Introduction: A new, ecological, and stability-indicating method by HPLC was developed for the quantification of moxifloxacin in tablets. A C18 column at 33°C, purified water acidified with 0.2% phosphoric acid and ethanol (74:26,v/v), flow rate at 1.0 mLmin-1, injection volume of 5 µL, and detection at 290 nm was used.
Method: The method was linear (2-12 µgmL-1), selective, accurate (100.86%), precise (RSD<2%), and robust.
Result: The retention time for moxifloxacin in tablets was approximately 4.4 minutes.
Conclusion: To sum up, a method based on the principles of green analytical chemistry was successfully developed and validated for the quantification of moxifloxacin in tablets.
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[http://dx.doi.org/10.1039/c1pp05259d] [PMID: 22186905]
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