psoriasis and its comorbidities: From epidemiology to genetics. Front. Genet., 2021, 12, 735124.
[] [PMID: 34899832]
Huang, Y-H.; Kuo, C-F.; Huang, L-H.; Hsieh, M-Y. Familial aggregation of psoriasis and co-aggregation of autoimmune diseases in affected families. J. Clin. Med., 2019, 8(1), 115.
[] [PMID: 30669308]
Je, G. Elder Jt Psoriasis: Epidemiology. Clinics in Dermatology, 2007.
Brandrup, F.; Holm, N.; Grunnet, N.; Henningsen, K.; Hansen, H.E. Psoriasis in monozygotic twins: Variations in expression in individuals with identical genetic constitution. Acta Derm. Venereol., 1982, 62(3), 229-236.
[PMID: 6179364]
Farber, E.M.; Nall, M.L.; Watson, W. Natural history of psoriasis in 61 twin pairs. Arch. Dermatol., 1974, 109(2), 207-211.
[] [PMID: 4814926]
Lønnberg, A.S.; Skov, L.; Skytthe, A.; Kyvik, K.O.; Pedersen, O.B.; Thomsen, S.F. Heritability of psoriasis in a large twin sample. Br. J. Dermatol., 2013, 169(2), 412-416.
[] [PMID: 23574549]
Grjibovski, A.M.; Olsen, A.O.; Magnus, P.; Harris, J.R. Psoriasis in Norwegian twins: Contribution of genetic and environmental effects. J. Eur. Acad. Dermatol. Venereol., 2007, 21(10), 1337-1343.
[] [PMID: 17958839]
O’Rielly, D.D.; Rahman, P. Genetics of susceptibility and treatment response in psoriatic arthritis. Nat. Rev. Rheumatol., 2011, 7(12), 718-732.
[] [PMID: 22064628]
Karason, A.; Gudjonsson, J.E.; Upmanyu, R.; Antonsdottir, A.A.; Hauksson, V.B.; Runasdottir, E.H.; Jonsson, H.H.; Gudbjartsson, D.F.; Frigge, M.L.; Kong, A.; Stefansson, K.; Valdimarsson, H.; Gulcher, J.R. A susceptibility gene for psoriatic arthritis maps to chromosome 16q: Evidence for imprinting. Am. J. Hum. Genet., 2003, 72(1), 125-131.
[] [PMID: 12474146]
Nair, R.P.; Duffin, K.C.; Helms, C.; Ding, J.; Stuart, P.E.; Goldgar, D.; Gudjonsson, J.E.; Li, Y.; Tejasvi, T.; Feng, B.J.; Ruether, A.; Schreiber, S.; Weichenthal, M.; Gladman, D.; Rahman, P.; Schrodi, S.J.; Prahalad, S.; Guthery, S.L.; Fischer, J.; Liao, W.; Kwok, P.Y.; Menter, A.; Lathrop, G.M.; Wise, C.A.; Begovich, A.B.; Voorhees, J.J.; Elder, J.T.; Krueger, G.G.; Bowcock, A.M.; Abecasis, G.R. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat. Genet., 2009, 41(2), 199-204.
[] [PMID: 19169254]
Strange, A.; Capon, F.; Spencer, C.C.; Knight, J.; Weale, M.E.; Allen, M.H.; Barton, A.; Band, G.; Bellenguez, C.; Bergboer, J.G.; Blackwell, J.M.; Bramon, E.; Bumpstead, S.J.; Casas, J.P.; Cork, M.J.; Corvin, A.; Deloukas, P.; Dilthey, A.; Duncanson, A.; Edkins, S.; Estivill, X.; Fitzgerald, O.; Freeman, C.; Giardina, E.; Gray, E.; Hofer, A.; Hüffmeier, U.; Hunt, S.E.; Irvine, A.D.; Jankowski, J.; Kirby, B.; Langford, C.; Lascorz, J.; Leman, J.; Leslie, S.; Mallbris, L.; Markus, H.S.; Mathew, C.G.; McLean, W.H.; McManus, R.; Mössner, R.; Moutsianas, L.; Naluai, A.T.; Nestle, F.O.; Novelli, G.; Onoufriadis, A.; Palmer, C.N.; Perricone, C.; Pirinen, M.; Plomin, R.; Potter, S.C.; Pujol, R.M.; Rautanen, A.; Riveira-Munoz, E.; Ryan, A.W.; Salmhofer, W.; Samuelsson, L.; Sawcer, S.J.; Schalkwijk, J.; Smith, C.H.; Ståhle, M.; Su, Z.; Tazi-Ahnini, R.; Traupe, H.; Viswanathan, A.C.; Warren, R.B.; Weger, W.; Wolk, K.; Wood, N.; Worthington, J.; Young, H.S.; Zeeuwen, P.L.; Hayday, A.; Burden, A.D.; Griffiths, C.E.; Kere, J.; Reis, A.; McVean, G.; Evans, D.M.; Brown, M.A.; Barker, J.N.; Peltonen, L.; Donnelly, P.; Trembath, R.C. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat. Genet., 2010, 42(11), 985-990.
[] [PMID: 20953190]
Liu, Y.; Helms, C.; Liao, W.; Zaba, L.C.; Duan, S.; Gardner, J.; Wise, C.; Miner, A.; Malloy, M.J.; Pullinger, C.R.; Kane, J.P.; Saccone, S.; Worthington, J.; Bruce, I.; Kwok, P.Y.; Menter, A.; Krueger, J.; Barton, A.; Saccone, N.L.; Bowcock, A.M. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet., 2008, 4(3), e1000041.
[] [PMID: 18369459]
Nair, R.P.; Stuart, P.E.; Nistor, I.; Hiremagalore, R.; Chia, N.V.C.; Jenisch, S.; Weichenthal, M.; Abecasis, G.R.; Lim, H.W.; Christophers, E.; Voorhees, J.J.; Elder, J.T. Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am. J. Hum. Genet., 2006, 78(5), 827-851.
[] [PMID: 16642438]
Eder, L.; Chandran, V.; Pellett, F.; Shanmugarajah, S.; Rosen, C.F.; Bull, S.B.; Gladman, D.D. Differential human leucocyte allele association between psoriasis and psoriatic arthritis: A family-based association study. Ann. Rheum. Dis., 2012, 71(8), 1361-1365.
[] [PMID: 22586163]
Chen, L.; Tsai, T.F. HLA-Cw6 and psoriasis. Br. J. Dermatol., 2018, 178(4), 854-862.
[] [PMID: 29072309]
Gudjonsson, J.E.; Karason, A.; Runarsdottir, E.H.; Antonsdottir, A.A.; Hauksson, V.B.; Jónsson, H.H.; Gulcher, J.; Stefansson, K.; Valdimarsson, H. Distinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patients--an analysis of 1019 HLA-C- and HLA-B-typed patients. J. Invest. Dermatol., 2006, 126(4), 740-745.
[] [PMID: 16439971]
Eder, L.; Chandran, V.; Gladman, D.D. What have we learned about genetic susceptibility in psoriasis and psoriatic arthritis? Curr. Opin. Rheumatol., 2015, 27(1), 91-98.
[] [PMID: 25415529]
Temel, B.; Adisen, E.; Gonen, S. HLA-Cw6 status and treatment responses between psoriasis patients. Indian J. Dermatol., 2021, 66(6), 632-637.
[] [PMID: 35283491]
Hirata, J.; Hirota, T.; Ozeki, T.; Kanai, M.; Sudo, T.; Tanaka, T.; Hizawa, N.; Nakagawa, H.; Sato, S.; Mushiroda, T.; Saeki, H.; Tamari, M.; Okada, Y. Variants at HLA-A, HLA-C, and HLA-DQB1 confer risk of psoriasis vulgaris in Japanese. J. Invest. Dermatol., 2018, 138(3), 542-548.
[] [PMID: 29031612]
Winchester, R.; Minevich, G.; Steshenko, V.; Kirby, B.; Kane, D.; Greenberg, D.A.; FitzGerald, O. HLA associations reveal genetic heterogeneity in psoriatic arthritis and in the psoriasis phenotype. Arthritis Rheum., 2012, 64(4), 1134-1144.
[] [PMID: 22006066]
Haroon, M.; Winchester, R.; Giles, J.T.; Heffernan, E.; FitzGerald, O. Certain class I HLA alleles and haplotypes implicated in susceptibility play a role in determining specific features of the psoriatic arthritis phenotype. Ann. Rheum. Dis., 2014, 75(1), 155-162.
Eder, L.; Chandran, V.; Pellet, F.; Shanmugarajah, S.; Rosen, C.F.; Bull, S.B.; Gladman, D.D. Human leucocyte antigen risk alleles for psoriatic arthritis among patients with psoriasis. Ann. Rheum. Dis., 2012, 71(1), 50-55.
[] [PMID: 21900282]
Okada, Y.; Han, B.; Tsoi, L.C.; Stuart, P.E.; Ellinghaus, E.; Tejasvi, T.; Chandran, V.; Pellett, F.; Pollock, R.; Bowcock, A.M.; Krueger, G.G.; Weichenthal, M.; Voorhees, J.J.; Rahman, P.; Gregersen, P.K.; Franke, A.; Nair, R.P.; Abecasis, G.R.; Gladman, D.D.; Elder, J.T.; de Bakker, P.I.; Raychaudhuri, S. Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes. Am. J. Hum. Genet., 2014, 95(2), 162-172.
[] [PMID: 25087609]
Gonzalez, S.; Martinez-Borra, J.; Torre-Alonso, J.C.; Gonzalez-Roces, S.; Sanchez del Río, J.; Rodriguez Pérez, A.; Brautbar, C.; López-Larrea, C. The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis. Arthritis Rheum., 1999, 42(5), 1010-1016.
[<1010:AID-ANR21>3.0.CO;2-H] [PMID: 10323458]
Lanier, L.L. NK cell recognition. Annu. Rev. Immunol., 2005, 23, 225-274.
[] [PMID: 15771571]
Mahmoudi, M.; Jamshidi, A.R.; Karami, J.; Mohseni, A.; Amirzargar, A.A.; Farhadi, E.; Ahmadzadeh, N.; Nicknam, M.H. Analysis of killer cell immunoglobulin-like receptor genes and their HLA ligands in Iranian patients with ankylosing spondylitis. Iran. J. Allergy Asthma Immunol., 2016, 15(1), 27-38.
[PMID: 26996109]
Mahmoudi, M.; Fallahian, F.; Sobhani, S.; Ghoroghi, S.; Jamshidi, A.; Poursani, S.; Dolati, M.; Hosseinpour, Z.; Gharibdoost, F. Analysis of killer cell immunoglobulin-like receptors (KIRs) and their HLA ligand genes polymorphisms in Iranian patients with systemic sclerosis. Clin. Rheumatol., 2017, 36(4), 853-862.
[] [PMID: 28120169]
Nazari, M.; Mahmoudi, M.; Rahmani, F.; Akhlaghi, M.; Beigy, M.; Azarian, M.; Shamsian, E.; Akhtari, M.; Mansouri, R. Association of killer cell immunoglobulin-like receptor genes in iranian patients with rheumatoid arthritis. PLoS One, 2015, 10(12), e0143757.
[] [PMID: 26658904]
Dastmalchi, R.; Farazmand, A.; Noshad, S.; Mozafari, M.; Mahmoudi, M.; Esteghamati, A.; Amirzargar, A. Polymorphism of killer cell immunoglobulin-like receptors (KIR) and their HLA ligands in Graves’ disease. Mol. Biol. Rep., 2014, 41(8), 5367-5374.
[] [PMID: 24852304]
Chandran, V.; Bull, S.B.; Pellett, F.J.; Ayearst, R.; Pollock, R.A.; Gladman, D.D. Killer-cell immunoglobulin-like receptor gene polymorphisms and susceptibility to psoriatic arthritis. Rheumatology (Oxford), 2014, 53(2), 233-239.
[] [PMID: 24185760]
Schröder, J-M.; Harder, J. Human beta-defensin-2. Int. J. Biochem. Cell Biol., 1999, 31(6), 645-651.
[] [PMID: 10404637]
Hollox, E.J.; Huffmeier, U.; Zeeuwen, P.L.; Palla, R.; Lascorz, J.; Rodijk-Olthuis, D.; van de Kerkhof, P.C.; Traupe, H.; de Jongh, G.; den Heijer, M.; Reis, A.; Armour, J.A.; Schalkwijk, J. Psoriasis is associated with increased β-defensin genomic copy number. Nat. Genet., 2008, 40(1), 23-25.
[] [PMID: 18059266]
Niyonsaba, F.; Ogawa, H.; Nagaoka, I. Human β-defensin-2 functions as a chemotactic agent for tumour necrosis factor-α-treated human neutrophils. Immunology, 2004, 111(3), 273-281.
[] [PMID: 15009427]
Filer, C.; Ho, P.; Smith, R.L.; Griffiths, C.; Young, H.S.; Worthington, J.; Bruce, I.N.; Barton, A. Investigation of association of the IL12B and IL23R genes with psoriatic arthritis. Arthritis Rheum., 2008, 58(12), 3705-3709.
[] [PMID: 19035472]
Li, M.; Wu, Y.; Chen, G.; Yang, Y.; Zhou, D.; Zhang, Z.; Zhang, D.; Chen, Y.; Lu, Z.; He, L.; Zheng, J.; Liu, Y. Deletion of the late cornified envelope genes LCE3C and LCE3B is associated with psoriasis in a Chinese population. J. Invest. Dermatol., 2011, 131(8), 1639-1643.
[] [PMID: 21509048]
Coto, E.; Santos-Juanes, J.; Coto-Segura, P.; Díaz, M.; Soto, J.; Queiro, R.; Alvarez, V. Mutation analysis of the LCE3B/LCE3C genes in Psoriasis. BMC Med. Genet., 2010, 11(1), 45.
[] [PMID: 20331852]
Riveira-Munoz, E.; He, S-M.; Escaramís, G.; Stuart, P.E.; Hüffmeier, U.; Lee, C.; Kirby, B.; Oka, A.; Giardina, E.; Liao, W.; Bergboer, J.; Kainu, K.; de Cid, R.; Munkhbat, B.; Zeeuwen, P.L.; Armour, J.A.; Poon, A.; Mabuchi, T.; Ozawa, A.; Zawirska, A.; Burden, A.D.; Barker, J.N.; Capon, F.; Traupe, H.; Sun, L.D.; Cui, Y.; Yin, X.Y.; Chen, G.; Lim, H.W.; Nair, R.P.; Voorhees, J.J.; Tejasvi, T.; Pujol, R.; Munkhtuvshin, N.; Fischer, J.; Kere, J.; Schalkwijk, J.; Bowcock, A.; Kwok, P.Y.; Novelli, G.; Inoko, H.; Ryan, A.W.; Trembath, R.C.; Reis, A.; Zhang, X.J.; Elder, J.T.; Estivill, X. Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6. J. Invest. Dermatol., 2011, 131(5), 1105-1109.
[] [PMID: 21107349]
Labarthe, M-P.; Bosco, D.; Saurat, J.H.; Meda, P.; Salomon, D. Upregulation of connexin 26 between keratinocytes of psoriatic lesions. J. Invest. Dermatol., 1998, 111(1), 72-76.
[] [PMID: 9665389]
Djalilian, A.R.; McGaughey, D.; Patel, S.; Seo, E.Y.; Yang, C.; Cheng, J.; Tomic, M.; Sinha, S.; Ishida-Yamamoto, A.; Segre, J.A. Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. J. Clin. Invest., 2006, 116(5), 1243-1253.
[] [PMID: 16628254]
Sun, L-D.; Cheng, H.; Wang, Z-X.; Zhang, A-P.; Wang, P-G.; Xu, J-H.; Zhu, Q.X.; Zhou, H.S.; Ellinghaus, E.; Zhang, F.R.; Pu, X.M.; Yang, X.Q.; Zhang, J.Z.; Xu, A.E.; Wu, R.N.; Xu, L.M.; Peng, L.; Helms, C.A.; Ren, Y.Q.; Zhang, C.; Zhang, S.M.; Nair, R.P.; Wang, H.Y.; Lin, G.S.; Stuart, P.E.; Fan, X.; Chen, G.; Tejasvi, T.; Li, P.; Zhu, J.; Li, Z.M.; Ge, H.M.; Weichenthal, M.; Ye, W.Z.; Zhang, C.; Shen, S.K.; Yang, B.Q.; Sun, Y.Y.; Li, S.S.; Lin, Y.; Jiang, J.H.; Li, C.T.; Chen, R.X.; Cheng, J.; Jiang, X.; Zhang, P.; Song, W.M.; Tang, J.; Zhang, H.Q.; Sun, L.; Cui, J.; Zhang, L.J.; Tang, B.; Huang, F.; Qin, Q.; Pei, X.P.; Zhou, A.M.; Shao, L.M.; Liu, J.L.; Zhang, F.Y.; Du, W.D.; Franke, A.; Bowcock, A.M.; Elder, J.T.; Liu, J.J.; Yang, S.; Zhang, X.J. Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nat. Genet., 2010, 42(11), 1005-1009.
[] [PMID: 20953187]
Hüffmeier, U.; Uebe, S.; Ekici, A.B.; Bowes, J.; Giardina, E.; Korendowych, E.; Juneblad, K.; Apel, M.; McManus, R.; Ho, P.; Bruce, I.N.; Ryan, A.W.; Behrens, F.; Lascorz, J.; Böhm, B.; Traupe, H.; Lohmann, J.; Gieger, C.; Wichmann, H.E.; Herold, C.; Steffens, M.; Klareskog, L.; Wienker, T.F.; Fitzgerald, O.; Alenius, G.M.; McHugh, N.J.; Novelli, G.; Burkhardt, H.; Barton, A.; Reis, A. Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. Nat. Genet., 2010, 42(11), 996-999.
[] [PMID: 20953186]
Tsoi, L.C.; Spain, S.L.; Knight, J.; Ellinghaus, E.; Stuart, P.E.; Capon, F.; Ding, J.; Li, Y.; Tejasvi, T.; Gudjonsson, J.E.; Kang, H.M.; Allen, M.H.; McManus, R.; Novelli, G.; Samuelsson, L.; Schalkwijk, J.; Ståhle, M.; Burden, A.D.; Smith, C.H.; Cork, M.J.; Estivill, X.; Bowcock, A.M.; Krueger, G.G.; Weger, W.; Worthington, J.; Tazi-Ahnini, R.; Nestle, F.O.; Hayday, A.; Hoffmann, P.; Winkelmann, J.; Wijmenga, C.; Langford, C.; Edkins, S.; Andrews, R.; Blackburn, H.; Strange, A.; Band, G.; Pearson, R.D.; Vukcevic, D.; Spencer, C.C.; Deloukas, P.; Mrowietz, U.; Schreiber, S.; Weidinger, S.; Koks, S.; Kingo, K.; Esko, T.; Metspalu, A.; Lim, H.W.; Voorhees, J.J.; Weichenthal, M.; Wichmann, H.E.; Chandran, V.; Rosen, C.F.; Rahman, P.; Gladman, D.D.; Griffiths, C.E.; Reis, A.; Kere, J.; Nair, R.P.; Franke, A.; Barker, J.N.; Abecasis, G.R.; Elder, J.T.; Trembath, R.C. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat. Genet., 2012, 44(12), 1341-1348.
[] [PMID: 23143594]
Ellinghaus, D.; Ellinghaus, E.; Nair, R.P.; Stuart, P.E.; Esko, T.; Metspalu, A.; Debrus, S.; Raelson, J.V.; Tejasvi, T.; Belouchi, M.; West, S.L.; Barker, J.N.; Kõks, S.; Kingo, K.; Balschun, T.; Palmieri, O.; Annese, V.; Gieger, C.; Wichmann, H.E.; Kabesch, M.; Trembath, R.C.; Mathew, C.G.; Abecasis, G.R.; Weidinger, S.; Nikolaus, S.; Schreiber, S.; Elder, J.T.; Weichenthal, M.; Nothnagel, M.; Franke, A. Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. Am. J. Hum. Genet., 2012, 90(4), 636-647.
[] [PMID: 22482804]
Stuart, P.E.; Nair, R.P.; Ellinghaus, E.; Ding, J.; Tejasvi, T.; Gudjonsson, J.E.; Li, Y.; Weidinger, S.; Eberlein, B.; Gieger, C.; Wichmann, H.E.; Kunz, M.; Ike, R.; Krueger, G.G.; Bowcock, A.M.; Mrowietz, U.; Lim, H.W.; Voorhees, J.J.; Abecasis, G.R.; Weichenthal, M.; Franke, A.; Rahman, P.; Gladman, D.D.; Elder, J.T. Genome-wide association analysis identifies three psoriasis susceptibility loci. Nat. Genet., 2010, 42(11), 1000-1004.
[] [PMID: 20953189]
Ellinghaus, E.; Ellinghaus, D.; Stuart, P.E.; Nair, R.P.; Debrus, S.; Raelson, J.V.; Belouchi, M.; Fournier, H.; Reinhard, C.; Ding, J.; Li, Y.; Tejasvi, T.; Gudjonsson, J.; Stoll, S.W.; Voorhees, J.J.; Lambert, S.; Weidinger, S.; Eberlein, B.; Kunz, M.; Rahman, P.; Gladman, D.D.; Gieger, C.; Wichmann, H.E.; Karlsen, T.H.; Mayr, G.; Albrecht, M.; Kabelitz, D.; Mrowietz, U.; Abecasis, G.R.; Elder, J.T.; Schreiber, S.; Weichenthal, M.; Franke, A. Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat. Genet., 2010, 42(11), 991-995.
[] [PMID: 20953188]
Zhang, X-J.; Huang, W.; Yang, S.; Sun, L-D.; Zhang, F-Y.; Zhu, Q-X.; Zhang, F.R.; Zhang, C.; Du, W.H.; Pu, X.M.; Li, H.; Xiao, F.L.; Wang, Z.X.; Cui, Y.; Hao, F.; Zheng, J.; Yang, X.Q.; Cheng, H.; He, C.D.; Liu, X.M.; Xu, L.M.; Zheng, H.F.; Zhang, S.M.; Zhang, J.Z.; Wang, H.Y.; Cheng, Y.L.; Ji, B.H.; Fang, Q.Y.; Li, Y.Z.; Zhou, F.S.; Han, J.W.; Quan, C.; Chen, B.; Liu, J.L.; Lin, D.; Fan, L.; Zhang, A.P.; Liu, S.X.; Yang, C.J.; Wang, P.G.; Zhou, W.M.; Lin, G.S.; Wu, W.D.; Fan, X.; Gao, M.; Yang, B.Q.; Lu, W.S.; Zhang, Z.; Zhu, K.J.; Shen, S.K.; Li, M.; Zhang, X.Y.; Cao, T.T.; Ren, W.; Zhang, X.; He, J.; Tang, X.F.; Lu, S.; Yang, J.Q.; Zhang, L.; Wang, D.N.; Yuan, F.; Yin, X.Y.; Huang, H.J.; Wang, H.F.; Lin, X.Y.; Liu, J.J. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat. Genet., 2009, 41(2), 205-210.
[] [PMID: 19169255]
Orozco, G.; Eyre, S.; Hinks, A.; Bowes, J.; Morgan, A.W.; Wilson, A.G.; Wordsworth, P.; Steer, S.; Hocking, L.; Thomson, W.; Worthington, J.; Barton, A. Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus. Ann. Rheum. Dis., 2011, 70(3), 463-468.
[] [PMID: 21068098]
Nititham, J.; Taylor, K.E.; Gupta, R.; Chen, H.; Ahn, R.; Liu, J.; Seielstad, M.; Ma, A.; Bowcock, A.M.; Criswell, L.A.; Stahle, M.; Liao, W. Meta-analysis of the TNFAIP3 region in psoriasis reveals a risk haplotype that is distinct from other autoimmune diseases. Genes Immun., 2015, 16(2), 120-126.
[] [PMID: 25521225]
Shi, G.; Cheng, C.; Wang, T.; Li, S.; Fan, Y.; Zhu, K. Association between atopic dermatitis-related single nucleotide polymorphisms rs4722404 and psoriasis vulgaris in a southern Chinese cohort. Genet. Mol. Res., 2016, 15(2), 15028356.
Feng, C.; Wang, T.; Li, S.J.; Fan, Y.M.; Shi, G.; Zhu, K.J. CARD14 gene polymorphism c.C2458T (p.Arg820Trp) is associated with clinical features of psoriasis vulgaris in a Chinese cohort. J. Dermatol., 2016, 43(3), 294-297.
[] [PMID: 26249641]
Shi, G.; Zhang, M.; Liao, P.; Wang, T.; Li, S.; Fan, Y. Lack of association between CARD10/CARMA3 tag SNPs and psoriasis vulgaris in the southern Chinese population. Genet. Mol. Res., 2017, 16(1), 16019025.
Budu-Aggrey, A.; Bowes, J.; Stuart, P.E.; Zawistowski, M.; Tsoi, L.C.; Nair, R.; Jadon, D.R.; McHugh, N.; Korendowych, E.; Elder, J.T.; Barton, A.; Raychaudhuri, S. A rare coding allele in IFIH1 is protective for psoriatic arthritis. Ann. Rheum. Dis., 2017, 76(7), 1321-1324.
[] [PMID: 28501801]
Gotoh, K.; Tanaka, Y.; Nishikimi, A.; Nakamura, R.; Yamada, H.; Maeda, N.; Ishikawa, T.; Hoshino, K.; Uruno, T.; Cao, Q.; Higashi, S.; Kawaguchi, Y.; Enjoji, M.; Takayanagi, R.; Kaisho, T.; Yoshikai, Y.; Fukui, Y. Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation. J. Exp. Med., 2010, 207(4), 721-730.
[] [PMID: 20231379]
Zhou, Z.; Hamming, O.J.; Ank, N.; Paludan, S.R.; Nielsen, A.L.; Hartmann, R. Type III interferon (IFN) induces a type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinases. J. Virol., 2007, 81(14), 7749-7758.
[] [PMID: 17507495]
Piganis, R.A.; De Weerd, N.A.; Gould, J.A.; Schindler, C.W.; Mansell, A.; Nicholson, S.E.; Hertzog, P.J. Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon α receptor (IFNAR1)-associated tyrosine kinase Tyk2. J. Biol. Chem., 2011, 286(39), 33811-33818.
[] [PMID: 21757742]
Negishi, H.; Osawa, T.; Ogami, K.; Ouyang, X.; Sakaguchi, S.; Koshiba, R.; Yanai, H.; Seko, Y.; Shitara, H.; Bishop, K.; Yonekawa, H.; Tamura, T.; Kaisho, T.; Taya, C.; Taniguchi, T.; Honda, K. A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Proc. Natl. Acad. Sci. USA, 2008, 105(51), 20446-20451.
[] [PMID: 19074283]
Bijlmakers, M-J.; Kanneganti, S.K.; Barker, J.N.; Trembath, R.C.; Capon, F. Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double-stranded RNA in disease pathogenesis. Hum. Mol. Genet., 2011, 20(16), 3129-3137.
[] [PMID: 21571784]
Veale, D.J.; Barnes, L.; Rogers, S.; FitzGerald, O. Immunohistochemical markers for arthritis in psoriasis. Ann. Rheum. Dis., 1994, 53(7), 450-454.
[] [PMID: 7944617]
Pitzalis, C.; Cauli, A.; Pipitone, N.; Smith, C.; Barker, J.; Marchesoni, A.; Yanni, G.; Panayi, G.S. Cutaneous lymphocyte antigen-positive T lymphocytes preferentially migrate to the skin but not to the joint in psoriatic arthritis. Arthritis Rheum., 1996, 39(1), 137-145.
[] [PMID: 8546722]
Miossec, P. IL-17 and Th17 cells in human inflammatory diseases. Microbes Infect., 2009, 11(5), 625-630.
[] [PMID: 19371791]
Bowcock, A.M.; Shannon, W.; Du, F.; Duncan, J.; Cao, K.; Aftergut, K.; Catier, J.; Fernandez-Vina, M.A.; Menter, A. Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies. Hum. Mol. Genet., 2001, 10(17), 1793-1805.
[] [PMID: 11532989]
Kersh, E.N. Impaired memory CD8 T cell development in the absence of methyl-CpG-binding domain protein 2. J. Immunol., 2006, 177(6), 3821-3826.
[] [PMID: 16951344]
Zamisch, M.; Tian, L.; Grenningloh, R.; Xiong, Y.; Wildt, K.F.; Ehlers, M.; Ho, I.C.; Bosselut, R. The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus. J. Exp. Med., 2009, 206(12), 2685-2699.
[] [PMID: 19917777]
Chang, I-F.; Hsiao, H-Y. Induction of RhoGAP and pathological changes characteristic of Alzheimer’s disease by UAHFEMF discharge in rat brain. Curr. Alzheimer Res., 2005, 2(5), 559-569.
[] [PMID: 16375659]
Togayachi, A. Kozono, Y.; Kuno, A.; Ohkura, T.; Sato, T.; Hirabayashi, J.; Ikehara, Y.; Narimatsu, H. β3GnT2 (B3GNT2), a major polylactosamine synthase: Analysis of B3GNT2-deficient mice. Methods Enzymol., 2010, 479, 185-204.
[] [PMID: 20816167]
Yan, J.; Parekh, V.V.; Mendez-Fernandez, Y.; Olivares-Villagómez, D.; Dragovic, S.; Hill, T.; Roopenian, D.C.; Joyce, S.; Van Kaer, L. In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. J. Exp. Med., 2006, 203(3), 647-659.
[] [PMID: 16505142]
Ryan, C.; Abramson, A.; Patel, M.; Menter, A. Current investigational drugs in psoriasis. Expert Opin. Investig. Drugs, 2012, 21(4), 473-487.
[] [PMID: 22400979]
Robinson, R.T. IL12Rβ1: The cytokine receptor that we used to know. Cytokine, 2015, 71(2), 348-359.
[] [PMID: 25516297]
Liang, J.; Wang, J.; Azfer, A.; Song, W.; Tromp, G.; Kolattukudy, P.E.; Fu, M. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. J. Biol. Chem., 2008, 283(10), 6337-6346.
[] [PMID: 18178554]
Wei, L.; Laurence, A.; O’Shea, J.J. New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation. Seminars in cell & developmental biology; Elsevier, 2008.
Marcoulatos, P.; Avgerinos, E.; Tsantzalos, D.V.; Vamvakopoulos, N.C. Mapping interleukin enhancer binding factor 3 gene (ILF3) to human chromosome 19 (19q11-qter and 19p11-p13.1) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates. J. Interferon Cytokine Res., 1998, 18(5), 351-355.
[] [PMID: 9620363]
Cheung, P.F.; Wong, C.K.; Lam, C.W. Molecular mechanisms of cytokine and chemokine release from eosinophils activated by IL-17A, IL-17F, and IL-23: Implication for Th17 lymphocytes-mediated allergic inflammation. J. Immunol., 2008, 180(8), 5625-5635.
[] [PMID: 18390747]
Bulek, K.; Liu, C.; Swaidani, S.; Wang, L.; Page, R.C.; Gulen, M.F.; Herjan, T.; Abbadi, A.; Qian, W.; Sun, D.; Lauer, M.; Hascall, V.; Misra, S.; Chance, M.R.; Aronica, M.; Hamilton, T.; Li, X. The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation. Nat. Immunol., 2011, 12(9), 844-852.
[] [PMID: 21822257]
Sønder, S.U.; Saret, S.; Tang, W.; Sturdevant, D.E.; Porcella, S.F.; Siebenlist, U. IL-17-induced NF-kappaB activation via CIKS/Act1: Physiologic significance and signaling mechanisms. J. Biol. Chem., 2011, 286(15), 12881-12890.
[] [PMID: 21335551]
Fujioka, S.; Niu, J.; Schmidt, C.; Sclabas, G.M.; Peng, B.; Uwagawa, T.; Li, Z.; Evans, D.B.; Abbruzzese, J.L.; Chiao, P.J. NF-kappaB and AP-1 connection: Mechanism of NF-kappaB-dependent regulation of AP-1 activity. Mol. Cell. Biol., 2004, 24(17), 7806-7819.
[] [PMID: 15314185]
Chiricozzi, A.; Guttman-Yassky, E.; Suárez-Fariñas, M.; Nograles, K.E.; Tian, S.; Cardinale, I.; Chimenti, S.; Krueger, J.G. Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis. J. Invest. Dermatol., 2011, 131(3), 677-687.
[] [PMID: 21085185]
Ten Bergen, L.L.; Petrovic, A.; Krogh Aarebrot, A.; Appel, S. The TNF/IL-23/IL-17 axis-Head-to-head trials comparing different biologics in psoriasis treatment. Scand. J. Immunol., 2020, 92(4), e12946.
[] [PMID: 32697374]
Flisiak, I.; Chodynicka, B.; Porebski, P.; Flisiak, R. Association between psoriasis severity and transforming growth factor β(1) and β (2) in plasma and scales from psoriatic lesions. Cytokine, 2002, 19(3), 121-125.
[] [PMID: 12242078]
Flisiak, I.; Zaniewski, P.; Chodynicka, B. Plasma TGF-β1, TIMP-1, MMP-1 and IL-18 as a combined biomarker of psoriasis activity. Biomarkers, 2008, 13(5), 549-556.
[] [PMID: 18979644]
Nockowski, P.; Szepietowski, J.C.; Ziarkiewicz, M.; Baran, E. Serum concentrations of transforming growth factor beta 1 in patients with psoriasis vulgaris. Acta Dermatovenerol. Croat., 2004, 12(1), 2-6.
[PMID: 15072741]
Lindroos, J.; Svensson, L.; Norsgaard, H.; Lovato, P.; Moller, K.; Hagedorn, P.H.; Olsen, G.M.; Labuda, T. IL-23-mediated epidermal hyperplasia is dependent on IL-6. J. Invest. Dermatol., 2011, 131(5), 1110-1118.
[] [PMID: 21289639]
Yang, X-P.; Ghoreschi, K.; Steward-Tharp, S.M.; Rodriguez-Canales, J.; Zhu, J.; Grainger, J.R.; Hirahara, K.; Sun, H.W.; Wei, L.; Vahedi, G.; Kanno, Y.; O’Shea, J.J.; Laurence, A. Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat. Immunol., 2011, 12(3), 247-254.
[] [PMID: 21278738]
Boca, A.N.; Talamonti, M.; Galluzzo, M.; Botti, E. Vesa, Ş.C.; Chimenti, S.; Buzoianu, A.D.; Costanzo, A. Genetic variations in IL6 and IL12B decreasing the risk for psoriasis. Immunol. Lett., 2013, 156(1-2), 127-131.
[] [PMID: 24140476]
Di Cesare, A.; Di Meglio, P.; Nestle, F.O. The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J. Invest. Dermatol., 2009, 129(6), 1339-1350.
[] [PMID: 19322214]
Korn, T.; Bettelli, E.; Oukka, M.; Kuchroo, V.K. IL-17 and Th17 Cells. Annu. Rev. Immunol., 2009, 27, 485-517.
[] [PMID: 19132915]
Blumberg, H.; Dinh, H.; Dean, C., Jr; Trueblood, E.S.; Bailey, K.; Shows, D.; Bhagavathula, N.; Aslam, M.N.; Varani, J.; Towne, J.E.; Sims, J.E. IL-1RL2 and its ligands contribute to the cytokine network in psoriasis. J. Immunol., 2010, 185(7), 4354-4362.
[] [PMID: 20833839]
Julià, A.; Tortosa, R.; Hernanz, J.M.; Cañete, J.D.; Fonseca, E.; Ferrándiz, C.; Unamuno, P.; Puig, L.; Fernández-Sueiro, J.L.; Sanmartí, R.; Rodríguez, J.; Gratacós, J.; Dauden, E.; Sánchez-Carazo, J.L.; López-Estebaranz, J.L.; Moreno-Ramírez, D.; Queiró, R.; Montilla, C.; Torre-Alonso, J.C.; Pérez-Venegas, J.J.; Vanaclocha, F.; Herrera, E.; Muñoz-Fernández, S.; González, C.; Roig, D.; Erra, A.; Acosta, I.; Fernández-Nebro, A.; Zarco, P.; Alonso, A.; López-Lasanta, M.; García-Montero, A.; Gelpí, J.L.; Absher, D.; Marsal, S. Risk variants for psoriasis vulgaris in a large case-control collection and association with clinical subphenotypes. Hum. Mol. Genet., 2012, 21(20), 4549-4557.
[] [PMID: 22814393]
Rahman, P.; Sun, S.; Peddle, L.; Snelgrove, T.; Melay, W.; Greenwood, C.; Gladman, D. Association between the interleukin-1 family gene cluster and psoriatic arthritis. Arthritis Rheum., 2006, 54(7), 2321-2325.
[] [PMID: 16918024]
Ravindran, J.S.; Owen, P.; Lagan, A.; Lewis, J.; Korendowych, E.; Welsh, K.; McHugh, N. Interleukin 1α interleukin 1β and interleukin 1 receptor gene polymorphisms in psoriatic arthritis. Rheumatology (Oxford), 2004, 43(1), 22-26.
[] [PMID: 12890860]
Bowes, J.; Ho, P.; Flynn, E.; Salah, S.; McHugh, N.; FitzGerald, O.; Packham, J.; Morgan, A.W.; Helliwell, P.S.; Bruce, I.N.; Barton, A. Investigation of IL1, VEGF, PPARG and MEFV genes in psoriatic arthritis susceptibility. Ann. Rheum. Dis., 2012, 71(2), 313-314.
[] [PMID: 21803748]
Oppmann, B.; Lesley, R.; Blom, B.; Timans, J.C.; Xu, Y.; Hunte, B.; Vega, F.; Yu, N.; Wang, J.; Singh, K.; Zonin, F.; Vaisberg, E.; Churakova, T.; Liu, M.; Gorman, D.; Wagner, J.; Zurawski, S.; Liu, Y.; Abrams, J.S.; Moore, K.W.; Rennick, D.; de Waal-Malefyt, R.; Hannum, C.; Bazan, J.F.; Kastelein, R.A. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity, 2000, 13(5), 715-725.
[] [PMID: 11114383]
Pappu, R.; Ramirez-Carrozzi, V.; Sambandam, A. The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases. Immunology, 2011, 134(1), 8-16.
[] [PMID: 21726218]
Szodoray, P.; Alex, P.; Chappell-Woodward, C.M.; Madland, T.M.; Knowlton, N.; Dozmorov, I.; Zeher, M.; Jarvis, J.N.; Nakken, B.; Brun, J.G.; Centola, M. Circulating cytokines in Norwegian patients with psoriatic arthritis determined by a multiplex cytokine array system. Rheumatology (Oxford), 2007, 46(3), 417-425.
[] [PMID: 16936328]
Lee, E.; Trepicchio, W.L.; Oestreicher, J.L.; Pittman, D.; Wang, F.; Chamian, F.; Dhodapkar, M.; Krueger, J.G. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J. Exp. Med., 2004, 199(1), 125-130.
[] [PMID: 14707118]
Tang, C.; Chen, S.; Qian, H.; Huang, W. Interleukin-23: As a drug target for autoimmune inflammatory diseases. Immunology, 2012, 135(2), 112-124.
[] [PMID: 22044352]
Langrish, C.L.; Chen, Y.; Blumenschein, W.M.; Mattson, J.; Basham, B.; Sedgwick, J.D.; McClanahan, T.; Kastelein, R.A.; Cua, D.J. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med., 2005, 201(2), 233-240.
[] [PMID: 15657292]
Harris, T.J.; Grosso, J.F.; Yen, H-R.; Xin, H.; Kortylewski, M.; Albesiano, E.; Hipkiss, E.L.; Getnet, D.; Goldberg, M.V.; Maris, C.H.; Housseau, F.; Yu, H.; Pardoll, D.M.; Drake, C.G. Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J. Immunol., 2007, 179(7), 4313-4317.
[] [PMID: 17878325]
Tanaka, K.; Ichiyama, K.; Hashimoto, M.; Yoshida, H.; Takimoto, T.; Takaesu, G.; Torisu, T.; Hanada, T.; Yasukawa, H.; Fukuyama, S.; Inoue, H.; Nakanishi, Y.; Kobayashi, T.; Yoshimura, A. Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-γ on STAT3 and Smads. J. Immunol., 2008, 180(6), 3746-3756.
[] [PMID: 18322180]
Moisan, J.; Grenningloh, R.; Bettelli, E.; Oukka, M.; Ho, I-C. Ets-1 is a negative regulator of Th17 differentiation. J. Exp. Med., 2007, 204(12), 2825-2835.
[] [PMID: 17967903]
Novatchkova, M.; Leibbrandt, A.; Werzowa, J.; Neubüser, A.; Eisenhaber, F. The STIR-domain superfamily in signal transduction, development and immunity. Trends Biochem. Sci., 2003, 28(5), 226-229.
[] [PMID: 12765832]
Toy, D.; Kugler, D.; Wolfson, M.; Vanden Bos, T.; Gurgel, J.; Derry, J.; Tocker, J.; Peschon, J. Cutting edge: Interleukin 17 signals through a heteromeric receptor complex. J. Immunol., 2006, 177(1), 36-39.
[] [PMID: 16785495]
Lubberts, E. IL-17/Th17 targeting: On the road to prevent chronic destructive arthritis? Cytokine, 2008, 41(2), 84-91.
[] [PMID: 18039580]
Chabaud, M.; Lubberts, E.; Joosten, L.; van Den Berg, W.; Miossec, P. IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis. Arthritis Res., 2001, 3(3), 168-177.
[] [PMID: 11299057]
Raychaudhuri, S.P.; Raychaudhuri, S.K.; Genovese, M.C. IL-17 receptor and its functional significance in psoriatic arthritis. Mol. Cell. Biochem., 2012, 359(1-2), 419-429.
[] [PMID: 21894442]
Mrabet, D.; Laadhar, L.; Sahli, H.; Zouari, B.; Haouet, S.; Makni, S.; Sellami, S. Synovial fluid and serum levels of IL-17, IL-23, and CCL-20 in rheumatoid arthritis and psoriatic arthritis: a Tunisian cross-sectional study. Rheumatol. Int., 2013, 33(1), 265-266.
[] [PMID: 22083617]
Tonel, G.; Conrad, C.; Laggner, U.; Di Meglio, P.; Grys, K.; McClanahan, T.K.; Blumenschein, W.M.; Qin, J.Z.; Xin, H.; Oldham, E.; Kastelein, R.; Nickoloff, B.J.; Nestle, F.O. Cutting edge: A critical functional role for IL-23 in psoriasis. J. Immunol., 2010, 185(10), 5688-5691.
[] [PMID: 20956338]
Wilson, N.J.; Boniface, K.; Chan, J.R.; McKenzie, B.S.; Blumenschein, W.M.; Mattson, J.D.; Basham, B.; Smith, K.; Chen, T.; Morel, F.; Lecron, J.C.; Kastelein, R.A.; Cua, D.J.; McClanahan, T.K.; Bowman, E.P.; de Waal Malefyt, R. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat. Immunol., 2007, 8(9), 950-957.
[] [PMID: 17676044]
Nititham, J.; Fergusson, C.; Palmer, C.; Liao, W.; Foerster, J. Candidate long-range regulatory sites acting on the IL17 pathway genes TRAF3IP2 and IL17RA are associated with psoriasis. Exp. Dermatol., 2018, 27(11), 1294-1297.
[] [PMID: 30076642]
Feinberg, M.W.; Cao, Z.; Wara, A.K.; Lebedeva, M.A.; Senbanerjee, S.; Jain, M.K. Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages. J. Biol. Chem., 2005, 280(46), 38247-38258.
[] [PMID: 16169848]
Huber, M.; Brüstle, A.; Reinhard, K.; Guralnik, A.; Walter, G.; Mahiny, A.; von Löw, E.; Lohoff, M. IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc. Natl. Acad. Sci. USA, 2008, 105(52), 20846-20851.
[] [PMID: 19088203]
Ammar, M.; Bouchlaka-Souissi, C.; Zaraa, I.; Helms, C.; Doss, N.; Bouazizi, F.; Dhaoui, R.; Ossman, A.B.; Ammar-el Gaied, A.B.; Mokni, M. Family-based association study in Tunisian familial psoriasis. Int. J. Dermatol., 2012, 51(11), 1329-1334.
[] [PMID: 23067081]
Catanoso, M.G.; Boiardi, L.; Macchioni, P.; Garagnani, P.; Sazzini, M.; De Fanti, S.; Farnetti, E.; Casali, B.; Chiarolanza, I.; Nicoli, D.; Luiselli, D.; Salvarani, C. IL-23A, IL-23R, IL-17A and IL-17R polymorphisms in different psoriatic arthritis clinical manifestations in the northern Italian population. Rheumatol. Int., 2013, 33(5), 1165-1176.
[] [PMID: 22955875]
Prans, E.; Kingo, K.; Traks, T.; Silm, H.; Vasar, E.; Kõks, S. Copy number variations in IL22 gene are associated with Psoriasis vulgaris. Hum. Immunol., 2013, 74(6), 792-795.
[] [PMID: 23395647]
Tohyama, M.; Hanakawa, Y.; Shirakata, Y.; Dai, X.; Yang, L.; Hirakawa, S.; Tokumaru, S.; Okazaki, H.; Sayama, K.; Hashimoto, K. IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression. Eur. J. Immunol., 2009, 39(10), 2779-2788.
[] [PMID: 19731362]
Kutwin, M. Migdalska-Sęk, M.; Brzeziańska-Lasota, E.; Zelga, P.; Woźniacka, A. Analysis of molecular markers as IL-12, IL-22 and IFN-γ in correlation with a clinical course in patients with psoriasis. Int. J. Occup. Med. Environ. Health, 2020, 33(5), 635-647.
[] [PMID: 32699424]
Saeki, H.; Hirota, T.; Nakagawa, H.; Tsunemi, Y.; Kato, T.; Shibata, S.; Sugaya, M.; Sato, S.; Doi, S.; Miyatake, A.; Ebe, K.; Noguchi, E.; Ebihara, T.; Amagai, M.; Esaki, H.; Takeuchi, S.; Furue, M.; Nakamura, Y.; Tamari, M. Genetic polymorphisms in the IL22 gene are associated with Psoriasis vulgaris in a Japanese population. J. Dermatol. Sci., 2013, 71(2), 148-150.
[] [PMID: 23664643]
Yang, X.O.; Pappu, B.P.; Nurieva, R.; Akimzhanov, A.; Kang, H.S.; Chung, Y.; Ma, L.; Shah, B.; Panopoulos, A.D.; Schluns, K.S.; Watowich, S.S.; Tian, Q.; Jetten, A.M.; Dong, C. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR α and ROR γ. Immunity, 2008, 28(1), 29-39.
[] [PMID: 18164222]
Korn, T.; Bettelli, E.; Gao, W.; Awasthi, A.; Jäger, A.; Strom, T.B.; Oukka, M.; Kuchroo, V.K. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature, 2007, 448(7152), 484-487.
[] [PMID: 17581588]
Nurieva, R.; Yang, X.O.; Martinez, G.; Zhang, Y.; Panopoulos, A.D.; Ma, L.; Schluns, K.; Tian, Q.; Watowich, S.S.; Jetten, A.M.; Dong, C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature, 2007, 448(7152), 480-483.
[] [PMID: 17581589]
Caruso, R.; Botti, E.; Sarra, M.; Esposito, M.; Stolfi, C.; Diluvio, L.; Giustizieri, M.L.; Pacciani, V.; Mazzotta, A.; Campione, E.; Macdonald, T.T.; Chimenti, S.; Pallone, F.; Costanzo, A.; Monteleone, G. Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis. Nat. Med., 2009, 15(9), 1013-1015.
[] [PMID: 19684581]
He, Z.; Jin, L.; Liu, Z.F.; Hu, L.; Dang, E.L.; Feng, Z.Z.; Li, Q.J.; Wang, G. Elevated serum levels of interleukin 21 are associated with disease severity in patients with psoriasis. Br. J. Dermatol., 2012, 167(1), 191-193.
[] [PMID: 22356196]
Warren, R.B.; Smith, R.L.; Flynn, E.; Bowes, J.; Eyre, S.; Worthington, J.; Barton, A.; Griffiths, C.E. A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21. Br. J. Dermatol., 2011, 164(3), 660-664.
[] [PMID: 21375519]
Bowes, J.; Orozco, G.; Flynn, E.; Ho, P.; Brier, R. Marzo-Ortega, H Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis. Ann. Rheumat. Dis., 2011, 2011, 150102.
Zhu, K-J.; Zhu, C-Y.; Shi, G.; Fan, Y-M. Association of IL23R polymorphisms with psoriasis and psoriatic arthritis: A meta-analysis. Inflamm. Res., 2012, 61(10), 1149-1154.
[] [PMID: 22706445]
Cénit, M.C.; Ortego-Centeno, N.; Raya, E.; Callejas, J.L.; García-Hernandez, F.J.; Castillo-Palma, M.J.; Fernandez-Sueiro, J.L.; Magro, C.; Solans, R.; Castañeda, S.; Camps, M.; Hidalgo, A.; Espinosa, G.; González-Gay, M.A.; González-Escribano, M.F.; Martín, J. Influence of the STAT3 genetic variants in the susceptibility to psoriatic arthritis and Behcet’s disease. Hum. Immunol., 2013, 74(2), 230-233.
[] [PMID: 23127549]
Sayed, K.S.; El-Komy, M.H.M.; Shehata, H.; ElShazly, S.H.; El Desouky, E.D.; Amr, K.S.; ElAraby, N.M.; AlOrbani, A.M. JAK1 rs310241 and JAK3 rs3008 Genotypes may increase susceptibility to psoriasis: A case control study. Skin Pharmacol. Physiol., 2020, 33(4), 207-212.
[] [PMID: 32877908]
Dou, J.; Zhang, L.; Xie, X.; Ye, L.; Yang, C.; Wen, L.; Shen, C.; Zhu, C.; Zhao, S.; Zhu, Z.; Liang, B.; Wang, Z.; Li, H.; Fan, X.; Liu, S.; Yin, X.; Zheng, X.; Sun, L.; Yang, S.; Cui, Y.; Zhou, F.; Zhang, X. Integrative analyses reveal biological pathways and key genes in psoriasis. Br. J. Dermatol., 2017, 177(5), 1349-1357.
[] [PMID: 28542811]

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