Login Register Cart 0
Generic placeholder image

Current Pediatric Reviews

Editor-in-Chief

ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Amino Acids Profile in Children with Acute Brucellosis

Author(s): Ahmet Guzelcicek, Nihayet Bayraktar and Mehmet Bayraktar*

Volume 20, Issue 2, 2024

Published on: 28 December, 2022

Page: [188 - 193] Pages: 6

DOI: 10.2174/1573396319666221114093653

Price: $65

Abstract

Background: Many new cases of brucella infections are seen in Turkey every year, especially in March, April, and May, due to the consumption of local unpasteurized cheese. Amino acids profiles have not been studied in brucellosis so far.

Aims: The amino acid profiles may be affected by infectious diseases. Our study aims to evaluate the plasma amino acid profile in the progression of acute brucellosis.

Methods: Plasma amino acid profile was performed by an 8045 LC-MS / MS device (Shimadzu 8045, Japan) using JASEM amino acid kit.

Results: Analysis of 45 amino acid profiles was made and results profiles showed significant differences in concentrations and types of amino acids in brucella patients. We observed a significant difference in terms of alanine, arginine, aspartic acid, glutamine, glutamic acid, glycine, isoleucine, ornithine, phenylalanine, proline, tyrosine, valine, alpha-aminoadipic acid, alpha-amino-pimelic acid, argininosuccinic acid, gamma-aminobutyric acid, thiaproline, 1-methylhistidine, 3-methylhistidine, hydroxylysine, hydroxyproline, cystine, serotonin, ethanolamine, and taurine (p-value < 0.05 for each). No significant differences were determined regarding asparagine, citrulline, histidine, leucine, alloisoleucine, lysine, methionine, serine, threonine, tryptophan, anserine, alpha aminobutyric acid, beta aminoisobutyric acid, beta-alanine, cystathionine, histamine, and 5-oh-trp (p-value > 0.05 for all).

Conclusion: Patients with brucellosis have a specific profile of amino acids which may reflect sequelae of pathological and metabolic biochemical changes in the disease process due to the growth of Brucella spp. in the human body leading to an imbalance of amino acid levels.

Keywords: Amino acids profiles, acute brucellosis, pediatrics population, JASEM amino acid kit, LC-MS device, unpasteurized cheese.

« Previous Next »
[1]
Dadar M, Shahali Y, Wareth G. Molecular diagnosis of acute and chronic brucellosis in humans. In: Microbial Technology for the Welfare of Society. Germany: Springer 2019; pp. 223-45.
[2]
Díaz R, Moriyón I. Laboratory techniques in the diagnosis of human brucellosis. In: Brucellosis: Clinical and Laboratory Aspects. Florida, USA: CRC Press 2020; pp. 73-83.
[http://dx.doi.org/10.1201/9781003068518-8]
[3]
Saddique A, Ali S, Akhter S, et al. Acute febrile illness caused by Brucella abortus infection in humans in Pakistan. Int J Environ Res Public Health 2019; 16(21): 4071.
[http://dx.doi.org/10.3390/ijerph16214071] [PMID: 31652718]
[4]
Djangwani J, Ooko Abong’ G, Gicuku Njue L, Kaindi DWM. Brucellosis: Prevalence with reference to East African community countries – A rapid review. Vet Med Sci 2021; 7(3): 851-67.
[http://dx.doi.org/10.1002/vms3.425] [PMID: 33421354]
[5]
Mol JPS, Guedes ACB, Eckstein C, et al. Diagnosis of canine brucellosis: Comparison of various serologic tests and PCR. J Vet Diagn Invest 2020; 32(1): 77-86.
[http://dx.doi.org/10.1177/1040638719891083] [PMID: 31752635]
[6]
Ren J, Peng Q. A brief review of diagnosis of small ruminants brucellosis. Curr Med Chem 2021; 28-4576(22): 4569-76.
[http://dx.doi.org/10.2174/0929867328666201231121226]
[7]
Tian M, Song M, Yin Y, et al. Characterization of the main immunogenic proteins in Brucella infection for their application in diagnosis of brucellosis. Comp Immunol Microbiol Infect Dis 2020; 70: 101462.
[http://dx.doi.org/10.1016/j.cimid.2020.101462] [PMID: 32143107]
[8]
Yagupsky P, Morata P, Colmenero JD. Laboratory diagnosis of human brucellosis. Clin Microbiol Rev 2019; 33(1): e00073-19.
[http://dx.doi.org/10.1128/CMR.00073-19]
[9]
Nie C, He T, Zhang W, Zhang G, Ma X. Branched chain amino acids: Beyond nutrition metabolism. Int J Mol Sci 2018; 19(4): 954.
[http://dx.doi.org/10.3390/ijms19040954] [PMID: 29570613]
[10]
Stabler SP. Alterations in sulfur amino acids as biomarkers of disease. J Nutr 2020; 150 (Suppl. 1): 2532S-7S.
[http://dx.doi.org/10.1093/jn/nxaa118] [PMID: 33000156]
[11]
Dean AS, Crump L, Greter H, Hattendorf J, Schelling E, Zinsstag J. Clinical manifestations of human brucellosis: A systematic review and meta-analysis. PLoS Negl Trop Dis 2012; 6(12): e1929.
[http://dx.doi.org/10.1371/journal.pntd.0001929] [PMID: 23236528]
[12]
Adetunji SA, Ramirez G, Foster MJ, Arenas-Gamboa AM. A systematic review and meta-analysis of the prevalence of osteoarticular brucellosis. PLoS Negl Trop Dis 2019; 13(1): e0007112.
[http://dx.doi.org/10.1371/journal.pntd.0007112] [PMID: 30657765]
[13]
Artuk C. GUL H. Complications and treatment of brucellosis: 11-year results. Acta Med Mediter 2019; 35: 1131.
[http://dx.doi.org/10.19193/0393-6384_2019_3_201]
[14]
Sen P, Demirdal T, Nemli SA. Predictive value of inflammation markers in brucellosis. Arch Iran Med 2019; 22(11): 640-5.
[PMID: 31823629]
[15]
Zheng R, Xie S, Lu X, et al. A systematic review and meta-analysis of epidemiology and clinical manifestations of human brucellosis in China. BioMed Res Int 2018; 2018: 5712920.
[http://dx.doi.org/10.1155/2018/5712920] [PMID: 29850535]
[16]
Figura M. Kuśmierska K, Bucior E, et al. Serum amino acid profile in patients with Parkinson’s disease. PLoS One 2018; 13(1): e0191670.
[http://dx.doi.org/10.1371/journal.pone.0191670] [PMID: 29377959]
[17]
Rahimi N, Razi F, Nasli-Esfahani E, Qorbani M, Shirzad N, Larijani B. Amino acid profiling in the gestational diabetes mellitus. J Diabetes Metab Disord 2017; 16(1): 13.
[http://dx.doi.org/10.1186/s40200-016-0283-1] [PMID: 28367428]
[18]
Wang L, Liu S, Yang W, et al. Plasma amino acid profile in patients with aortic dissection. Sci Rep 2017; 7(1): 40146.
[http://dx.doi.org/10.1038/srep40146] [PMID: 28071727]
[19]
Ablin J, Mevorach D, Eliakim R. Brucellosis and the gastrointestinal tract. The odd couple. J Clin Gastroenterol 1997; 24(1): 25-9.
[http://dx.doi.org/10.1097/00004836-199701000-00005] [PMID: 9013346]
[20]
Aziz S, Al-Anazi A, Al-Aska A. A review of gastrointestinal manifestations of Brucellosis. Saudi J Gastroenterol 2005; 11(1): 20-7.
[http://dx.doi.org/10.4103/1319-3767.33333] [PMID: 19861843]
[21]
Ahlman B, Ljungqvist O, Persson B, Bindslev L, Wernerman J. Intestinal amino acid content in critically ill patients. JPEN J Parenter Enteral Nutr 1995; 19(4): 272-8.
[http://dx.doi.org/10.1177/0148607195019004272] [PMID: 8523625]
[22]
Woo HI, Chun MR, Yang JS, et al. Plasma amino acid profiling in major depressive disorder treated with selective serotonin reuptake inhibitors. CNS Neurosci Ther 2015; 21(5): 417-24.
[http://dx.doi.org/10.1111/cns.12372] [PMID: 25611566]
[23]
Dileep-Satya K, Attri SV, Sharawat IK, et al. Plasma and urinary amino acid profile in children with infantile tremor syndrome. J Trop Pediatr 2021; 67(3): fmab063.
[http://dx.doi.org/10.1093/tropej/fmab063]
[24]
Tinkov AA, Skalnaya MG, Skalny AV. Serum trace element and amino acid profile in children with cerebral palsy. J Trace Elem Med Biol 2021; 64: 126685.
[http://dx.doi.org/10.1016/j.jtemb.2020.126685] [PMID: 33249374]
[25]
Reinehr T, Wolters B, Knop C, et al. Changes in the serum metabolite profile in obese children with weight loss. Eur J Nutr 2015; 54(2): 173-81.
[http://dx.doi.org/10.1007/s00394-014-0698-8] [PMID: 24740590]

Rights & Permissions Print Cite
Article Metrics
16
3
International Nurses Day
© 2024 Bentham Science Publishers | Privacy Policy