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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Review Article

Synthesis and Pharmacological Activity of 4', 4''- bit Modified Curcumin Derivatives

Author(s): Yan Tan, Jiajia Lang, Meilun Tang, Pengbing Mi* and Xing Zheng*

Volume 20, Issue 12, 2023

Published on: 26 September, 2022

Page: [1884 - 1897] Pages: 14

DOI: 10.2174/1570180819666220806145656

Price: $65


Background: Curcumin is a polyphenol compound extracted from plant turmeric with high pharmacological activities. The clinical application of curcumin is limited due to the shortcomings of poor water solubility, instability, and low bioavailability.

Objective: Modifying the 4', 4''-bit of curcumin is an effective strategy to improve the pharmacological activity of curcumin.

Conclusion: In this review, we focused on the strategy of synthesis, medicinal properties, and structurefunction relationship of 4', 4''-bit modified curcumin derivatives.

Keywords: Curcumin, 4', 4''-bit modified, pharmacological activity, synthesis, derivative, structure-function.

Graphical Abstract
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