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Current Pediatric Reviews


ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

Review Article

Chronic Non-Bacterial Osteomyelitis (CNO) In Childhood: A Review

In Press, (this is not the final "Version of Record"). Available online 27 December, 2022
Author(s): Fiona Price-Kuehne and Kate Armon*
Published on: 27 December, 2022

DOI: 10.2174/1573396319666221027123723

Price: $95


Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory bone disorder mostly affecting children and adolescents. Although it is considered a rare disease, CNO is likely to be the single most common autoinflammatory bone disease in childhood, underdiagnosed and underre-ported due to a lack of awareness of the condition in both medics and patients and the absence of validated diagnostic criteria. The exact underlying pathogenesis of CNO remains unknown, making targeted treatment difficult. This issue is exacerbated by the lack of any randomised control trials, meaning that treatment strategies are based solely on retrospective reviews and case series. This review summarises the current concepts in pathophysiology, the clinical features that help dif-ferentiate important differential diagnoses, and an approach to investigating and managing children with CNO. Ultimately, the timely and thorough investigation of children and young people with CNO is vitally important to exclude important mimics and initiate appropriate management that can prevent the complications of persistent inflammatory bone disease.

Keywords: Autoinflammatory bone disorder, chronic nonbacterial osteomyelitis, chronic recurrent multifocal osteomyelitis, clinical features, current concepts in pathophysiology, investigation and management.

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