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Current Cancer Drug Targets


ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Mini-Review Article

mRNA Vaccine - A New Cancer Treatment Strategy

Author(s): Tian Tan, Shu-Ting Deng, Bing-Huo Wu, Qi Yang, Meng-Wan Wu, Hong Wu, Chen-Hui Cao* and Chuan Xu*

Volume 23, Issue 9, 2023

Published on: 27 April, 2023

Page: [669 - 681] Pages: 13

DOI: 10.2174/1568009623666230222124424

Price: $65


The corresponding mRNA vaccines Comirnaty (BNT162b2) and Spikevax (mRNA-1273) have been authorized for emergency use since the COVID-19 outbreak. Most clinical researches have also discovered that the mRNA vaccine is a revolutionary strategy for preventing and treating numerous diseases, including cancers. Unlike viral vectors or DNA vaccines, mRNA vaccines cause the body to directly produce proteins following injection. Delivery vectors and mRNAs that encode tumor antigens or immunomodulatory molecules work together to trigger an anti-tumor response. Before mRNA vaccines may be employed in clinical trials, a number of challenges need to be resolved. These include establishing effective and safe delivery systems, generating successful mRNA vaccines against diverse types of cancers, and proposing improved combination therapy. Therefore, we need to improve vaccine-specific recognition and develop mRNA delivery mechanisms. This review summarizes the complete mRNA vaccines’ elemental composition and discusses recent research progress and future direction for mRNA tumor vaccines.

Keywords: mRNA vaccine, tumor antigen, cancer, clinical trials, delivery system, immunotherapy.

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