Review Article

Potential Phytochemicals for Prevention of Familial Breast Cancer with BRCA Mutations

Author(s): Aliasgar Fakruddin Shahiwala* and Gazala Afreen Khan

Volume 24, Issue 6, 2023

Published on: 14 April, 2023

Page: [521 - 531] Pages: 11

DOI: 10.2174/1389450124666230314110800

Price: $65

Abstract

Breast cancer has remained a global challenge and the second leading cause of cancer mortality in women and family history. Hereditary factors are some of the major risk factors associated with breast cancer. Out of total breast cancer cases, 5-10% account only for familial breast cancer, and nearly 50% of all hereditary breast cancer are due to BRCA1/BRCA2 germline mutations. BRCA1/2 mutations play an important role not only in determining the clinical prognosis of breast cancer but also in the survival curves. Since this risk factor is known, a significant amount of the healthcare burden can be reduced by taking preventive measures among people with a known history of familial breast cancer. There is increasing evidence that phytochemicals of nutrients and supplements help in the prevention and cure of BRCA-related cancers by different mechanisms such as limiting DNA damage, altering estrogen metabolism, or upregulating expression of the normal BRCA allele, and ultimately enhancing DNA repair. This manuscript reviews different approaches used to identify potential phytochemicals to mitigate the risk of familial breast cancer with BRCA mutations. The findings of this review can be extended for the prevention and cure of any BRCAmutated cancer after proper experimental and clinical validation of the data.

Keywords: Phytochemicals, familial breast cancer, BRCA mutations, ATM inducers, PI3K/AKT/mTOR pathway inhibitors, microRNAs regulators, PARP inhibitors.

Graphical Abstract
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