Abstract
The current gold standard for imaging infection is radiolabeled white blood cells. For reasons of safety, simplicity and cost, it would be desirable to have a receptor-specific ligand that could be used for imaging infection and that would allow a differential diagnosis between sterile and septic inflammatory processes. Ligands tested for this purpose include labeled peptides ( Tc-labeled f-Met-Leu-Phe, I-IL-1ra, Tc-IL-8, Tc-P483H, Tc-P1827DS, Tc-C5ades- Arg, Tc-RP517, 111In-DPC11870-11), human polyclonal antibodies, monoclonal antibodies, antibody fragments, antimicrobial agents (ciprofloxacin, sparfloxacin, ceftizoxime, isoniazid, ethambutol, fluconazole, all labeled with 9 Tc), antimicrobial peptides and bacteriophages. Radiolabeled antibodies represent a valid alternative to labeled white blood cells under specific conditions and indications. Radiolabeled antibiotics and antimicrobial peptides are promising candidates for an infection-specific radiopharmaceutical. However, at present we still need to investigate many basic aspects to better understand the mechanisms of binding and accumulation of this class of radiopharmaceuticals to bacteria.
Current Pharmaceutical Design
Title: Receptor Binding Ligands to Image Infection
Volume: 14 Issue: 31
Author(s): M. Chianelli, O. C. Boerman, G. Malviya, F. Galli, W. J.G. Oyen and A. Signore
Affiliation:
Abstract: The current gold standard for imaging infection is radiolabeled white blood cells. For reasons of safety, simplicity and cost, it would be desirable to have a receptor-specific ligand that could be used for imaging infection and that would allow a differential diagnosis between sterile and septic inflammatory processes. Ligands tested for this purpose include labeled peptides ( Tc-labeled f-Met-Leu-Phe, I-IL-1ra, Tc-IL-8, Tc-P483H, Tc-P1827DS, Tc-C5ades- Arg, Tc-RP517, 111In-DPC11870-11), human polyclonal antibodies, monoclonal antibodies, antibody fragments, antimicrobial agents (ciprofloxacin, sparfloxacin, ceftizoxime, isoniazid, ethambutol, fluconazole, all labeled with 9 Tc), antimicrobial peptides and bacteriophages. Radiolabeled antibodies represent a valid alternative to labeled white blood cells under specific conditions and indications. Radiolabeled antibiotics and antimicrobial peptides are promising candidates for an infection-specific radiopharmaceutical. However, at present we still need to investigate many basic aspects to better understand the mechanisms of binding and accumulation of this class of radiopharmaceuticals to bacteria.
Export Options
About this article
Cite this article as:
Chianelli M., Boerman C. O., Malviya G., Galli F., Oyen J.G. W. and Signore A., Receptor Binding Ligands to Image Infection, Current Pharmaceutical Design 2008; 14 (31) . https://dx.doi.org/10.2174/138161208786549416
DOI https://dx.doi.org/10.2174/138161208786549416 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Dendrimers and Dendritic Polymers as Anti-infective Agents: New Antimicrobial Strategies for Therapeutic Drugs
Anti-Infective Agents in Medicinal Chemistry Human Immunodeficiency Virus (HIV) and Stroke: Targets for Intervention
Infectious Disorders - Drug Targets Infection, Infectious Agents and Vascular Disease
Reviews on Recent Clinical Trials Hyperglycemia, Hypoglycemia and Dementia: Role of Mitochondria and Uncoupling Proteins
Current Molecular Medicine Virtual Screening for the Development of New Effective Compounds Against Staphylococcus aureus
Current Medicinal Chemistry Severe Community-Acquired Pneumonia (CAP) due to Atypical Pathogens
Current Respiratory Medicine Reviews Chest Pain in Children
Current Pediatric Reviews Use of Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging in Drug Development for Ischemic Stroke
Current Drug Targets - CNS & Neurological Disorders Combating Vancomycin Resistance in Bacteria: Targeting the D-ala-D-ala Dipeptidase VanX
Infectious Disorders - Drug Targets The Role of 18FDG PET/CT in the Assessment of Endocarditis, Myocarditis and Pericarditis
Current Radiopharmaceuticals Inhibition of Quorum Sensing in Staphylococcus spp.
Current Pharmaceutical Design The Guanylyl Cyclase Inhibition by MB as Vasoplegic Circulatory Shock Therapeutical Target
Current Drug Targets Development and Validation of a UV-Spectrophotometric Method for Determination of Flucloxacillin Sodium in Capsules
Current Pharmaceutical Analysis Antithrombotic Therapy in Cardiac Embolism
Current Cardiology Reviews Insights into Airway Infections by Enterococci: A Review
Recent Patents on Anti-Infective Drug Discovery Ethanol and Inflammation
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Dealing with the Substance Abuse Epidemic and Infective Endocarditis:Clinical, Immunologic and Pathogenetic Aspects
Current Vascular Pharmacology Bacterial Proteases in Disease – Role in Intracellular Survival, Evasion of Coagulation/ Fibrinolysis Innate Defenses, Toxicoses and Viral Infections
Current Pharmaceutical Design Pneumonia Due to Methicilin-Resistant Staphylococcus aureus (MRSA): A Review
Current Respiratory Medicine Reviews Prevalence and Resistance Profiles of Vancomycin-resistant Enterococcal Isolates in Iran; An Eight-month Report from Nine Major Cities
Infectious Disorders - Drug Targets