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Current Cancer Drug Targets


ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Review Article

Overcoming the Limitations of Therapeutic Strategies to Combat Pancreatic Cancer using Nanotechnology

Author(s): Shivang Dhoundiyal and Md. Aftab Alam*

Volume 23, Issue 9, 2023

Published on: 28 April, 2023

Page: [697 - 717] Pages: 21

DOI: 10.2174/1568009623666230329085618

Price: $65


There is a significant unmet demand for the treatment of pancreatic cancer. Many patients do not make it to past five years after diagnosis. The effectiveness of treatment varies greatly from patient to patient, and many people are too weak to endure chemotherapy or surgery. Unfortunately, by the time patients receive the diagnosis, the tumour typically spreads, rendering these chemotherapies ineffective. Effective anticancer drugs can be better formulated with the help of nanotechnology, which can help them overcome issues with their physicochemical features, such as their poor water solubility or their short half-life in the bloodstream after administration. Many of the reported nanotechnologies offer multifunctional qualities including image guidance and controlled release, in addition to site-specific targeting to the site of action. In this review, we will examine the current status of the most promising nanotechnologies for treating pancreatic cancer, including those still in the research and development phase as well as those that have recently been given the green signal for use in clinical practice.

Keywords: Pancreatic cancer, tumour microenvironment, chemotherapy, radiotherapy, photodynamic therapy, immunotherapy, nanotechnology.

Graphical Abstract
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