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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Review Article

Synthetic Strategies for Quinoline Based Derivatives as Potential Bioactive Heterocycles

Author(s): Shivangi Sharma, Kuldeep Singh and Shivendra Singh*

Volume 20, Issue 6, 2023

Published on: 29 December, 2022

Page: [606 - 629] Pages: 24

DOI: 10.2174/1570179420666221004143910

Price: $65


Quinoline derivatives are an important class of heterocyclic compounds and possess various applications in synthetic organic chemistry, medicinal chemistry, material chemistry and natural product chemistry. This review article describes the different quinoline derivatives having antimalarial, analgesic, anti-inflammatory, antineoplastic, antibacterial, antifungal, antiviral, anthelmintic, antiprotozoal, cardiovascular, CNS and other useful bioactivities. We have delineated the general synthetic routes for the synthesis of many bioactive quinoline based heterocycles. In addition to this, we have also discussed the crucial synthetic routes as well as their mechanistic paths for the formation of bioactive quinoline derivatives. The study shows that substitution at the 4 and 8- position of quinoline is more crucial for bioactivity as compared to other positions.

Keywords: Quinoline, heterocycles, bioactive, synthesis, antimalarial quinoline, antimalarial.

Graphical Abstract
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