Abstract
Both stem cells and cancer cells can proliferate indefinitely. In many case, cancers consist of the cells expressing tissue-specific stem cell markers and the cells expressing differentiation markers. Moreover, it has been revealed that many cancer cells express ATP-binding cassette (ABC) transporters, by which the cells pump out a specific fluorescence dyes as well as anti-cancer drugs. Thus these finding suggest that either cancer cells resemble stem cells or cancers contain stem cell-like cells. Using the common characteristics between brain cancer cells and neural stem cells, several research groups have succeeded to identify stem cell-like brain cancer cells (called “brain cancer stem cells”) in brain tumors and brain cancer cell lines. The brain cancer stem cells, but not the other cancer cells, self-renew, form tumors when transplanted in vivo, and are highly resistant for both anti-cancer drugs and irradiation. Together all, these recent progresses suggest that it is crucial to characterize brain cancer stem cells and identify targets for the therapy.
Keywords: Cancer stem cells (CSCs), CD133, side population (SP), cell of origin, neural stem cells (NSCs)
Current Cancer Therapy Reviews
Title: Stem Cell-Like Brain Cancer Cells
Volume: 4 Issue: 3
Author(s): Toru Kondo
Affiliation:
Keywords: Cancer stem cells (CSCs), CD133, side population (SP), cell of origin, neural stem cells (NSCs)
Abstract: Both stem cells and cancer cells can proliferate indefinitely. In many case, cancers consist of the cells expressing tissue-specific stem cell markers and the cells expressing differentiation markers. Moreover, it has been revealed that many cancer cells express ATP-binding cassette (ABC) transporters, by which the cells pump out a specific fluorescence dyes as well as anti-cancer drugs. Thus these finding suggest that either cancer cells resemble stem cells or cancers contain stem cell-like cells. Using the common characteristics between brain cancer cells and neural stem cells, several research groups have succeeded to identify stem cell-like brain cancer cells (called “brain cancer stem cells”) in brain tumors and brain cancer cell lines. The brain cancer stem cells, but not the other cancer cells, self-renew, form tumors when transplanted in vivo, and are highly resistant for both anti-cancer drugs and irradiation. Together all, these recent progresses suggest that it is crucial to characterize brain cancer stem cells and identify targets for the therapy.
Export Options
About this article
Cite this article as:
Kondo Toru, Stem Cell-Like Brain Cancer Cells, Current Cancer Therapy Reviews 2008; 4 (3) . https://dx.doi.org/10.2174/157339408785294258
DOI https://dx.doi.org/10.2174/157339408785294258 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Advancements in Lipid Nanoparticle Delivery Systems for mRNA Therapeutics
The thematic issue will focus on key areas such as lipid nanoparticles, mRNA therapeutics, drug delivery systems, nanotechnology in medicine, targeted therapy, non-viral vectors, precision medicine, and biomedical engineering.read more
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A Comparative Molecular Field (CoMFA) Studies on Carbonic Anhydrase Inhibitor hCA IX-Tumor-Associated (Hypoxia)
Letters in Drug Design & Discovery Re-Examining the Need for Tissue Diagnosis in Pediatric Diffuse Intrinsic Pontine Gliomas: A Review
Current Neuropharmacology Delineation of Current Development of Antimitotic Compounds Targeting Cytoskeletal Protein Tubulin and Microtubule in the Cancer Therapy
Current Chemical Biology Peptides to Target Tumor Vasculature and Lymphatics for Improved Anti-Angiogenesis Therapy
Current Cancer Drug Targets Contribution of Inflammation to Fat Redistribution and Metabolic Disturbances in HIV-1 Infected Patients
Current Pharmaceutical Design Novel Agents Targeting Bioactive Sphingolipids for the Treatment of Cancer
Current Medicinal Chemistry Role of Early Growth Response-1 in the Development of Alcohol-Induced Steatosis
Current Molecular Pharmacology Honey as a Source of Dietary Antioxidants: Structures, Bioavailability and Evidence of Protective Effects Against Human Chronic Diseases
Current Medicinal Chemistry Role of Histone Deacetylases (HDACs) in Epilepsy and Epileptogenesis
Current Pharmaceutical Design Intracellular Drug Delivery: Mechanisms for Cell Entry
Current Pharmaceutical Design Targeting Chemokine Receptor CXCR4 for Treatment of HIV-1 Infection, Tumor Progression, and Metastasis
Current Topics in Medicinal Chemistry The Regulatory Role of Both MBNL1 and MBNL1-AS1 in Several Common Cancers
Current Pharmaceutical Design Ectonucleotidases and Nucleotide/Nucleoside Transporters as Pharmacological Targets for Neurological Disorders
CNS & Neurological Disorders - Drug Targets Polo-Like Kinase 1 as a Potential Therapeutic Target for Osteosarcoma
Current Pharmaceutical Design Antagonists of IAP Proteins: Novel Anti-Tumor Agents
Current Medicinal Chemistry Immune Checkpoint Regulators: A New Era Toward Promising Cancer Therapy
Current Cancer Drug Targets Delivery of Nanoparticles for Treatment of Brain Tumor
Current Drug Metabolism Innate Immune Receptors and IRF Family Transcription Factors
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents SANTAVAC ™: A Novel Universal Antigen Composition for Developing Cancer Vaccines
Recent Patents on Biotechnology Oleuropein Mediated Targeting of Signaling Network in Cancer
Current Topics in Medicinal Chemistry