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Current Pharmaceutical Biotechnology


ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Review Article

Long Noncoding RNAs in Human Cancer and Apoptosis

Author(s): İpek Erdoğan, Osama Sweef and Bünyamin Akgül*

Volume 24, Issue 7, 2023

Published on: 14 September, 2022

Page: [872 - 888] Pages: 17

DOI: 10.2174/1389201023666220624094950

Price: $65


Genome annotations have uncovered the production of at least one transcript from nearly all loci in the genome at some given time throughout the development. Surprisingly, many of these transcripts do not code for proteins and are relatively long in size, thus called long noncoding RNAs (lncRNAs). Next- and third-generation sequencing technologies have amassed numerous lncRNAs expressed under different phenotypic conditions, yet many remain to be functionally characterized. LncRNAs regulate gene expression by functioning as scaffold, decoy, signaling, and guide molecules both at the transcriptional and post-transcriptional levels, interacting with different types of macromolecules, such as proteins, DNA, and RNA. Here, we review the potential regulatory role of lncRNAs in apoptosis and cancer as some of these lncRNAs may have the diagnostic and therapeutic potential in cancer.

Keywords: lncRNAs, apoptosis, cancer, gene regulation, DNA, nucleotide.

Graphical Abstract
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