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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Systematic Review Article

Imaging Markers of Neurologic Damage in COVID-19: A Systematic Review

Author(s): Sara Tavares Araújo, Clara Tavares Araújo, Rafael Silva e Castro, Lara Machado de Oliveira Brügger, Nathália Gualberto Souza e Silva, Debora Marques de Miranda and Ana Cristina Simões e Silva*

Volume 30, Issue 9, 2023

Published on: 21 September, 2022

Page: [1086 - 1106] Pages: 21

DOI: 10.2174/0929867329666220701124945

Price: $65


Background and Objectives: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection commonly leads to neurologic manifestations. In the present review, we aimed to investigate potential neuroimaging markers of early diagnosis and prognosis of neurologic manifestations in COVID-19.

Methods: Our study was registered in the Prospective Register of Systematic Reviews (PROSPERO) under the protocol CDR42021265443. Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we selected 51 studies for whole-manuscript analysis.

Results: Magnetic resonance imaging (MRI) was the most common imaging method. The pattern, sites of lesion, signs, and symptoms of neurologic injury varied. Such manifestations possibly resulted from a direct viral infection or, most likely, from indirect mechanisms including coagulation disturbances, hypoxemia, and immunological responses.

Conclusion: The heterogeneity of the studies precludes any generalization of the findings. Brain MRI is the most informative imaging exam. Population studies, including the entire spectrum of COVID-19 are missing. There is still a need for future population studies evaluating neurologic manifestations of all COVID-19 severities acutely and chronically.

Keywords: Imaging, PET-CT, MRI, COVID-19, SARS-CoV-2, brain, neurologic.

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Mahammedi, A.; Saba, L.; Vagal, A.; Leali, M.; Rossi, A.; Gaskill, M.; Sengupta, S.; Zhang, B.; Carriero, A.; Bachir, S.; Crivelli, P.; Paschè, A.; Premi, E.; Padovani, A.; Gasparotti, R. Imaging of neurologic disease in hospitalized patients with COVID-19: An Italian multicenter retrospective observational study. Radiology, 2020, 297(2), E270-E273.
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García-Azorín, D.; Abildúa, M.J.A.; Aguirre, M.E.E.; Fernández, S.F.; Moncó, J.C.G.; Guijarro-Castro, C.; Platas, M.G.; Delgado, F.R.; Andrés, J.M.L.; Ezpeleta, D. Neurological presentations of COVID-19: Findings from the spanish society of neurology neuro COVID-19 registry. J. Neurol. Sci., 2021, 423, 117283.
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Klironomos, S.; Tzortzakakis, A.; Kits, A.; Öhberg, C.; Kollia, E.; Ahoromazdae, A.; Almqvist, H.; Aspelin, Å.; Martin, H.; Ouellette, R.; Al-Saadi, J.; Hasselberg, M.; Haghgou, M.; Pedersen, M.; Petersson, S.; Finnsson, J.; Lundberg, J.; Falk Delgado, A.; Granberg, T. Nervous system involvement in coronavirus disease 2019: Results from a retrospective consecutive neuroimaging cohort. Radiology, 2020, 297(3), E324-E334.
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