Generic placeholder image

Current Drug Delivery


ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

Pineal Hormone Melatonin: Solubilization Studies in Model Aqueous Gastrointestinal Environments

Author(s): Marilena Vlachou, Aphrodite Eikosipentaki and Vassilios Xenogiorgis

Volume 3, Issue 3, 2006

Page: [255 - 265] Pages: 11

DOI: 10.2174/156720106777731073

Price: $65


In view of the variable oral absorption, short biological half-life and extensive first pass metabolism of the pineal hormone melatonin, an investigation of its solubilization profile in modified aqueous media is described. Four readily available surfactants were examined with respect to their ability to enhance the solubility of melatonin under simulated physiological conditions. The most effective surfactant was found to be the sodium salt of dioctyl sulfosuccinate (DSS), which augmented the aqueous solubility of the hormone by 23%. This is attributed to a favourable stereoelectronic interaction between DSS and the nucleus of melatonin, which seems to be independent of the pH of the dissolution medium. A noteworthy synergistic effect in the aqueous solubilization of the hormone occurs when a 1:2 DSS-sodium dodecyl sulphate mixture is used.

Keywords: Melatonin, Solubilization, Surfactants, Gastrointestinal pH

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy