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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Research Article

Ginsenoside Rb1 Suppresses AOM/DSS-induced Colon Carcinogenesis

Author(s): Ling Wang, Qing-Qing Zhang, Yu-Yu Xu, Rui Zhang, Qing Zhao, Yu-Qing Zhang, Xue-Hong Huang, Bin Jiang* and Min Ni*

Volume 23, Issue 9, 2023

Published on: 20 February, 2023

Page: [1067 - 1073] Pages: 7

DOI: 10.2174/1871520623666230119092735

Price: $65


Background: Colorectal cancer (CRC) is the third most common cancer worldwide. Current treatments, including surgery, radiotherapy, and chemotherapy, are limited by severe side effects and the development of resistance.

Objective: Therefore, it is important to find additional therapies to combat the problem. Ginsenoside Rb1 is the main active ingredient of ginseng, which is a well-known herb in traditional Chinese medicine. Ginsenoside is reported to play an important role in the prevention and treatment of cancer.

Methods: We established Azoxymethane (AOM)/Dextran sodium sulfate (DSS) colon cancer model based on inflammation, observed the beneficial effect of ginsenoside Rb1, and detected the changes in gut microbiota.

Results: Our experimental results showed that ginsenoside Rb1 significantly reduced the levels of TNF-α, IL-6, IL- 17A, IL-33, IL-1β, and IL-22, increased the level of IL-10, and also changed the gut microbiota composition. These results suggested that ginsenoside Rb1 can be used to prevent inflammation-associated CRC development and may provide an effective therapeutic strategy for CRC by relieving chronic inflammation and restoring the gut microenvironment in the AOM/DSS-induced model of colitis-associated colorectal cancer in mice.

Conclusion: Ginsenoside Rb1 significantly attenuated AOM/DSS-induced colon carcinogenesis.

Keywords: Colorectal cancer, ginsenoside Rb1, inflammation, gut microenvironment, colitis, carcinogenesis.

Graphical Abstract
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