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Current Aging Science

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ISSN (Print): 1874-6098
ISSN (Online): 1874-6128

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Mini-Review Article

Cocoa Flavanols and the Aging Brain

Author(s): Robert Lalonde* and Catherine Strazielle

Volume 16, Issue 1, 2023

Published on: 27 September, 2022

Page: [2 - 11] Pages: 10

DOI: 10.2174/1874609815666220819145845

Price: $65

Abstract

Partly because of its antioxidant and anti-inflammatory properties, cocoa flavanols have been examined in reversing age-related cognitive deficits. Epidemiological studies indicate a relation between flavonoid intake and the prevention of dementia. In confirmation of this relation, several pharmacological studies show the faster speed of responding and better executive performance in flavanol-treated aged or young subjects. The lack of any effect appears in some studies, especially in young subjects, perhaps due to the use of groups with high educational levels and the possibility of a ceiling effect. In several studies, neuropsychological ameliorations were followed by increases in cerebral blood flow. These results are in line with those of animal experimentation since improvements have been found in motor and spatial performances of young and aging mice or rats as well as animal models of Alzheimer’s disease and Parkinson’s disease. Improvements are also reported in biologic markers of Alzheimer’s disease, in particular an increase in soluble Aβ and a decrease in tau hyperphosphorylation.

Keywords: Flavonoids, flavanols, executive functions, reaction time, memory, cerebral blood flow.

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Graphical Abstract

[1]
Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: An overview. Scient World J 2013; 2013, 162750.
[http://dx.doi.org/10.1155/2013/162750] [PMID: 24470791]
[2]
Panche AN, Diwan AD, Chandra SR. Flavonoids: An overview. J Nutr Sci 2016; 5, e47.
[http://dx.doi.org/10.1017/jns.2016.41] [PMID: 28620474]
[3]
Ramassamy C. Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: A review of their intracellular targets. Eur J Pharmacol 2006; 545(1): 51-64.
[http://dx.doi.org/10.1016/j.ejphar.2006.06.025] [PMID: 16904103]
[4]
Ross JA, Kasum CM. Dietary flavonoids: Bioavailability, metabolic effects, and safety. Annu Rev Nutr 2002; 22: 19-34.
[http://dx.doi.org/10.1146/annurev.nutr.22.111401.144957] [PMID: 12055336]
[5]
Bussy U, May BR, Olanrewaju Y. et al. Reliable, accessible and transferable method for the quantification of flavanols and procyanidins in foodstuffs and dietary supplements. Food Funct 2020; 11(1): 131-8.
[http://dx.doi.org/10.1039/C9FO02762A] [PMID: 31932823]
[6]
Osman H, Nasarudin R, Lee SL. Extracts of cocoa (Theobroma cacao L.) leaves and their antioxidation potential. Food Chem 2004; 86(1): 41-6.
[http://dx.doi.org/10.1016/j.foodchem.2003.08.026]
[7]
Cova I, Leta V, Mariani C, Pantoni L, Pomati S. Exploring cocoa properties: Is theobromine a cognitive modulator? Psychopharmacology 2019; 236(2): 561-72.
[http://dx.doi.org/10.1007/s00213-019-5172-0] [PMID: 30706099]
[8]
Martin MÁ, Ramos S. Impact of cocoa flavanols on human health. Food Chem Toxicol 2021; 151, 112121.
[http://dx.doi.org/10.1016/j.fct.2021.112121] [PMID: 33722594]
[9]
Tuenter E, Foubert K, Pieters L. Mood components in cocoa and chocolate: The mood pyramid. Planta Med 2018; 84(12-13): 839-44.
[http://dx.doi.org/10.1055/a-0588-5534] [PMID: 29539647]
[10]
Ellam S, Williamson G. Cocoa and human health. Annu Rev Nutr 2013; 33: 105-28.
[http://dx.doi.org/10.1146/annurev-nutr-071811-150642] [PMID: 23642199]
[11]
Katz DL, Doughty K, Ali A. Cocoa and chocolate in human health and disease. Antioxid Redox Signal 2011; 15(10): 2779-811.
[http://dx.doi.org/10.1089/ars.2010.3697] [PMID: 21470061]
[12]
Nehlig A. The neuroprotective effects of cocoa flavanol and its influence on cognitive performance. Br J Clin Pharmacol 2013; 75(3): 716-27.
[http://dx.doi.org/10.1111/j.1365-2125.2012.04378.x] [PMID: 22775434]
[13]
Selmi C, Mao TK, Keen CL, Schmitz HH, Eric Gershwin EM. The anti-inflammatory properties of cocoa flavanols. J Cardiovasc Pharmacol 2006; 47 (Suppl. 2): S163-71.
[http://dx.doi.org/10.1097/00005344-200606001-00010] [PMID: 16794453]
[14]
Spencer JP, Vafeiadou K, Williams RJ, Vauzour D. Neuroinflammation: Modulation by flavonoids and mechanisms of action. Mol Aspects Med 2012; 33(1): 83-97.
[http://dx.doi.org/10.1016/j.mam.2011.10.016] [PMID: 22107709]
[15]
Haskell-Ramsay CF, Schmitt J, Actis-Goretta L. The Impact of epicatechin on human cognition: The role of cerebral blood flow. Nutrients 2018; 10(8): 986.
[http://dx.doi.org/10.3390/nu10080986] [PMID: 30060538]
[16]
Dinges DF. Cocoa flavanols, cerebral blood flow, cognition, and health: Going forward. J Cardiovasc Pharmacol 2006; 47 (Suppl. 2): S221-3.
[http://dx.doi.org/10.1097/00005344-200606001-00019] [PMID: 16794462]
[17]
Kesse-Guyot E, Fezeu L, Andreeva VA. et al. Total and specific polyphenol intakes in midlife are associated with cognitive function measured 13 years later. J Nutr 2012; 142(1): 76-83.
[http://dx.doi.org/10.3945/jn.111.144428] [PMID: 22090468]
[18]
Letenneur L, Proust-Lima C, Le Gouge A, Dartigues JF, Barberger-Gateau P. Flavonoid intake and cognitive decline over a 10-year period. Am J Epidemiol 2007; 165(12): 1364-71.
[http://dx.doi.org/10.1093/aje/kwm036] [PMID: 17369607]
[19]
Commenges D, Scotet V, Renaud S, Jacqmin-Gadda H, Barberger-Gateau P, Dartigues JF. Intake of flavonoids and risk of dementia. Eur J Epidemiol 2000; 16(4): 357-63.
[http://dx.doi.org/10.1023/A:1007614613771] [PMID: 10959944]
[20]
Filippini T, Adani G, Malavolti M. et al. Dietary habits and risk of early-onset dementia in an Italian case-control study. Nutrients 2020; 12(12): 3682.
[http://dx.doi.org/10.3390/nu12123682] [PMID: 33260315]
[21]
Calabrò RS, De Cola MC, Gervasi G. et al. The efficacy of cocoa polyphenols in the treatment of mild cognitive impairment: A retrospective study. Medicina 2019; 55(5): 156.
[http://dx.doi.org/10.3390/medicina55050156] [PMID: 31108983]
[22]
Moreira A, Diógenes MJ, de Mendonça A, Lunet N, Barros H. Chocolate consumption is associated with a lower risk of cognitive decline. J Alzheimers Dis 2016; 53(1): 85-93.
[http://dx.doi.org/10.3233/JAD-160142] [PMID: 27163823]
[23]
Crichton GE, Elias MF, Alkerwi A. Chocolate intake is associated with better cognitive function: The maine-syracuse longitudinal study. Appetite 2016; 100: 126-32.
[http://dx.doi.org/10.1016/j.appet.2016.02.010] [PMID: 26873453]
[24]
Haller S, Montandon ML, Rodriguez C, Herrmann FR, Giannakopoulos P. Impact of coffee, wine, and chocolate consumption on cognitive outcome and MRI parameters in old age. Nutrients 2018; 10(10): 1391.
[http://dx.doi.org/10.3390/nu10101391] [PMID: 30275380]
[25]
Butchart C, Kyle J, McNeill G. et al. Flavonoid intake in relation to cognitive function in later life in the lothian birth cohort 1936. Br J Nutr 2011; 106(1): 141-8.
[http://dx.doi.org/10.1017/S0007114510005738] [PMID: 21303571]
[26]
Rabassa M, Cherubini A, Zamora-Ros R. et al. Low levels of a urinary biomarker of dietary polyphenol are associated with substantial cognitive decline over a 3-year period in older adults: The invecchiare in chianti study. J Am Geriatr Soc 2015; 63(5): 938-46.
[http://dx.doi.org/10.1111/jgs.13379] [PMID: 25919574]
[27]
Strandberg TE, Strandberg AY, Pitkälä K, Salomaa VV, Tilvis RS, Miettinen TA. Chocolate, well-being and health among elderly men. Eur J Clin Nutr 2008; 62(2): 247-53.
[http://dx.doi.org/10.1038/sj.ejcn.1602707] [PMID: 17327862]
[28]
Rose N, Koperski S, Golomb BA. Mood food: Chocolate and depressive symptoms in a cross-sectional analysis. Arch Intern Med 2010; 170(8): 699-703.
[http://dx.doi.org/10.1001/archinternmed.2010.78] [PMID: 20421555]
[29]
Parker G, Parker I, Brotchie H. Mood state effects of chocolate. J Affect Disord 2006; 92(2-3): 149-59.
[http://dx.doi.org/10.1016/j.jad.2006.02.007] [PMID: 16546266]
[30]
Scholey A, Owen L. Effects of chocolate on cognitive function and mood: A systematic review. Nutr Rev 2013; 71(10): 665-81.
[http://dx.doi.org/10.1111/nure.12065] [PMID: 24117885]
[31]
Mastroiacovo D, Kwik-Uribe C, Grassi D. et al. Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: The cocoa, cognition, and aging (CoCoA) study--a randomized controlled trial. Am J Clin Nutr 2015; 101(3): 538-48.
[http://dx.doi.org/10.3945/ajcn.114.092189] [PMID: 25733639]
[32]
Brickman AM, Khan UA, Provenzano FA. et al. Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults. Nat Neurosci 2014; 17(12): 1798-803.
[http://dx.doi.org/10.1038/nn.3850] [PMID: 25344629]
[33]
Sloan RP, Wall M, Yeung LK. et al. Insights into the role of diet and dietary flavanols in cognitive aging: Results of a randomized controlled trial. Sci Rep 2021; 11(1): 3837.
[http://dx.doi.org/10.1038/s41598-021-83370-2] [PMID: 33589674]
[34]
Sorond FA, Hurwitz S, Salat DH, Greve DN, Fisher ND. Neurovascular coupling, cerebral white matter integrity, and response to cocoa in older people. Neurology 2013; 81(10): 904-9.
[http://dx.doi.org/10.1212/WNL.0b013e3182a351aa] [PMID: 23925758]
[35]
Garcia-Yu IA, Garcia-Ortiz L, Gomez-Marcos MA. et al. Effects of cocoa-rich chocolate on cognitive performance in postmenopausal women: A randomised clinical trial. Nutr Neurosci 2022; 25(6): 1147-58.
[http://dx.doi.org/10.1080/1028415X.2020.1840119] [PMID: 33190575]
[36]
Neshatdoust S, Saunders C, Castle SM. et al. High-flavonoid intake induces cognitive improvements linked to changes in serum brain-derived neurotrophic factor: Two randomised, controlled trials. Nutr Healthy Aging 2016; 4(1): 81-93.
[http://dx.doi.org/10.3233/NHA-1615] [PMID: 28035345]
[37]
Munguia L, Rubio-Gayosso I, Ramirez-Sanchez I. et al. High flavonoid cocoa supplement ameliorates plasma oxidative stress and inflammation levels while improving mobility and quality of life in older subjects: A double-blind randomized clinical trial. J Gerontol A Biol Sci Med Sci 2019; 74(10): 1620-7.
[http://dx.doi.org/10.1093/gerona/glz107] [PMID: 31056655]
[38]
Suominen MH, Laaksonen MML, Salmenius-Suominen H. et al. The short-term effect of dark chocolate flavanols on cognition in older adults: A randomized controlled trial (FlaSeCo). Exp Gerontol 2020; 136, 110933.
[http://dx.doi.org/10.1016/j.exger.2020.110933] [PMID: 32229139]
[39]
Crews WD Jr, Harrison DW, Wright JW. A double-blind, placebo-controlled, randomized trial of the effects of dark chocolate and cocoa on variables associated with neuropsychological functioning and cardiovascular health: Clinical findings from a sample of healthy, cognitively intact older adults. Am J Clin Nutr 2008; 87(4): 872-80.
[http://dx.doi.org/10.1093/ajcn/87.4.872] [PMID: 18400709]
[40]
Pase MP, Scholey AB, Pipingas A. et al. Cocoa polyphenols enhance positive mood states but not cognitive performance: A randomized, placebo-controlled trial. J Psychopharmacol 2013; 27(5): 451-8.
[http://dx.doi.org/10.1177/0269881112473791] [PMID: 23364814]
[41]
Marsh CE, Carter HH, Guelfi KJ. et al. Brachial and cerebrovascular functions are enhanced in postmenopausal women after ingestion of chocolate with a high concentration of cocoa. J Nutr 2017; 147(9): 1686-92.
[http://dx.doi.org/10.3945/jn.117.250225] [PMID: 28794213]
[42]
Sorond FA, Lipsitz LA, Hollenberg NK, Fisher ND. Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans. Neuropsychiatr Dis Treat 2008; 4(2): 433-40.
[PMID: 18728792]
[43]
Sorond FA, Hollenberg NK, Panych LP, Fisher ND. Brain blood flow and velocity: Correlations between magnetic resonance imaging and transcranial doppler sonography. J Ultrasound Med 2010; 29(7): 1017-22.
[http://dx.doi.org/10.7863/jum.2010.29.7.1017] [PMID: 20587424]
[44]
Lamport DJ, Pal D, Moutsiana C. et al. The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: A placebo controlled, crossover, acute trial. Psychopharmacology 2015; 232(17): 3227-34.
[http://dx.doi.org/10.1007/s00213-015-3972-4] [PMID: 26047963]
[45]
Desideri G, Kwik-Uribe C, Grassi D. et al. Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: The cocoa, cognition, and aging (CoCoA) study. Hypertension 2012; 60(3): 794-801.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.193060] [PMID: 22892813]
[46]
Decroix L, van Schuerbeek P, Tonoli C. et al. The effect of acute cocoa flavanol intake on the BOLD response and cognitive function in type 1 diabetes: A randomized, placebo-controlled, double-blinded cross-over pilot study. Psychopharmacology 2019; 236(12): 3421-8.
[http://dx.doi.org/10.1007/s00213-019-05306-z] [PMID: 31236643]
[47]
McDermott MM, Criqui MH, Domanchuk K. et al. Cocoa to improve walking performance in older people with peripheral artery disease: The COCOA-PAD pilot randomized clinical trial. Circ Res 2020; 126(5): 589-99.
[http://dx.doi.org/10.1161/CIRCRESAHA.119.315600] [PMID: 32078436]
[48]
García-Cordero J, Pino A, Cuevas C, Puertas-Martín V, San Román R, de Pascual-Teresa S. Neurocognitive effects of cocoa and red-berries consumption in healthy adults. Nutrients 2021; 14(1): 1.
[http://dx.doi.org/10.3390/nu14010001] [PMID: 35010877]
[49]
Karabay A, Saija JD, Field DT, Akyürek EG. The acute effects of cocoa flavanols on temporal and spatial attention. Psychopharmacology 2018; 235(5): 1497-511.
[http://dx.doi.org/10.1007/s00213-018-4861-4] [PMID: 29502273]
[50]
Scholey AB, French SJ, Morris PJ, Kennedy DO, Milne AL, Haskell CF. Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort. J Psychopharmacol 2010; 24(10): 1505-14.
[http://dx.doi.org/10.1177/0269881109106923] [PMID: 19942640]
[51]
Massee LA, Ried K, Pase M. et al. The acute and sub-chronic effects of cocoa flavanols on mood, cognitive and cardiovascular health in young healthy adults: A randomized, controlled trial. Front Pharmacol 2015; 6: 93.
[http://dx.doi.org/10.3389/fphar.2015.00093] [PMID: 26042037]
[52]
Field DT, Williams CM, Butler LT. Consumption of cocoa flavanols results in an acute improvement in visual and cognitive functions. Physiol Behav 2011; 103(3-4): 255-60.
[http://dx.doi.org/10.1016/j.physbeh.2011.02.013] [PMID: 21324330]
[53]
Sumiyoshi E, Matsuzaki K, Sugimoto N. et al. Sub-chronic consumption of dark chocolate enhances cognitive function and releases nerve growth factors: A parallel-group randomized trial. Nutrients 2019; 11(11): 2800.
[http://dx.doi.org/10.3390/nu11112800] [PMID: 31744119]
[54]
Lamport DJ, Pal D, Macready AL. et al. The effects of flavanone-rich citrus juice on cognitive function and cerebral blood flow: An acute, randomised, placebo-controlled cross-over trial in healthy, young adults. Br J Nutr 2016; 116(12): 2160-8.
[http://dx.doi.org/10.1017/S000711451600430X] [PMID: 28091350]
[55]
Gratton G, Weaver SR, Burley CV. et al. Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults. Sci Rep 2020; 10(1): 19409.
[http://dx.doi.org/10.1038/s41598-020-76160-9] [PMID: 33235219]
[56]
Grassi D, Socci V, Tempesta D. et al. Flavanol-rich chocolate acutely improves arterial function and working memory performance counteracting the effects of sleep deprivation in healthy individuals. J Hypertens 2016; 34(7): 1298-308.
[http://dx.doi.org/10.1097/HJH.0000000000000926] [PMID: 27088635]
[57]
Altınok A, Karabay A, Akyürek EG. Acute effects of cocoa flavanols on visual working memory: Maintenance and updating. Eur J Nutr 2022; 61(3): 1665-78.
[http://dx.doi.org/10.1007/s00394-021-02767-x] [PMID: 35031887]
[58]
Camfield DA, Scholey A, Pipingas A. et al. Steady state visually evoked potential (SSVEP) topography changes associated with cocoa flavanol consumption. Physiol Behav 2012; 105(4): 948-57.
[http://dx.doi.org/10.1016/j.physbeh.2011.11.013] [PMID: 22120044]
[59]
Francis ST, Head K, Morris PG, Macdonald IA. The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people. J Cardiovasc Pharmacol 2006; 47 (Suppl. 2): S215-20.
[http://dx.doi.org/10.1097/00005344-200606001-00018] [PMID: 16794461]
[60]
Decroix L, Tonoli C, Soares DD, Tagougui S, Heyman E, Meeusen R. Acute cocoa flavanol improves cerebral oxygenation without enhancing executive function at rest or after exercise. Appl Physiol Nutr Metab 2016; 41(12): 1225-32.
[http://dx.doi.org/10.1139/apnm-2016-0245] [PMID: 27849355]
[61]
Barrera-Reyes PK, de Lara JC, González-Soto M, Tejero ME. Effects of cocoa-derived polyphenols on cognitive function in humans: Systematic review and analysis of methodological aspects. Plant Foods Hum Nutr 2020; 75(1): 1-11.
[http://dx.doi.org/10.1007/s11130-019-00779-x] [PMID: 31933112]
[62]
Lamport DJ, Williams CM. Polyphenols and cognition in humans: An overview of current evidence from recent systematic reviews and meta-analyses. Brain Plast 2021; 6(2): 139-53.
[http://dx.doi.org/10.3233/BPL-200111] [PMID: 33782647]
[63]
Tan TYC, Lim XY, Yeo JHH, Lee SWH, Lai NM. The health effects of chocolate and cocoa: A systematic review. Nutrients 2021; 13(9): 2909.
[http://dx.doi.org/10.3390/nu13092909] [PMID: 34578786]
[64]
Caruso G, Torrisi SA, Mogavero MP. et al. Polyphenols and neuroprotection: Therapeutic implications for cognitive decline. Pharmacol Ther 2021; 232, 108013.
[http://dx.doi.org/10.1016/j.pharmthera.2021.108013] [PMID: 34624428]
[65]
Macht M, Mueller J. Immediate effects of chocolate on experimentally induced mood states. Appetite 2007; 49(3): 667-74.
[http://dx.doi.org/10.1016/j.appet.2007.05.004] [PMID: 17597253]
[66]
Decroix L, Tonoli C, Lespagnol E. et al. One-week cocoa flavanol intake increases prefrontal cortex oxygenation at rest and during moderate-intensity exercise in normoxia and hypoxia. J Appl Physiol 2018; 125(1): 8-18.
[http://dx.doi.org/10.1152/japplphysiol.00055.2018] [PMID: 29543135]
[67]
Fisher ND, Sorond FA, Hollenberg NK. Cocoa flavanols and brain perfusion. J Cardiovasc Pharmacol 2006; 47 (Suppl. 2): S210-4.
[http://dx.doi.org/10.1097/00005344-200606001-00017] [PMID: 16794460]
[68]
Schroeter H, Heiss C, Balzer J. et al. (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci USA 2006; 103(4): 1024-9.
[http://dx.doi.org/10.1073/pnas.0510168103] [PMID: 16418281]
[69]
Martín MÁ, Goya L, de Pascual-Teresa S. Effect of cocoa and cocoa products on cognitive performance in young adults. Nutrients 2020; 12(12): 3691.
[http://dx.doi.org/10.3390/nu12123691] [PMID: 33265948]
[70]
Patel AK, Rogers JT, Huang X. Flavanols, mild cognitive impairment, and Alzheimer’s dementia. Int J Clin Exp Med 2008; 1(2): 181-91.
[PMID: 19079672]
[71]
Petrone AB, Gaziano JM, Djousse L. The effects of dark chocolate and cocoa products on endothelial function: A meta analysis. Curr Nutr Rep 2013; 2: 267-73.
[http://dx.doi.org/10.1007/s13668-013-0058-y]
[72]
Socci V, Tempesta D, Desideri G, De Gennaro L, Ferrara M. Enhancing human cognition with cocoa flavonoids. Front Nutr 2017; 4: 19.
[http://dx.doi.org/10.3389/fnut.2017.00019] [PMID: 28560212]
[73]
Gardener SL, Rainey-Smith SR, Weinborn M, Bondonno CP, Martins RN. Intake of products containing anthocyanins, flavanols, and flavanones, and cognitive function: A narrative review. Front Aging Neurosci 2021; 13, 640381.
[http://dx.doi.org/10.3389/fnagi.2021.640381] [PMID: 34539375]
[74]
Sokolov AN, Pavlova MA, Klosterhalfen S, Enck P. Chocolate and the brain: Neurobiological impact of cocoa flavanols on cognition and behavior. Neurosci Biobehav Rev 2013; 37(10 Pt 2): 2445-53.
[http://dx.doi.org/10.1016/j.neubiorev.2013.06.013] [PMID: 23810791]
[75]
Munguia L, Ramirez-Sanchez I, Meaney E, Villarreal F, Ceballos G, Najera N. Flavonoids from dark chocolate and (-)-epicatechin ameliorate high-fat diet-induced decreases in mobility and muscle damage in aging mice. Food Biosci 2020; 37, 100710.
[http://dx.doi.org/10.1016/j.fbio.2020.100710] [PMID: 32953444]
[76]
Gras S, Blasco A, Mòdol-Caballero G. et al. Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system. Aging 2021; 13(14): 18051-93.
[http://dx.doi.org/10.18632/aging.203336] [PMID: 34319911]
[77]
Bisson JF, Nejdi A, Rozan P, Hidalgo S, Lalonde R, Messaoudi M. Effects of long-term administration of a cocoa polyphenolic extract (acticoa powder) on cognitive performances in aged rats. Br J Nutr 2008; 100(1): 94-101.
[http://dx.doi.org/10.1017/S0007114507886375] [PMID: 18179729]
[78]
Rendeiro C, Vauzour D, Rattray M. et al. Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor. PLoS One 2013; 8(5), e63535.
[http://dx.doi.org/10.1371/journal.pone.0063535] [PMID: 23723987]
[79]
Madhavadas S, Kapgal VK, Kutty BM, Subramanian S. The neuroprotective effect of dark chocolate in monosodium glutamate-induced nontransgenic Alzheimer disease model rats: Biochemical, behavioral, and histological studies. J Diet Suppl 2016; 13(4): 449-60.
[http://dx.doi.org/10.3109/19390211.2015.1108946] [PMID: 26673833]
[80]
Sebastiani G, Almeida-Toledano L, Serra-Delgado M. et al. Therapeutic effects of catechins in less common neurological and neurodegenerative disorders. Nutrients 2021; 13(7): 2232.
[http://dx.doi.org/10.3390/nu13072232] [PMID: 34209677]
[81]
Joseph JA, Shukitt-Hale B, Casadesus G, Fisher D. Oxidative stress and inflammation in brain aging: Nutritional considerations. Neurochem Res 2005; 30(6-7): 927-35.
[http://dx.doi.org/10.1007/s11064-005-6967-4] [PMID: 16187227]
[82]
Kaur R, Sood A, Lang DK. et al. Potential of flavonoids as anti-Alzheimer’s agents: Bench to bedside. Environ Sci Pollut Res Int 2022; 29(18): 26063-77.
[http://dx.doi.org/10.1007/s11356-021-18165-z] [PMID: 35067880]
[83]
Hsiao K, Chapman P, Nilsen S. et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996; 274(5284): 99-102.
[http://dx.doi.org/10.1126/science.274.5284.99] [PMID: 8810256]
[84]
Fernández-Fernández L, Comes G, Bolea I. et al. LMN diet, rich in polyphenols and polyunsaturated fatty acids, improves mouse cognitive decline associated with aging and Alzheimer’s disease. Behav Brain Res 2012; 228(2): 261-71.
[http://dx.doi.org/10.1016/j.bbr.2011.11.014] [PMID: 22119712]
[85]
Fernández-Fernández L, Esteban G, Giralt M. et al. Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids. Food Funct 2015; 6(4): 1251-60.
[http://dx.doi.org/10.1039/C5FO00052A] [PMID: 25756794]
[86]
Yoo H, Kim HS. Cacao powder supplementation attenuates oxidative stress, cholinergic impairment, and apoptosis in D-galactose-induced aging rat brain. Sci Rep 2021; 11(1): 17914.
[http://dx.doi.org/10.1038/s41598-021-96800-y] [PMID: 34504131]
[87]
Wang J, Varghese M, Ono K. et al. Cocoa extracts reduce oligomerization of amyloid-β: Implications for cognitive improvement in Alzheimer’s disease. J Alzheimers Dis 2014; 41(2): 643-50.
[http://dx.doi.org/10.3233/JAD-132231] [PMID: 24957018]
[88]
Cimini A, Gentile R, D’Angelo B. et al. Cocoa powder triggers neuroprotective and preventive effects in a human Alzheimer’s disease model by modulating BDNF signaling pathway. J Cell Biochem 2013; 114(10): 2209-20.
[http://dx.doi.org/10.1002/jcb.24548] [PMID: 23554028]
[89]
Navarrete-Yañez V, Garate-Carrillo A, Rodriguez A. et al. Effects of (-)-epicatechin on neuroinflammation and hyperphosphorylation of tau in the hippocampus of aged mice. Food Funct 2020; 11(12): 10351-61.
[http://dx.doi.org/10.1039/D0FO02438D] [PMID: 33201160]
[90]
Ayaz M, Sadiq A, Junaid M. et al. Flavonoids as prospective neuroprotectants and their therapeutic propensity in aging associated neurological disorders. Front Aging Neurosci 2019; 11: 155.
[http://dx.doi.org/10.3389/fnagi.2019.00155] [PMID: 31293414]
[91]
Williams RJ, Spencer JP. Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease. Free Radic Biol Med 2012; 52(1): 35-45.
[http://dx.doi.org/10.1016/j.freeradbiomed.2011.09.010] [PMID: 21982844]
[92]
Hamsalakshmi, Alex AM, Arehally Marappa M, Joghee S, Chidambaram SB. Therapeutic benefits of flavonoids against neuroinflammation: A systematic review. Inflammopharmacology 2022; 30(1): 111-36.
[http://dx.doi.org/10.1007/s10787-021-00895-8] [PMID: 35031904]
[93]
Molino S, Dossena M, Buonocore D. et al. Polyphenols in dementia: From molecular basis to clinical trials. Life Sci 2016; 161: 69-77.
[http://dx.doi.org/10.1016/j.lfs.2016.07.021] [PMID: 27493077]
[94]
Schaffer S, Asseburg H, Kuntz S, Muller WE, Eckert GP. Effects of polyphenols on brain ageing and Alzheimer’s disease: Focus on mitochondria. Mol Neurobiol 2012; 46(1): 161-78.
[http://dx.doi.org/10.1007/s12035-012-8282-9] [PMID: 22706880]
[95]
Spencer JP, Vauzour D, Rendeiro C. Flavonoids and cognition: The molecular mechanisms underlying their behavioural effects. Arch Biochem Biophys 2009; 492(1-2): 1-9.
[http://dx.doi.org/10.1016/j.abb.2009.10.003] [PMID: 19822127]
[96]
Vauzour D, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, Spencer JP. The neuroprotective potential of flavonoids: A multiplicity of effects. Genes Nutr 2008; 3(3-4): 115-26.
[http://dx.doi.org/10.1007/s12263-008-0091-4] [PMID: 18937002]
[97]
Caruana M, Vassallo N. Tea polyphenols in Parkinson’s disease. Adv Exp Med Biol 2015; 863: 117-37.
[http://dx.doi.org/10.1007/978-3-319-18365-7_6] [PMID: 26092629]
[98]
Jung UJ, Kim SR. Beneficial effects of flavonoids against Parkinson’s disease. J Med Food 2018; 21(5): 421-32.
[http://dx.doi.org/10.1089/jmf.2017.4078] [PMID: 29412767]
[99]
Jurado-Coronel JC, Ávila-Rodriguez M, Echeverria V. et al. Implication of green tea as a possible therapeutic approach for Parkinson disease. CNS Neurol Disord Drug Targets 2016; 15(3): 292-300.
[http://dx.doi.org/10.2174/1871527315666160202125519] [PMID: 26831259]
[100]
Renaud J, Nabavi SF, Daglia M, Nabavi SM, Martinoli MG. Epigallocatechin-3-gallate, a promising molecule for Parkinson’s disease? Rejuvenation Res 2015; 18(3): 257-69.
[http://dx.doi.org/10.1089/rej.2014.1639] [PMID: 25625827]
[101]
Wolz M, Kaminsky A, Löhle M, Koch R, Storch A, Reichmann H. Chocolate consumption is increased in Parkinson’s disease. Results from a self-questionnaire study. J Neurol 2009; 256(3): 488-92.
[http://dx.doi.org/10.1007/s00415-009-0118-9] [PMID: 19277767]
[102]
Hughes RN. The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory. Neurosci Biobehav Rev 2004; 28(5): 497-505.
[http://dx.doi.org/10.1016/j.neubiorev.2004.06.006] [PMID: 15465137]
[103]
Lalonde R. The neurobiological basis of spontaneous alternation. Neurosci Biobehav Rev 2002; 26(1): 91-104.
[http://dx.doi.org/10.1016/S0149-7634(01)00041-0] [PMID: 11835987]
[104]
Ali AA, Kamal MM, Khalil MG. et al. Behavioral, biochemical and histopathological effects of standardised pomegranate extract with vinpocetine, propolis or cocoa in a rat model of Parkinson’s disease. Exp Aging Res 2022; 48(2): 191-210.
[http://dx.doi.org/10.1080/0361073X.2021.1959823] [PMID: 34384037]
[105]
Datla KP, Zbarsky V, Rai D. et al. Short-term supplementation with plant extracts rich in flavonoids protect nigrostriatal dopaminergic neurons in a rat model of Parkinson’s disease. J Am Coll Nutr 2007; 26(4): 341-9.
[http://dx.doi.org/10.1080/07315724.2007.10719621] [PMID: 17906186]
[106]
Teixeira MD, Souza CM, Menezes AP. et al. Catechin attenuates behavioral neurotoxicity induced by 6-OHDA in rats. Pharmacol Biochem Behav 2013; 110: 1-7.
[http://dx.doi.org/10.1016/j.pbb.2013.05.012] [PMID: 23714698]
[107]
Rubio-Osornio M, Gorostieta-Salas E, Montes S. et al. Epicatechin reduces striatal MPP+-induced damage in rats through slight increases in SOD-Cu, Zn activity. Oxid Med Cell Longev 2015; 2015, 276039.
[http://dx.doi.org/10.1155/2015/276039] [PMID: 26301040]
[108]
Chidambaram SB, Bhat A, Ray B. et al. Cocoa beans improve mitochondrial biogenesis via PPARγ/PGC1α dependent signalling pathway in MPP+ intoxicated human neuroblastoma cells (SHSY5Y). Nutr Neurosci 2020; 23(6): 471-80.
[http://dx.doi.org/10.1080/1028415X.2018.1521088] [PMID: 30207204]
[109]
Xu Q, Langley M, Kanthasamy AG, Reddy MB. Epigallocatechin gallate has a neurorescue effect in a mouse model of Parkinson disease. J Nutr 2017; 147(10): 1926-31.
[http://dx.doi.org/10.3945/jn.117.255034] [PMID: 28835392]
[110]
Choi JY, Park CS, Kim DJ. et al. Prevention of nitric oxide-mediated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s disease in mice by tea phenolic epigallocatechin 3-gallate. Neurotoxicology 2002; 23(3): 367-74.
[http://dx.doi.org/10.1016/S0161-813X(02)00079-7] [PMID: 12387363]
[111]
Levites Y, Weinreb O, Maor G, Youdim MB, Mandel S. Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration. J Neurochem 2001; 78(5): 1073-82.
[http://dx.doi.org/10.1046/j.1471-4159.2001.00490.x] [PMID: 11553681]
[112]
Zhou T, Zhu M, Liang Z. (-)-Epigallocatechin-3-gallate modulates peripheral immunity in the MPTP-induced mouse model of Parkinson’s disease. Mol Med Rep 2018; 17(4): 4883-8.
[http://dx.doi.org/10.3892/mmr.2018.8470] [PMID: 29363729]
[113]
Xu Y, Zhang Y, Quan Z. et al. Epigallocatechin gallate (EGCG) inhibits alpha-synuclein aggregation: A potential agent for Parkinson’s disease. Neurochem Res 2016; 41(10): 2788-96.
[http://dx.doi.org/10.1007/s11064-016-1995-9] [PMID: 27364962]
[114]
Tseng HC, Wang MH, Chang KC. et al. Protective effect of (-)epigallocatechin-3-gallate on rotenone-induced Parkinsonism-like symptoms in rats. Neurotox Res 2020; 37(3): 669-82.
[http://dx.doi.org/10.1007/s12640-019-00143-6] [PMID: 31811588]
[115]
Anandhan A, Essa MM, Manivasagam T. Therapeutic attenuation of neuroinflammation and apoptosis by black tea theaflavin in chronic MPTP/probenecid model of Parkinson’s disease. Neurotox Res 2013; 23(2): 166-73.
[http://dx.doi.org/10.1007/s12640-012-9332-9] [PMID: 22669749]
[116]
Chen M, Wang T, Yue F. et al. Tea polyphenols alleviate motor impairments, dopaminergic neuronal injury, and cerebral α-synuclein aggregation in MPTP-intoxicated parkinsonian monkeys. Neuroscience 2015; 286: 383-92.
[http://dx.doi.org/10.1016/j.neuroscience.2014.12.003] [PMID: 25498223]
[117]
Onaolapo OJ, Odeniyi AO, Jonathan SO. et al. An investigation of the anti-parkinsonism potential of co-enzyme Q10 and co-enzyme Q10/levodopa-carbidopa combination in mice. Curr Aging Sci 2021; 14(1): 62-75.
[http://dx.doi.org/10.2174/1874609812666191023153724] [PMID: 31702498]
[118]
Stringer TP, Guerrieri D, Vivar C, van Praag H. Plant-derived flavanol (-)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice. Transl Psychiatry 2015; 5(1), e493.
[http://dx.doi.org/10.1038/tp.2014.135] [PMID: 25562843]
[119]
Messaoudi M, Bisson JF, Nejdi A, Rozan P, Javelot H. Antidepressant-like effects of a cocoa polyphenolic extract in Wistar-Unilever rats. Nutr Neurosci 2008; 11(6): 269-76.
[http://dx.doi.org/10.1179/147683008X344165] [PMID: 19000380]
[120]
Ito M, Kudo N, Miyake Y. et al. Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice. Exp Gerontol 2017; 98: 120-3.
[http://dx.doi.org/10.1016/j.exger.2017.07.010] [PMID: 28807824]
[121]
Rozan P, Hidalgo S, Nejdi A, Bisson JF, Lalonde R, Messaoudi M. Preventive antioxidant effects of cocoa polyphenolic extract on free radical production and cognitive performances after heat exposure in wistar rats. J Food Sci 2007; 72(3): S203-6.
[http://dx.doi.org/10.1111/j.1750-3841.2007.00297.x] [PMID: 17995815]
[122]
van Praag H, Lucero MJ, Yeo GW. et al. Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice. J Neurosci 2007; 27(22): 5869-78.
[http://dx.doi.org/10.1523/JNEUROSCI.0914-07.2007] [PMID: 17537957]
[123]
Rendeiro C, Spencer JP, Vauzour D, Butler LT, Ellis JA, Williams CM. The impact of flavonoids on spatial memory in rodents: From behaviour to underlying hippocampal mechanisms. Genes Nutr 2009; 4(4): 251-70.
[http://dx.doi.org/10.1007/s12263-009-0137-2] [PMID: 19727888]
[124]
Fruson L, Dalesman S, Lukowiak K. A flavonol present in cocoa (-)epicatechin] enhances snail memory. J Exp Biol 2012; 215(Pt 20): 3566-76.
[http://dx.doi.org/10.1242/jeb.070300] [PMID: 23014569]
[125]
Knezevic B, Komatsuzaki Y, de Freitas E, Lukowiak K. A flavanoid component of chocolate quickly reverses an imposed memory deficit. J Exp Biol 2016; 219(Pt 6): : 816-823.
[http://dx.doi.org/10.1242/jeb.130765] [PMID: 26823103]

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