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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Mini-Review Article

Overview of Piperine: Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships

Author(s): Shaochen Li, Min Lv* and Hui Xu*

Volume 23, Issue 8, 2023

Published on: 12 October, 2022

Page: [917 - 940] Pages: 24

DOI: 10.2174/1389557522666220726121012

Price: $65


Natural products are an invaluable source for the discovery of drug and pesticide candidates. Piperine, a simple and pungent alkaloid, is isolated from several plants of Piperaceae. Piperine and its derivatives displayed a wide range of biological properties, such as antitumor activity, anti-inflammatory activity, antioxidant activity, neuroprotective activity, insecticidal activity, etc. In recent years, lots of works focused on the biological activities, mechanisms of action, total synthesis, and structural modifications of piperine and its derivatives have been conducted. To the best of our knowledge, however, few review articles related to the biological activities, mechanisms of action, total synthesis, and structural modifications of piperine and its derivatives have been reported to date. Therefore, this review summarizes the research advances (from 2014 to 2020) of piperine and its derivatives regarding bioactivity, mechanisms of action, total synthesis, and structural modifications. Meanwhile, the structure-activity relationships of piperine and its derivatives are also discussed.

Keywords: Piperine, biological activity, mechanism of action, total synthesis, structural modification, structure-activity relationship.

Graphical Abstract
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