Abstract
Recent findings have demonstrated that the tumor stroma actively contributes to tumorigenesis. The communication of malignant cells and tumor stromal components is orchestrated in part by a network of growth factors. One of these growth factors is transforming growth factor-β (TGF-β), a secreted multifunctional protein that acts in a highly cellular contextual manner. TGF-β can either stimulate or inhibit the tumor-promoting effects of the different components of the tumor stroma. In this review, we discuss our current understanding on how TGF-β influences different stromal compartments.
Keywords: TGF-β, tumor stroma, CAF, angiogenesis, immune cells
Current Cancer Drug Targets
Title: Role of TGF- β in the Tumor Stroma
Volume: 8 Issue: 6
Author(s): H. P.H. Naber, P. ten Dijke and E. Pardali
Affiliation:
Keywords: TGF-β, tumor stroma, CAF, angiogenesis, immune cells
Abstract: Recent findings have demonstrated that the tumor stroma actively contributes to tumorigenesis. The communication of malignant cells and tumor stromal components is orchestrated in part by a network of growth factors. One of these growth factors is transforming growth factor-β (TGF-β), a secreted multifunctional protein that acts in a highly cellular contextual manner. TGF-β can either stimulate or inhibit the tumor-promoting effects of the different components of the tumor stroma. In this review, we discuss our current understanding on how TGF-β influences different stromal compartments.
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Cite this article as:
Naber P.H. H., ten Dijke P. and Pardali E., Role of TGF- β in the Tumor Stroma, Current Cancer Drug Targets 2008; 8 (6) . https://dx.doi.org/10.2174/156800908785699342
DOI https://dx.doi.org/10.2174/156800908785699342 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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