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Current HIV Research


ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Research Article

Point-of-Care HIV Test for a Promising Simple and Rapid Clinical HIV Definite Diagnosis Process

Author(s): Zhenrui Xue, Min Song, Ping Peng and Chunyan Yao*

Volume 21, Issue 2, 2023

Published on: 28 March, 2023

Page: [117 - 121] Pages: 5

DOI: 10.2174/1570162X21666230309115137

Price: $65


Background: This study compared and evaluated the performance of a commercially available HIV POC rapid test with assays commonly used in clinical laboratories, including enzymelinked immunosorbent assay (ELISA), western blot (WB), and reverse transcription-polymerase chain reaction (RT-PCR).

Methods: 500 patients’ samples were detected by the POC rapid test and clinically common tests (WB, ELISA, and RT-PCR) to compare detection performance, test time, and test cost.

Results: Taking the WB results as the gold standard, the results of RT-PCR were completely consistent with WB. The concordance of ELISA and POC with WB was 82.00% and 93.80%, respectively, with statistically significant differences (p<0.05).

Conclusion: This study provides evidence that rapid HIV POC assays are superior to ELISA and that WB and RT-PCR have equal detection performance in detecting HIV. As a result, a rapid and costeffective HIV definition process based on the POC assays can be proposed.

Keywords: HIV, point-of-care, concordance, detection time, cost-effective, definition process.

Graphical Abstract
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